Process for producing nicotinic acid
In FIG. 1, No. I and No. II show a reactor and No. III shows a receiving tank of reaction solution. No. 1 is a charging inlet of raw material, No. 2 is an introducing inlet feeding a reaction solutio... Read More
Inventors: Masuda, Keiji; Kizawa, Hidenori; Otaki, Yasuhiko;, Assignee: Nippon Soda Company Limited (Tokyo, JA) |
Pharmaceutical compositions and method of treatment employing 1,3-dioxo-2,2-disubstituted indanyloxy alkanoic acids
What is claimed is: 1. A pharmaceutical composition useful in the treatment of edema and hypertension which also maintains uric acid at pretreatment levels or causes a decrease in uric acid in patient... Read More
Inventors: Cragoe, Jr., Edward J.; Woltersdorf, Jr., Otto W.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Synergistic microbecidal composition and method
OF THE INVENTION The present invention is based upon several primary discoveries. A first and most-basic discovery is that the esters of the said earlier applications have the unexpected and unusual ... Read More
Inventors: Kabara, Jon J.;, Assignee: Med-Chem Laboratories (Okemos, MI) |
Fungicidal compositions based on phosphorous acid esters and salts thereof
We claim: 1. A fungicidal composition for controlling fungus disease in plants comprising as an active material, a fungicidally effective quantity of at least one compound of the formula ##STR58## in ... Read More
Inventors: Ducret, Jacques; Lacroix, Guy; Gaulliard, Jean-Michel;, Assignee: PEPRO (FR) |
Process for the esterification of terephthalic acid in the gas phase
We claim: 1. In the continuous method for the preparation of dimethyl terephthalate by the esterification of terephthalic acid with methanol in the gas phase at temperatures between about 280.degree. ... Read More
Inventors: Wulf, Horst-Dieter; List, Ferdinand; Orlowski, Friedrich-August; Wilke, Norbert; Pflegerl, Emmerich;, Assignee: Chemische Werke Huls Aktiengesellschaft () |
Physiologically active peptide
What is claimed is: 1. A peptide having the primary structural formula: ##STR6## in which X is Met and Y is OH, Lys-OH, Arg-OH, Lys-Arg-OH or Lys-NH2 or X is Leu and Y is Lys-NH2, Lys-OH or Lys-Arg-OH... Read More
Inventors: Ito, Osamu; Tachibana, Shinro;, Assignee: Eisai Co., Ltd. (Tokyo, JP) |
In vitro method of inhibition of HIV using transforming growth factor-.beta .
OF THE INVENTION The present invention is directed to a method for inhibiting HIV infection and/or replication using TGF-.beta.. The invention is based upon the discovery that both mature and precurs... Read More
Inventors: Brankovan, Vera; Lioubin, Mario N.; Purchio, Anthony F.;, Assignee: Oncogen (Seattle, WA) |
Methods for increasing levels of acetylcholine
We claim: 1. A pharmaceutical formulation comprising a compound of formula I: ##STR3## or a pharmaceutical acid addition salt or solvate thereof; where: R.sup.1 and R.sup.3 are independently hydrogen,... Read More
Inventors: Bryant, Henry Uhlman; Glinn, Michele Annette; Paul, Steven Marc; Wu, Xin;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
N-organooxycarbamic acid esters for combating endoparasites
What is claimed is: 1. A method of combating endoparasites which comprises applying thereto or to an endoparasite habitat an endoparasiticidally effective amount of an N-organooxycarbamic acid ester o... Read More
Inventors: Muller, Nikolaus; Andrews, Peter;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
Pyrimidone derivatives
We claim: 1. Compounds of the formula (1): ##STR14## and physiologically acceptable acid addition salts, and hydrates thereof, in which R.sub.1 and R.sub.2 which may be the same or different, each rep... Read More
Inventors: Price, Barry J.; Clitherow, John W.; Bradshaw, John; Martin-Smith, Michael; Judd, Duncan B.; Hayes, Roger;, Assignee: Glaxo Group Limited (London, GB2) |
