Heat stable alkaline proteases produced by a bacillus
OF THE INVENTION The present invention is directed to novel enzymes possessing proteolytic activity under alkaline conditions, at least one of which exhibits a high degree of alkaline and thermal sta... Read More
Inventors: Stellwag, Edmund J.; Durham, Donald R.; Swann, Wayne E.; Nolf, Carol A.; Stewart, David B.;, Assignee: Genex Corporation (Gaithersburg, MD) |
8.beta.,12.alpha.,15.beta.-PGF.sub.2 .beta. Compounds
I claim: 1. An optically active compound of the formula ##STR107## wherein R.sub.4, R.sub.5, and R.sub.7 are hydrogen or methyl, being the same or different; wherein R.sub.13 is hydrogen, alkyl of one... Read More
Inventors: Yankee, Ernest W.;, Assignee: The Upjohn Company (Kalamazoo, MI) |
Azaprostanoic acid analogs and their use as inhibitors of platelet aggregation
The following examples illustrate preparation of 13-azaprostanoic acid analogs of the formula II ##STR14## wherein: R is C.sub.1 to C.sub.8 alkyl or benzyl. More specifically the examples illustrate ... Read More
Inventors: Venton, Duane L.; Le Breton, Guy C.; Enke, Steven E.;, Assignee: The University of Illinois Foundation (Urbana, IL) |
Bicycloheptane substituted diamide and its congener prostaglandin analogs
What is claimed is: 1. A compound having the structure ##STR95## including all stereoisomers thereof, wherein m is 0 to 4; A is --CH.dbd.CH-- or --CH.sub.2 --CH.sub.2 --; n is 1 to 5; Q is --CH.dbd.CH... Read More
Inventors: Hall, Steven E.; Reid, Joyce;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Urinary drainage device
What is claimed is: 1. A urinary drainage device adapted for wear by male or female patients with indwelling or external catheters, said device comprising: a flexible container having a first end and ... Read More
Inventors: Mervine, Jeanne A.;, Assignee: Rehabilitation Institute of Chicago (Chicago, IL) |
6 Alpha, 6 beta-difluoro-etianic acid derivatives
AND PREFERRED EMBODIMENTS Compounds In its broadest aspect, this invention is a compound chosen from those represented by formula (I), above, wherein X.sup.1 is hydrogen, fluoro, chloro or bromo; X.s... Read More
Inventors: Edwards, John A.; Alvarez, Francisco S.;, Assignee: Syntex (U.S.A.) Inc. (Palo Alto, CA) |
Method for the treatment of systemic mycosis
OF THE INVENTION The (S)-2-amino-5-hydroxy-4-oxopentanoicacid which may be employed for the present method for the treatment of systemic mycosis is a substance known per se and can be obtained, for e... Read More
Inventors: Watanabe, Naoharu; Numata, Kazuo; Yamagishi, Michio; Mizutani, Taku; Omura, Sadafumi; Yamaguchi, Hideyo;, Assignee: Taisho Pharmaceutical Co., Ltd. (JP) |
Diaper with repositionable tab fastener
I claim: 1. A disposable diaper having a facing sheet defining a diaper inside surface for direction toward an infant, a moisture-impervious backing sheet substantially coextensive with said facing sh... Read More
Inventors: Cepuritis, Talivaldis;, Assignee: Johnson & Johnson (New Brunswick, NJ) |
Peptic ulcer treatment method
OF THE INVENTION Two previously discussed mechanisms are believed to play important roles in the antipeptic ulcer activity of prostaglandins and synthetic prostaglandin analogs and congeners. Those m... Read More
Inventors: Rosenthale, Marvin E.; Shriver, David A.; Katz, Laurence B.;, Assignee: Ortho Pharmaceutical (Raritan, NJ) |
Transdermal administration of buprenorphine
I claim: 1. A laminated composite for administering buprenorphine hydrochloride to an individual transdermally comprising: (a) a polymer backing layer that is substantially impermeable to buprenorphin... Read More
Inventors: Sharma, Kuldeepak; Roy, Samir D.; Roos, Eric J.;, Assignee: Cygnus Therapeutic Systems (Redwood City, CA) |
Apparatus delivering nitroglycerin to the skin, process for the production thereof and use thereof
