7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation
OF THE INVENTION The compounds of the instant invention comprise those of Formula I ##STR15## wherein R.sub.1 is hydrogen, lower alkyl; R.sub.2 is hydrogen, lower alkyl, lower alkoxy, halogen; R.sub.... Read More
Inventors: Meanwell, Nicholas A.; Wright, John J.;, Assignee: Bristol-Myers Company (New York, NY) |
Imidazo[4,5-b]quinolinyloxyalkanoic acid amides with enhanced water solubility
OF THE INVENTION The compounds of the instant invention comprise those of Formula I ##STR13## wherein n is 3 to 5; R.sub.1 is alkyl of 1 to 4 carbon atoms; R.sub.2 is hydrogen; R.sub.3 is 1-piperidin... Read More
Inventors: Meanwell, Nicholas A.;, Assignee: Bristol-Myers Squibb Company (New York, NY) |
Nocardia species capable of producing nargenicin C.sub.1
OF THE INVENTION The antibiotic of this invention, nargenicin C.sub.1, is produced by fermentation of a new microorganism designated as culture N467-32, which was obtained from a soil sample collecte... Read More
Inventors: Celmer, Walter D.; Cullen, Walter P.; Shibakawa, Riichiro; Tone, Junsuke;, Assignee: Pfizer Inc. (New York, NY) |
Combination therapy using antitumor immunotoxins with tumor necrosis factor
OF THE INVENTION A. Definitions As used herein, "therapeutic" treatment refers to administration of the combination of the invention to a subject after a tumor burden has been determined in that subj... Read More
Inventors: Zimmerman, Robert;, Assignee: Cetus Corporation (Emeryville, CA) |
Method for producing a vaccine against bacterial infections caused by pseudomonas aeruginosa
What is claimed and desired to be secured by U.S. Letters Patent is: 1. Method for isolating a nontoxic, nonpyrogenic polysaccharide antigen from the crude slime of Pseudomonas aeruginosa comprising t... Read More
Inventors: Pier, Gerald B.; Sadoff, Jerald C.;, Assignee: The United States of America as represented by the Secretary of the Army (Washington, DC) |
Heterocyclic alkylaminoheterocycles
What we claim is: 1. A compound of the formula: ##STR5## wherein A taken together with the nitrogen and carbon atoms shown forms a quinazoline, thiazoline, or quinoline ring or when Het is other than ... Read More
Inventors: Durant, Graham J.; Emmett, John C.; Ganellin, Charon R.;, Assignee: SmithKline & French Laboratories Limited (Welwyn Garden City, GB2) |
Antibiotic SF-1130-x.sub.3 3 substance and production and use thereof
OF THE INVENTION According to a first aspect of this invention, therefore, there is provided SF-1130-x.sub.3 substance which is an oligosaccharide of weakly basic nature in the form of colorless powd... Read More
Inventors: Omoto, Shoji; Itoh, Jiro; Niwa, Tomizo; Shomura, Takashi; Niizato, Tetsutaro; Inouye, Shigeharu;, Assignee: Meiji Seika Kaisha, Ltd. (Tokyo, JP) |
Enzymatic degradation of lipopolysaccharide bioemulsifiers
OF THE INVENTION 6.1. Isolation of Microorganisms That Produce Lipopolysaccharide Bioemulsifier-Degrading Enzymes A wide variety of naturally occurring microorganisms, including, but not limited to b... Read More
Inventors: Shoham, Yuval; Rosenberg, Eugene; Gutnick, David L.;, Assignee: Petroleum Fermentations N.V. (Willemstad, AN) |
Bath preparation comprising fumaric acid and carbonate salt
OF THE INVENTION The carbonate which can be used in the bathing preparation of the present invention is not critical to the present invention. Examples thereof include sodium hydrogencarbonate, sodiu... Read More
Inventors: Ichii, Yuji; Sato, Hirotaka; Watanabe, Isamu; Yorozu, Hidenori;, Assignee: KAO Corporation (Tokyo, JP) |
Selective hydrogenation products of C-076 compounds and derivatives thereof
What is claimed is: 1. A compound having the formula: ##STR4## wherein R.sub.1 is iso-propyl or sec-butyl; R.sub.2 is methoxy, hydroxy or loweralkanoyloxy; and R.sub.3 is hydrogen; loweralkanoyl; .alp... Read More
Inventors: Chabala, John C.; Fisher, Michael H.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Dental implant
We claim: 1. In a dental implant having an implant portion adapted to be inserted into the bone, the improvement comprising said portion, when viewed from side to side of said implant, comprising end ... Read More