3-Carboalkoxy (or phenoxy) and 3-thiocarbo-(3-chloro-2-propenyl)-1,3,5,7-tetraazabicyclo(3.3.1)nonane and preparation
What is claimed is: 1. A compound corresponding to the formula ##STR5## wherein X represents O or S and R represents C.sub.1-4 alkyl, phenyl or (C.sub.1-4 alkyl)phenyl. 2. The compound of claim 1 wher... Read More
Inventors: Paul, Albertha M.; Moppett, Charles E.;, Assignee: The Dow Chemical Company (Midland, MI) |
Apparatus for classifying liquid mixture in accordance with molecular weight
OF THE INVENTION An apparatus for classifying liquid mixture in accordance with molecular weight comprises a vessel 1 (FIG. 1) for liquid mixture to be separated, and a pump 2 is provided for feeding... Read More
Inventors: Kornilov, Anatoly A.; Petrushkin, Viktor D.; Stetsko, Viktor N.; Fridman, Viktor M.;, Assignee: |
1,2,3,4-Tetrahydro-4-oxo-1-naphthylisocyanate
I claim: 1. A compound of the formula: ##SPC8## wherein X is oxygen, the racemic mixture and the optical isomers thereof. 2. The racemic mixture according to claim 1, wherein X is oxygen; 1,2,3,4-tetr... Read More
Inventors: Asato, Goro;, Assignee: American Cyanamid Company (Stamford, CT) |
Process for preparing iminodiacetonitrile
OF THE INVENTION The following equation shows the stoichiometry of the formation of IDAN from HMTA in the presence of sulfuric acid (other strong acid can be substituted for H.sub.2 SO.sub.4): ##EQU1... Read More
Inventors: Cullen, Barry Allen;, Assignee: W. R. Grace & Co. (New York, NY) |
Derivatives of 2-oxazolydone and methods for preparing the same
What is claimed is: 1. A member selected from the group consisting of 3-isopropyl-5-(1-naphthyloxymethyl)-2-oxazolydone; 3-isopropyl-5-(4-acetaminophenoxymethyl)-2-oxazolydone; 3-isobutyl-5-{2[(tetrah... Read More
Inventors: Pestellini, Vittorio; Ghelardoni, Mario; Bianchini, Claudio; Del Soldato, Piero; Volterra, Giovanna; Meli, Alberto;, Assignee: A. Menarini S.A.S. (IT) |
5-Heteroarylimidazol-2-ones having cardiotonic activity
OF THE INVENTION The compounds of the invention can be made by the following described method, the reaction scheme illustrating a representative procedure. ##STR5## In order to illustrate the manner ... Read More
Inventors: Stout, David M.; Yamamoto, Diane M.;, Assignee: American Hospital Supply Corporation (Evanston, IL) |
Dihydrooxadiazinones and method for making
What I claim as new and desire to secure by Letters Patent of the United States is: 1. The compound 5-phenyl-3,6-dihydro-1,3,4-oxadiazin-2-one.
Description:
The present invention relates ... Read More
Inventors: Niznik, George E.;, Assignee: General Electric Company (Schenectady, NY) |
Process for the preparation of 5-(4-amino butyl)-hydantoin and/or 2-ureido-6-amino-hexanoic acid amide
We claim: 1. An improved process for the preparation of 5-(4-aminobutyl)-hydantoin by the hydrogenation of 5-(3-cyanopropyl)-hydantoin in a liquid phase in the presence of a hydrogenation catalyst, hy... Read More
Inventors: Vandenbooren, Franciscus H. A. M. J.; Verheijen, Egidius J. M.;, Assignee: Stamicarbon, B.V. (Geleen, NL) |
Certain 5,6-dihydra-prostacyclin analogs
It is the purpose of this invention to provide novel products having pharmacological activity. It is a further purpose to provide processes for preparing these products and their intermediates. The pr... Read More
Inventors: Nelson, Norman A.;, Assignee: The Upjohn Company (Kalamazoo, MI) |
Ketoalkanesulfenyl and ketoalkanethiosulfenyl carbamates
What is claimed is: 1. A compound of the formula: ##STR52## wherein: n is 1 or 2; R.sub.1 is alkyl; R.sub.2 is alkyl or chlorine; R.sub.3 is hydrogen, alkyl, phenyl, alkoxycarbonyl, alkanoyl or phenox... Read More
Inventors: D'Silva, Themistocles D. J.;, Assignee: Union Carbide Corporation (New York, NY) |
Piperidylbenzimidazolinone compounds