The invention relates to an apparatus for the controlled delivery or release of nitroglycerin to the human or animal skin, preferably in plaster form, with a backing layer impermeable to the nitroglyc... Read More
Inventors: Jaeger, Halvor; Hoffmann, Hans-Rainer; Meconi, Reinhold; Klein, Robert-Peter;, Assignee: LTS Lohmann Therapie-Systems GmbH & Co. KG (Neuwied, DE) |
Procaterol-containing preparation for application to the skin
We claim: 1. A procaterol-containing preparation for application to the skin which comprises a drug-retaining layer provided on a support, wherein said drug-retaining layer is a substantially water-fr... Read More
Inventors: Akazawa, Mitsuji; Hama, Teruo; Kimura, Yukio; Yasuda, Yoshinobu;, Assignee: Teikoku Seiaku Kabushiki Kaisha (Kagawa, JP) |
Penetration enhancers for transdermal delivery of systemic agents
OF THE INVENTION The compounds useful as membrane penetration-enhancers in the formulations or devices of the instant invention may be made as described in U.S. patent application Ser. No. 825,041 he... Read More
Inventors: Minaskanian, Gevork; Peck, James V.; Rajadhyaksha, Vithal J.;, Assignee: Whitby Research, Inc. (Richmond, VA) |
Prostaglandin derivatives
OF THE INVENTION Throughout the specification, it will be understood by those skilled in the art that all isomers are included in the present invention. For example, the term "alkyl group" includes s... Read More
Inventors: Nishiura, Akio; Seko, Takuya; Matsumoto, Ryoji; Hamano, Shin-ichi;, Assignee: Ono Pharmaceutical Co., Ltd. (Osaka, JP) |
Saccharin derivative proteolytic enzyme inhibitors
OF THE INVENTION INCLUSIVE OF THE PREFERRED EMBODIMENTS The Compounds and Their Preparation Saccharin is 1,2-benzisothiazol-(1H)-3-one-1,1dioxide and the compounds of Formula I, which are 2-(R.sup.1 ... Read More
Inventors: Dunlap, Richard Paul; Mura, Albert Joseph; Hlasta, Dennis John; Desai, Ranjit Chimanlal; Latimer, Lee Hamilton;, Assignee: Sanofi (Paris Cedex, FR) |
Pharmaceutical preparations for induction of labor and for contraceptive use
I claim: 1. A pharmaceutical composition useful as a contraceptive and in the induction of labor comprising a therapeutically effective amount of at least one antigestagen and one or more long-chain f... Read More
Inventors: Weithmann, Klaus U.;, Assignee: Hoechst Aktiengesellschaft (DE) |
Mercapto-acylamino acids
As used herein, the term "lower alkyl" means straight or branched alkyl chains of 1 to 6 carbon atoms, and "lower alkoxy" similarly refers to alkoxy groups having 1 to 6 carbon atoms. Cyclolower alky... Read More
Inventors: Smith, Elizabeth M.; DeCapite, Philip M.; Neustadt, Bernard R.;, Assignee: Schering Corporation (Kenilworth, NJ) |
Method for effecting vasodilation with monoglycerides
OF THE INVENTION The Compounds Of The Invention And Preparation Thereof The present invention provides a class of compounds useful in stimulating vasodilation. These compounds can be represented by t... Read More
Inventors: Spiegelman, Bruce M.; Wilkison, William O.; Bursell, Sven;, Assignee: Joslin Diabetes Center (Boston, MA); Dana-Farber Cancer Institute (Boston, MA) |
Methods for treating neoplastic conditions using phenylacetic acid and derivatives thereof
The invention provides a method of treating various pathologies in a subject. The invention also provides for the modulation of various cellular activities in a subject. The pathologies and cellular a... Read More
Inventors: Samid, Dvorit;, Assignee: The United States of America as represented by the Department of Health (Washington, DC) |
Adjuvant for promoting absorption of pharmacologically active substances through the rectum
What we claim is: 1. A pharmacologically-acceptable composition comprising, in intimate admixture, (a) a base suitable for rectal administration of a pharmaceutical and (b) an absorption-promoting amo... Read More
Inventors: Kitao, Kazuhiko; Nishimura, Ken-ichi;, Assignee: Kyoto Yakuhin Kogyo Kabushiki Kaisha (Kyoto, JP) |
