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| Latest patents |
Results: 421-450 of 1119
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Substituted pyrimidinones bearing acidic functional groups as angiotensin II antagonists
OF THE INVENTION This invention relates to novel substituted fused pyrimidinone compounds which are useful as angiotensin II antagonists, primarily as antihypertensives. The compounds of this inventi... Read More
Inventors: Chakravarty, Prasun K.; Mantlo, Nathan B.; Greenlee, William J.; Patchett, Arthur A.; Kim, Dooseop;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Chemical compounds
What is claimed is: 1. A compound of the formula (1): ##STR10## or a pharmaceutically acceptable salt thereof, wherein X is O or S; R.sup.1 is C.sub.2-6 alkyl, C.sub.2-6 alkenyl, C.sub.3.5 cycloalkylC... Read More
Inventors: Coates, William J.; Flynn, Sean T.;, Assignee: Smith Kline & French Laboratories Ltd. (Welwyn Garden City, GB2) |
4-aminoquinazoline derivatives
OF THE INVENTION In the formula (I), the C1-4 alkyl group represented by R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.9, R.sup.10, R.sup.11, R.sup.12, R.sup.13, R.sup... Read More
Inventors: Lee, Sung J.; Konishi, Yoshitaka; Macina, Orest T.; Kondo, Kigen; Yu, Dingwei T.;, Assignee: Ono Pharmaceutical Co., Ltd. (Osaka, JP) |
Quinazoline compounds
We claim: 1. A compound or a pharmacologically acceptable salt thereof selected from the group consisting of: 4-(3-ethoxycarbonylpropyl)amino-6,7,8-trimethoxy-quinazoline; 4-(3-carboxypropyl)amino-6,7... Read More
Inventors: Takase, Yasutaka; Watanabe, Nobuhisa; Adachi, Hideyuki; Kodama, Kohtaro; Ishihara, Hiroki; Saeki, Takao; Souda, Shigeru;, Assignee: Eisai Co., Ltd. (JP) |
Hemoregulatory compounds
OF THE INVENTION The compounds of the invention are represented by structural Formula (I) ##STR1## wherein: R.sub.1 is independently NH.sub.2, OH, SH, CN, CO.sub.2 H or hydrogen; R.sub.2 is independe... Read More
Inventors: Bhatnagar, Pradip Kumar; Heerding, Dirk Andries;, Assignee: SmithKline Beecham Corporation (Philadelphia, PA) |
Indole derivatives as 5-HT receptor antagonist
I claim: 1. A compound of formula (I): ##STR9## wherein: R.sup.1 and R.sup.2 groups are each independently hydrogen, C.sub.1-6 alkyl optionally substituted by NR.sup.12 R.sup.13, C.sub.2-6 alkenyl, C.... Read More
Inventors: Bromidge, Steven Mark;, Assignee: SmithKline Beecham plc (Brentford, GB) |
Pyrazolopyrimidinone antianginal agents
OF THE INVENTION Depending on the nature of R.sup.4, the compounds of formula (I) may be prepared by a variety of methods from a compound of formula (II): ##STR3## wherein R.sup.1, R.sup.2 and R.sup.... Read More
Inventors: Bell, Andrew S.; Terrett, Nicholas K.;, Assignee: Pfizer Inc. (New York, NY) |
Quinazolinone antianginal agents
I claim: 1. A compound of the formula: ##STR12## or a pharmaceutically acceptable salt thereof, wherein R.sup.1 is H, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy or CONR.sup.5 R.sup.6 ; R.sup.2 is... Read More
Inventors: Terrett, Nicholas K.;, Assignee: Pfizer Inc. (New York, NY) |
6-heterocycyclyl pyrazolo[3,4-d]pyrimidin-4-ones and compositions and method of use thereof
INCLUSIVE OF PREFERRED EMBODIMENTS The compounds of Formula I may exist in tautomeric equilibrium with the corresponding enol form: ##STR10## While the compounds are believed to be predominantly in t... Read More
Inventors: Bacon, Edward R.; Singh, Baldev; Lesher, deceased, George Y.;, Assignee: Sterling Winthrop Inc. (Malvern, PA) |
6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof
INCLUSIVE OF PREFERRED EMBODIMENTS The compounds of Formula I may exist in tautomeric equilibrium with the corresponding enol form: ##STR15## While the compounds are believed to be predominately in t... Read More
Inventors: Bacon, Edward R.; Daurn, Sol J.; Singh, Baldev;, Assignee: Sanofi Winthrop, Inc. (New York, NY) |