We claim: 1. A compound selected from the group consisting of: piperidylbenzimidazolinone compounds of the formula: ##STR18## in which: R is selected from the group consisting of hydrogen, hydroxy (OH... Read More
Inventors: Regnier, Gilbert; Dhainaut, Alain; Duhault, Jacques; Boulanger, Michelle;, Assignee: Science Union et cie, Societe Francaise de Recherche Medicale (Suresnes, FR) |
False twist machine
That which is claimed is: 1. In a friction false twist yarn producing machine having a primary heater, a cooling zone, a secondary heater and a means to take up treated yarn, the improvement comprisin... Read More
Inventors: King, Jerry N.;, Assignee: Milliken Research Corporation (Spartanburg, SC) |
1-Benzoyl-3-(aryloxy- or arylthiopyridinyl) urea compounds
OF THE INVENTION For the purposes of the present application, the compounds of this invention are named as substituted ureas, with numbering as follows: ##STR5## Thus, the comounds are named as 1-(2-... Read More
Inventors: Suhr, Robert G.; Miesel, John L.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
1-Hydroxymethyl-1-oxo-prostane derivatives of the F.sub.1 series
OF THE INVENTION EXAMPLE 1 Preparation of ethyl 2,2-trimethylenehexanoate To a stirred solution of 27.6 g of freshly distilled N-isopropylcyclohexylamine in 200 ml of dry tetrahydrofuran cooled to -7... Read More
Inventors: Wissner, Allan;, Assignee: American Cyanamid Company (Stamford, CT) |
Naphthalene-1,5-disulfonate salts of dimeric indole-dihydroindole alkaloids
We claim: 1. A 1,5-naphthalenedisulfonate salt of an indole-dihydroindole alkaloid of the formula ##STR2## wherein R.sup.1 is OH or O--CO--CH.sub.3, R.sup.2 is CH.sub.3 or CHO; one of R.sup.3 and R.su... Read More
Inventors: Rolski, Stanislaw; Pfeiffer, Ralph R.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Antipsycotic benzoxazines
OF THE INVENTION "Pharmaceutically acceptable salts" refers to the salts which retain the biological effectiveness and properties of the free bases and which are not biologically or otherwise undesid... Read More
Inventors: Bernardi, Luigi; Lazzari, Ettore; Malnati, Maria L.; Mazzini, Giuseppe; Pegrassi, Lorenzo; Rossi, Alessandro;, Assignee: Farmitalia Carlo Erba S.p.A. (Milan, IT) |
Novel prostanoic acid derivatives and processes for the preparation thereof
What is claimed is: 1. A prostaglandin of the formula ##SPC10## wherein R.sub.1 is hydroxymethyl, carboxyl, alkoxycarbonyl of 1-8 carbon atoms in the alkoxy group, of --COO--CH.sub.2 --X--Y wherein X ... Read More
Inventors: Raduchel, Bernd; Skuballa, Werner; Vorbruggen, Helmut; Elger, Walter; Losert, Wolfgang; Loge, Olaf;, Assignee: Schering Aktiengesellschaft (Berlin & Bergkamen, DT) |
Novel prostanoic acid derivatives and process for the preparation thereof
What is claimed is: 1. A prostaglandin of the formula ##STR51## wherein R.sub.1 is hydroxymethyl, carboxy, aryloxycarbonyl, alkoxycarbonyl of 1-8 carbon atoms in the alkoxy group, or the group -COO-CH... Read More
Inventors: Skuballa, Werner; Raduchel, Bernd; Vorbruggen, Helmut; Elger, Walter; Losert, Wolfgang; Loge, Olaf;, Assignee: Schering Aktiengesellschaft (Berlin & Bergkamen, DT) |
Prostaglandin intermediates and processes for preparation of prostaglandin intermediates
I claim: 1. The process for the preparation of intermediates useful in the production of prostaglandins, the steps which comprise subjecting a compound corresponding to the formula ##STR20## where R.s... Read More
Inventors: Libit, Lawrence;, Assignee: |
Hemostatic compositions comprising salts of substituted hydroquinone sulfonic acid
I claim: 1. A medicament having a hemostatic effect and a protective effect on the capillaries, comprising a pharmaceutically acceptable carrier and a hemostatically effective amount of a compound of ... Read More
Inventors: Esteve-Subirana, Antonio;, Assignee: Laboratorios del Dr. Esteve, S.A. (Barcelona, ES) |
Vasodialators 
