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| Latest patents |
Results: 61-90 of 1119
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Substituted and bridged pyridines useful as calcium channel blockers
OF THE INVENTION The specific substituted and bridged pyridine compounds of this invention are represented by the following general structural formula (I): ##STR1## wherein: n is 0, 1 or 2; A is oxyg... Read More
Inventors: Hartman, George D.; Phillips, Brian T.;, Assignee: Merck & Co., Inc. (Rahway, NY) |
Ace inhibitors in macular degeneration
OF THE INVENTION The novel method of treatment of senile macular degeneration of this invention comprises the administration to a patient in need of such treatment of an effective amount of an angiot... Read More
Inventors: Veber, Daniel F.; Baldwin, John J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Derivatives of 2,3,4,5,6,7-hexahydro-2,7-methano-1,5-benzoxazonines and -1,4-benzoxazonines, processes for their production and their use as pharmaceuticals
We claim: 1. 2,3,4,5,6,7-Hexahydro-2,7-methano-1,5-benzoxazonine and -1,4-benzoxazonine compounds, of the formula ##STR15## wherein: R.sub.1 is hydrogen or C.sub.1 -C.sub.4 alkyl; one of R.sup.2 and R... Read More
Inventors: Eiden, Friedrich; Gmeiner, Peter; Schunemann, Jurgen;, Assignee: Madaus GmbH & Company (Cologne, DE) |
Novel benzylalcohol derivatives and processes for preparing the same
What we claim is: 1. A compound of the formula: ##STR11## wherein R is a lower alkyl group having 1-4 carbon atoms, or a pharmaceutically acceptable acid addition salt thereof. 2. The compound of clai... Read More
Inventors: Ikezaki, Muneyoshi; Okazaki, Yashushi; Ito, Nobuo; Hoshiyama, Masao; Nagao, Taku; Nakajima, Hiromichi;, Assignee: Tanabe Seiyaku Co., Ltd. (Osaka, JP) |
Method of use of bicycloheptane substituted prostaglandin analogs as cardiovascular agents
What is claimed is: 1. A method of inhibiting arachidonic acid-induced platelet aggregation and bronchoconstriction, which comprises administering to the circulatory system of a mammalian host an effe... Read More
Inventors: Sprague, Peter W.; Loots, Melanie J.; Haslanger, Martin F.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
1-arylsulphonyl-2-piperidinone derivatives, process and intermediates for the preparation thereof, their application as antispasmodics and compositions containing them
What is claimed is: 1. The compound of formula (I): ##STR11## in which R represents the radical ##STR12## in which R.sub.1 at any position on the benzene ring represents linear, branched or cyclic alk... Read More
Inventors: Toja, Emilio; Barzaghi, Fernando; Galliani, Giulio;, Assignee: Roussel Uclaf (Paris, FR) |
Dihydropyridine derivatives and pharmaceutical composition thereof
OF THE INVENTION This invention relates to dihydropyridine derivatives represented by the formula (I) ##STR2## wherein R.sub.1, R.sub.2 and R.sub.3 are the same or different and each is alkyl, cycloa... Read More
Inventors: Ashimori, Atsuyuki; Ono, Taizo; Inoue, Yoshihisa; Fukaya, Chikara; Yokoyama, Kazumasa;, Assignee: The Green Cross Corporation (Higashi, JP) |
1-[2-(1H-inden-3-yl)ethyl]-4-(naphth-1-yl)piperazine derivatives, their preparation and their application in therapeutics
We claim: 1. A compound of the formula: ##STR6## in which X represents a hydrogen atom, a C.sub.1 -C.sub.3 alkoxy group or a cyclopropylmethoxy group, and Y represents a hydrogen atom or a methoxy gro... Read More
Inventors: Manoury, Phillip; Obitz, Daniel; Peynot, Michel; Sevrin, Mireille; George, Pascal;, Assignee: Synthelabo (Le Plessis Robinson, FR) |
Use of fedotozine in the treatment of functional states of intestinal obstructions
We claim: 1. Process for inhibiting functional ileus in a patient, which consists of administering a therapeutically effective dose of (+)-1-[(3,4,5-trimethoxy)benzyloxymethyl]-1-phenyl-N,N-dimethylpr... Read More
Inventors: Riviere, Pierre J. M.; Pascaud, Xavier B.; Roman, Francois J.; Junien, Jean-Louis;, Assignee: |
Manufacture of pharmaceutical dosage forms
OF THE INVENTION The present invention is directed to solid, unit dosage forms primarily for oral ingestion which are advantageous in a number of particulars over present solid oral dosage forms, i.e... Read More
Inventors: Dabal, Dennis J.; Williams, Joseph J.;, Assignee: Hoffmann-La Roche Inc. (Nutley, NJ) |