6-aryl pyrazolo?3,4-D! pyrimidin-4-ones and compositions and method of use thereof
INCLUSIVE OF PREFERRED EMBODIMENTS The compounds of Formula I may exist in tautomeric equilibrium with the corresponding enol form: ##STR12## While the compounds are believed to be predominantly in t... Read More
Inventors: Bacon, Edward R.; Singh, Baldev;, Assignee: Sanofi (Paris, FR) |
3-phenyl-pyridine-derivatives
OF THE INVENTION The present invention relates to compounds of the general formula ##STR3## wherein R is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl; R.sup.1 is hydrogen or haloge... Read More
Inventors: Bos, Michael; Galley, Guido; Godel, Thierry; Hoffmann, Torsten; Hunkeler, Walter; Schnider, Patrick; Stadler, Heinz;, Assignee: Hoffmann-La Roche Inc. (Nutley, NJ) |
Anti-psychotic phthalimidine derivatives
We claim: 1. A compound of the formula ##STR27## and pharmaceutically acceptable acid-addition salts thereof, in which formula R.sub.0 and R.sub.1 are the same or different and are each selected from ... Read More
Inventors: Bengtsson, Karl S.; Thorberg, Seth O.; Ogren, Sven O.;, Assignee: Astra Lakemedel Aktiebolag (Sodertalje, SE) |
Piperid-4-yl ureas and thio ureas used as antidepressant agents
We claim: 1. A compound of the formula ##STR22## wherein n is 0 or 1; R.sup.1, R.sup.2, R.sup.3 and R.sup.9 are, independently, hydrogen or a lower alkyl group; X is .dbd.O or .dbd.S, Y is --O-- or a ... Read More
Inventors: Archibald, John L.; Ward, Terence J.;, Assignee: |
3-indolecarboxamides for control of circulatory diseases
OF THE INVENTION The 3-indolecarboxamide compounds of the present invention are represented by the following formula: ##STR2## wherein R.sup.1 is a hydrogen atom or a C.sub.1-4 alkyl group; each of R... Read More
Inventors: Tahara, Tetsuya; Ikebe, Tsuguo; Maruyama, Yutaka; Yaoka, Osamu; Miura, Yohji;, Assignee: Yoshitomi Pharmaceutical Industries, Ltd. (Osaka, JP) |
Diarylalkyl-substituted alkylamines and medicaments containing them
We claim: 1. A compound of the formula I ##STR168## in which: R.sup.1 is (C.sub.3 -C.sub.8)-cycloalkyl, straight-chain or branched (C.sub.2 -C.sub.6)-alkenyl, (C.sub.5 -C.sub.8)-cycloalkenyl, or is ##... Read More
Inventors: Ruger, Wolfgang; Urbach, Hansjorg; Bartmann, Wilhelm; Kaiser, Joachim;, Assignee: Hoechst Aktiengesellschaft (DE) |
N-benzylpiperidine amides
OF THE INVENTION The term "benzodioxole" is defined to mean the substituent of the formula ##STR2## As used herein, the expression "alkoxy" is defined to include alkyl of one to ten carbon atoms. The... Read More
Inventors: Desai, Bipinchandra N.; Fowler, Kerry W.;, Assignee: G. D. Searle & Co. (Chicago, IL) |
Substituted N-benzylpiperidine amides
OF THE INVENTION As used herein, the term "alkyl" shall mean straight or branched chain carbon-carbon linkages of from one to ten carbon atoms. "Alkenyl" shall have the same meaning, except that one ... Read More
Inventors: Desai, Bipinchandra N.; Fowler, Kerry W.; Moormann, Alan E.;, Assignee: G. D. Searle & Co. (Chicago, IL) |
5-isoquinolinesulfonamides
We claim: 1. A compound selected from those of formula (I): ##STR18## in which: n is 0 or 1 to 4 inclusive, m and p are 1 to 4 inclusive, it being understood that the sum m+p is 2, 3, 4 or 5, r is 1 t... Read More
Inventors: Peglion, Jean-Louis; Vilaine, Jean-Paul; Villeneuve, Nicole; Janiak, Philip;, Assignee: Adir et Compagnie (Courbevoie, FR) |
Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents
OF THE INVENTION The novel compounds of this invention have structural formula: ##STR3## or a pharmaceutically acceptable salt thereof, wherein: Ar is an aromatic ring selected from; 1) benzo, 2) thi... Read More
Inventors: Baldwin, John J.; Claremon, David A.; Elliott, Jason M.; Ponticello, Gerald S.; Remy, David C.; Selnick, Harold G.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Ameliorant for blood lipid metabolism