N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) as hypercholesterolemic agents
OF THE INVENTION The compounds of the present invention provide a novel class of N-acyl sulfamic acid esters (or thioesters), N-acyl sulfonamides, and N-sulfonyl carbamic acid esters (or thioesters) ... Read More
Inventors: Lee, Helen T.; Picard, Joseph A.; Sliskovic, Drago R.; Wierenga, Wendell;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Anti-acne composition
OF THE INVENTION This invention relates to antibiotic compositions especially adapted for the treatment of Acne vulgaris and other acneiform skin diseases. The compositions herein comprise a safe and... Read More
Inventors: Thompson, Edward D.; Carter, Stephen B.; Manring, Gary L.;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Transdermal contraceptive formulations
What is claimed is: 1. A composition of matter for the transdermal administration of a drug formulation comprised of ethinyl estradiol and levonorgestrel, comprising a matrix containing said drug form... Read More
Inventors: Nedberge, Diane E.; Campbell, Patricia S.; Gale, Robert M.; Yum, Su I.;, Assignee: ALZA Corporation (Palo Alto, CA) |
Subsaturated transdermal therapeutic system having improved release characteristics
We claim: 1. A method of producing a therapeutic effect which comprises placing a source of benztropine comprising a benztropine base permeable material having benztropine dissolved therein in benztro... Read More
Inventors: Enscore, David J.; Campbell, Patricia S.; Osborne, James L.; Smart, Melinda K.; Yum, Su I.;, Assignee: ALZA Corporation (Palo Alto, CA) |
Prolonged activity nicotine patch
The present invention is a transdermal patch that can hold and deliver sufficient nicotine to be effective for a period of 12 hours or more, preferably 24 hours. The patch therefore enables the major ... Read More
Inventors: Baker, Richard W.; Kochinke, Frank; Huang, Carl;, Assignee: Pharmetrix Corporation (Menlo Park, CA) |
Subsaturated nicotine transdermal therapeutic system
It is accordingly an object of this invention to provide a rate controlled transdermal nicotine delivery device having an in-line adhesive and a subsaturated nicotine reservoir, which device exhibits ... Read More
Inventors: Osborne, James L.; Nelson, Melinda; Enscore, David J.; Yum, Su I.; Gale, Robert M.;, Assignee: ALZA Corporation (Palo Alto, CA) |
Transdermal formulations, methods and devices
An object of the present invention is to provide delivery of estrogens and ST-1435 by means of transdermal devices. A further object of the invention is to co-administer estrogens and ST-1435 transder... Read More
Inventors: Gale, Robert M.; Nedberge, Diane E.; Atkinson, Linda E.;, Assignee: Alza Corporation (Palo Alto, CA) |
Transdermal administration of oxybutynin
According to the present invention, it has been discovered that oxybutynin may be safely and efficaciously administered transdermally, together with a suitable permeation enhancer, preferably a monogl... Read More
Inventors: Lee, Eun S.; Nedberge, Diane E.; Yum, Su I.;, Assignee: ALZA Corporation (Palo Alto, CA) |
Method and pacemaker for stimulating penile erection
We claim: 1. A method for stimulating penile erection in a human male comprising the steps of identifying the anatomical location of at least one cavernous nerve of a penis, implanting electrode means... Read More
Inventors: Lue, Tom P.; Tanagho, Emil A.; Schmidt, Richard A.;, Assignee: Regents of University of California (Berkeley, CA) |
Method for passing information between a patient's auditory cortex and a speech processor
It is therefore an object of the invention to provide a wireless prosthetic which can be placed in a cerebral cortex to reconstitute sensor input to the brain using microstimulation. Another object of... Read More
Inventors: Howard, III, Matthew A.;, Assignee: The University of Iowa Research Foundation (Iowa City, IA) |
Vasodialators 