Device comprising liner for protecting fluid sensitive medicament
OF THE DRAWING FIGURES Turning now to the drawings in detail, which are examples of various delivery devices provided by the invention and which examples are not to be construed as limiting, one exam... Read More
Inventors: Eckenhoff, James B.; Magruder, Judy A.; Cortese, Richard; Peery, John R.; Wright, Jeremy C.;, Assignee: ALZA Corporation (Palo Alto, CA) |
In situ active compound assembly
I claim: 1. A method to modify a target condition contained within an environment with a conjugate active in modifying said target condition which conjugate comprises at least two components which met... Read More
Inventors: Rideout, Darryl C.;, Assignee: Scripps Clinic and Research Foundation (La Jolla, CA) |
Inhibition of nitric oxide-mediated hypotension and septic shock with iron-containing hemoprotein
The invention is directed to a method for the prophylaxis or treatment of an animal for systemic hypotension or other pathogenic syndromes induced by inappropriate nitric oxide production. Such hypote... Read More
Inventors: Kilbourn, Robert G.; De Angelo, Joseph; Bonaventura, Joseph;, Assignee: Board of Regents, The University of Texas System (Austin, TX); Strohtech, Inc. (Detroit, MI); Duke University (Durham, NC) |
Use of cardiotonic drugs and inhibitors of nitric oxide synthesis to alleviate pathologic hypotension
The present invention involves a method for prophylaxis or treatment of an animal for systemic hypotension induced by endotoxin and/or a biological response modifier such as the cytokines, IFN, TNF, I... Read More
Inventors: Kilbourn, Robert G.; Gross, Steven S.; Griffith, Owen W.;, Assignee: Board of Regents, the University of Texas System (Austin, TX); Cornell Research Foundation, Inc. (Ithaca, NY) |
Anti-endotoxin, interleukin-1 receptor antagonist and anti-tumor necrosis factor antibody with arginine-free formulations for the treatment of hypotension
The inventors herein propose uses of anti-TNF antibodies, anti-endotoxin antibodies, and cytokine receptor antagonists (e.g., IL-1 receptor antagonist) in combination with arginine-free formulations i... Read More
Inventors: Kilbourn, Robert G.; Griffith, Owen W.; Gross, Steven S.;, Assignee: Board of Regents, The University of Texas System (Austin, TX) |
Anti-bronchoconstriction 2-(4'-pyridinyl)-thiazole derivatives, composition, and method of use therefor
We claim: 1. A compound having the structural formula I ##STR4## wherein R is cyano, ##STR5## --C(.dbd.X)NHY wherein X is O, S or NH; and Y is hydrogen, hydroxy, alkyl having from 1 to 6 carbon atoms,... Read More
Inventors: Sunday, Brooks R.; Witkowski, Joseph T.;, Assignee: Schering Corporation (Kenilworth, NJ) |
Aromatic benzamido compounds; their preparation and their use in human or veterinary medicine or in cosmetic preparations
What is claimed is: 1. A pharmaceutical composition comprising in a vehicle suitable for enteral, parenteral, topical or ocular administration, at least one aromatic benzamido compound having the form... Read More
Inventors: Shroot, Braham; Eustache, Jacques; Bernardon, Jean-Michel;, Assignee: Centre International de Recherches Dermatogologiques (C.I.R.D.) (Valbonne, FR) |
Antioxidant-induced apoptosis in vascular smooth muscle cells
The invention is based on the discovery that, unlike other cell types, vascular smooth muscle cells which contribute to the development of arteriosclerosis are induced to undergo apoptosis upon exposu... Read More
Inventors: Lee, Mu-En; Haber, Edgar; Tsai, Jer-Chia;, Assignee: President and Fellows of Harvard College (Cambridge, MA) |
Treatment of climacteric disorders with nitric oxide synthase substrates and/or donors
In a method aspect, this invention relates to a method of treating the climacterium symptoms in a non-pregnant female or in a male mammal which comprises administering to an individual manifesting the... Read More
Inventors: Garfield, Robert E.; Chwalisz, Krzysztof; Bukowski, Radoslaw; Yallampalli, Chandra;, Assignee: Schering Aktiengesellschaft (DE); Board of Regents, University of Texas (Austin, TX) |
Microbial hair tonic composition
We claim: 1. A microbial hair treatment composition comprising 10.sup.6 to 10.sup.8 cells/ml of cultured living Staphylococcus capitis and a suitable solvent. 2. The microbial hair treatment compositi... Read More