We claim: 1. A method for ameliorating blood lipid metabolism in a mammal with a blood lipid metabolism disorder, which comprises administering to said mammal a therapeutically, effective amount of a ... Read More
Inventors: Masuda, Yoshinobu; Minato, Hisao; Ikeno, Akihisa; Takeyama, Kunihiko; Hosoki, Kanoo;, Assignee: Dainippon Pharmaceutical Co., Ltd. (Osaka, JP) |
Orally-active nipecotamide glycolamide esters for the treatment of thrombosis disorders
OF THE INVENTION More particularly, the present invention is directed to compounds of the following formula (I): ##STR3## wherein M is (CH.sub.2).sub.m, CH.dbd.CH or C.tbd.C; A is selected from any o... Read More
Inventors: Hoekstra, William J.;, Assignee: Ortho-McNeil Pharmaceutical, Inc. (Raritan, NJ) |
1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
OF THE INVENTION This invention relates to novel compounds of the Formula I: ##STR9## and their enantiomeric, diastereomeric, pharmaceutically acceptable salt or prodrug forms thereof wherein: R.sup.... Read More
Inventors: Jin, Fuqiang; Confalone, Pasquale Nicholas;, Assignee: The DuPont Merck Pharmaceutical Company (Wilmington, DE) |
Novel drug permeable wall
A primary object of this invention is to provide means and methods for modifying the permeability of a drugpermeable polymeric wall adapted to release a drug at a controlled rate from a drug-containin... Read More
Inventors: Leeper, Harold M.; Michaels, Alan S.;, Assignee: Alza Corporation (Palo Alto, CA) |
Substituted amino-hydrazinopyridazines
What is claimed is: 1. A compound of the formula: ##SPC32## where each X is the same and represents halo of atomic weight between about 35 to 80, and R.sub.1 represents lower alkenyl, --(CH.sub.2).sub... Read More
Inventors: Anderson, Paul L.; Houlihan, William J.; Manning, Robert E.;, Assignee: Sandoz, Inc. (E. Hanover, NJ) |
Substituted 2-aminomethylphenyl sulfamates
What is claimed is: 1. A compound of the formula: ##STR5## wherein R is hydrogen, straight or branched chain lower alkyl of 1-5 carbon atoms, aralkyl up to 8 carbon atoms or phenyl; R.sup.1 is hydroge... Read More
Inventors: Smith, Robert L.; Stokker, Gerald E.; Cragoe, Jr., Edward J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Hydrogel and production thereof
The following is claimed: 1. A hydrogel comprising a water-soluble polymer selected from the group consisting of dextrans, starches and celluloses containing a chelating agent selected from the group ... Read More
Inventors: Shimizu, Hirohiko; Ozawa, Hitoshi;, Assignee: Toray Industries, Inc. (Tokyo, JA) |
Enteral contrast medium useful for nuclear magnetic resonance imaging and its preparation
What is claimed is: 1. An enterally administrable aqueous contrast medium useful for proton NMR imaging of a body cavity, comprising an amount of a physiologically compatible, paramagnetic compound ef... Read More
Inventors: Weinmann, Hanns-Joachim; Gries, Heinz; Michel, Heinrich;, Assignee: Schering Aktiengesellschaft (Berlin and Berkgamen, DE) |
Mixed complexes as shift and contrast reagents in NMR imaging and spectroscopy
OF THE INVENTION Paramagnetic species M of the mixed complexes of the invention broadly include paramagnetic ions having a cationic charge of at least two, and especially trivalent ions of the lantha... Read More
Inventors: Matwiyoff, Nicholas A.;, Assignee: The University of New Mexico (Albuquerque, NM) |
Contrast agents for magnetic resonance imaging of the small intestine and hepatobiliary system
What is claimed is: 1. A metal complex comprising a metal ion selected from the group consisting of Fe(III), Dy(III), Gd(III), Cr(III) and Mn(II) and a ligand of the formula ##STR5## wherein R is -des... Read More
Inventors: White, David L.; Engelstad, Barry L.; Muetterties, Kurt A.;, Assignee: The Regents of the University of California (Oakland, CA) |
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Vasodialators 