Inventors: Yoshizumi, Hajime; Amachi, Teruo; Kusumi, Takaaki; Tanaka, Takaharu; Ishigooka, Hiroshi;, Assignee: Suntory Limited (Osaka, JP) |
Hair treating composition
OF THE INVENTION The formulation of 9 parts d-panthenyl ethyl ether and 1 part d-panthenol can be incorporated in hair conditioning or treating compositions in an amount generally of from about 0.05%... Read More
Inventors: Maes, Daniel; Brudney, Norman;, Assignee: Richardson-Vicks Limited (Egham, GB2) |
Hair cosmetic composition
We claim: 1. A composition of matter in the form of a solution, comprising: (a) a solvent including ethanol; (b) a hair-growing component which is at least one compound selected from the group consist... Read More
Inventors: Oono, Tooru; Nishida, Yuichi;, Assignee: Lion Corporation (JP) |
Anti-thrombogenic, anti-microbial compositions containing heparin
OF THE INVENTION The compositions of the present invention are first dissolved in solvent mixtures that are co-solvents for the mixtures of non-volatile components and which allow compatible homogeno... Read More
Inventors: Whitbourne, Richard J.; Mangan, Margaret A.;, Assignee: Sterilization Technical Services, Inc. (Rochester, NY) |
Derivative-compound-conjugates and pharmaceutical compositions comprising same
OF THE INVENTION The introduction of molecules of diagnostic, prophylactic, or therapeutic interest across body surfaces and/or into cells requires the transversal of one or more semi-permeable biolo... Read More
Inventors: Kahne, Daniel E.; Walker Kahne, Suzanne;, Assignee: The Trustees of Princeton University (Princeton, NJ) |
Vincamine derivatives and process for the preparation of vincamine and derivatives thereof
Having now described our invention what we claim as new and desire to secure by Letters Patent is: 1. 20-Deethyl-apovincamine, having the formula: ##SPC7## under its racemic and optically active forms... Read More
Inventors: Sevenet, Thierry; Thal, Claude; Husson, Henri Philippe; Potier, Pierre;, Assignee: Agence Nationale de Valorisation de la Recherche (ANVAR) (Neuilly-sur-Seine, FR) |
Naphthyridine derivatives and their use as anti-bacterials
What we claim is: 1. A 1,8-naphthyridine compound of the formula ##STR9## wherein R is vinyl or 2-fluoroethyl, R.sub.1 and R.sub.2 are the same or different and each represents a hydrogen atom or lowe... Read More
Inventors: Matsumoto, Jun-ichi; Nakamura, Shinichi;, Assignee: Dainippon Pharmaceutical Co., Ltd. (Osaka, JP); Laboratoire Roger Bellon (Neuilly-sur-Seine, FR) |
Indole derivatives
We claim: 1. A compound of formula (I) ##STR11## wherein R.sup.1 and R.sup.2 each represents a hydrogen atom or a C.sub.1-6 alkyl group, Z represents a ring selected from: ##STR12## in which n represe... Read More
Inventors: Forner, Dolors F.; Duran, Carles P.; Soto, Jose P.; Noverola, Armando V.; Mauri, Jacinto M.;, Assignee: Laboratorios Almirall S.A. (ES) |
4-(3-(4-Quinolyl)propyl)piperidines, their preparation and their use as medicines
What is claimed is: 1. A method for the treatment of a mammal afflicted with a disturbance in the functioning of serotoninergical systems which comprises administering to said mammal a therapeutically... Read More
Inventors: Champseix, Alain A.; Gueremy, Claude G. A.; Le Fur, Gerard R.;, Assignee: Pharmindustrie (Gennevilliers, FR) |
Derivatives of 1-(2-,3- or 4-quinolyl)-2- or -3-(2- or 3-piperidyl or -pyrrolidinyl) ethanone or propanone, and their utilization as antiarrhythmics, anticonvulsivants and for the treatment of anxiety
What is claimed is: 1. Compounds of the formula: ##STR30## in which R is fixed in position 2 or 4 on the cycle of the quinoline and represents a phenyl, pyridyl or thienyl group, or a phenyl group sub... Read More
Inventors: Dubroeucq, Marie-Christine; Gueremy, Claude G. A.; Le Fur, Gerard R.; Mizoule, Jacques;, Assignee: Pharmindustrie (Gennevilliers, FR) |
1,2,4-Triazoles
What is claimed is: 1. A compound of the formula: ##STR5## and non-toxic salts thereof, wherein R.sub.1 is hydrogen, C.sub.1-5 alkyl, C.sub.2-5 alkanoyl, phenyl -C.sub.1-5 alkyl, carbamoyl C.sub.1-5 a... Read More
Inventors: Baldwin, John J.; Novello, Frederick C.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
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Vasodialators 