Inventors: Weiss, Charles M.; Lemons, Jack E.; Bidez, Martha W.;, Assignee: Oratronics, Inc (New York, NY); U.A.B. Research Foundation (Birmingham, AL) |
Method and composition for preventing NSAID-induced renal failure
We claim: 1. A method of preventing renal failure in a warm-blooded animal resulting from administration of a non-steroidal anti-inflammatory drug (NSAID) which comprises administering, stepwise or in... Read More
Inventors: Carini, David J.; Duncia, John J. V.; Wong, Pancras C. B.;, Assignee: E. I. Du Pont de Nemours and Company (Wilmington, DE) |
Pharmaceutical compsition of herpes simplex virus type-1 (HSV-1), glycoproteins
The purpose of this invention is to produce, by recombinant DNA techniques, HSV glycoproteins or non-glycoprotein polypeptides, including but not limited to a gD-related, gB-related or Vmw65-related p... Read More
Inventors: Ghiasi, Homayan; Nesburn, Anthony B.; Wechsler, Steven L.;, Assignee: Cedars-Sinai Medical Center (Los Angeles, CA) |
Biphenyl derivatives
We claim: 1. A diastereoisomer or optically active antipode of a compound of the formula ##STR5## wherein R.sub.3 is (alkoxy of 1 to 6 carbon atoms)-carbonyl. 2. A compound of claim 1, which is methyl... Read More
Inventors: Nickl, Josef; Muller, Erich; Narr, Berthold; Haarmann, Walter; Schroter, Wolfgang; Kadatz, Rudolf;, Assignee: Boehringer Ingelheim GmbH (Ingelheim am Rhein, DE) |
Fluoralkylatedcarbapenem derivatives
We claims: 1. A compound of the formula ##STR37## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is a substituent of the formula ##STR38## wherein R.sub.4, R.sub.5 and R.sub.6 are the same or diff... Read More
Inventors: Mak, Ching P.; Fliri, Hans;, Assignee: Sandoz Ltd. (Tokyo, JP) |
Testosterone derivatives
OF THE INVENTION EXAMPLE 1 Testosterone Methyl Ether ##SPC3## A solution of 50 g. of testosterone in 500 ml. of dimethylformamide was cooled to 5.degree. C in an ice bath and 58 g. of silver oxide an... Read More
Inventors: Babcock, John C.; Campbell, J. Allan;, Assignee: The Upjohn Company (Kalamazoo, MI) |
Method of treating arthritic disease
OF THE INVENTION The active compounds of the present invention are obtainable as crystalline materials having characteristic melting points and absorption spectra. They are appreciably soluble in man... Read More
Inventors: Tomcufcik, Andrew S.; Sloboda, Adolph E.;, Assignee: American Cyanamid Company (Stamford, CT) |
Therapeutic agents containing tamoxifen and salts thereof
What is claimed is: 1. A method for the treatment of psoriasis in a warm-blooded animal requiring such treatment which comprises administering to said animal an effective amount of therapeutic agent s... Read More
Inventors: Kraus, Hans A.;, Assignee: Imperial Chemical Industries plc (London, GB2) |
Lactams, their synthesis and use in cosmetic compositions
I claim: 1. A process for the synthesis of a lactam which comprises the steps of treating an esterified deoxyamino uronic acid with a base to yield a lactam and recovering same, said lactam having the... Read More
Inventors: Gibson, Walter T.;, Assignee: Unilever Patent Holdings B.V. (Rotterdam, NL) |
Method of growing hair
We claim: 1. A method for inducing, maintaining or increasing hair growth which comprises topically applying a preserved composition to mammalian skin and hair, in a mammal having need thereof, said c... Read More
Inventors: Davis, Michael F. A.; Gibson, Walter T.;, Assignee: Chesebrough-Pond's USA Co., division of Conopco, Inc. (Greenwich, CT) |
Viscoelastic dentifrice composition
We claim: 1. A linear viscoelastic dentifrice composition in the form of a toothpaste or dental gel with a pH of about 4 to about 9 comprising an orally acceptable water/humectant vehicle, an orally a... Read More
Inventors: Prencipe, Michael; Durga, Gary A.;, Assignee: Colgate Palmolive Company (Piscataway, NJ) |
Renin inhibitors having all retro-inverted peptide bonds
We claim: 1. A peptide of the formula I ##STR246## or salt thereof in which X represents a group of the formula ##STR247## or represents hydroxyl, alkoxy having up to 4 carbon atoms, benzyloxy or a gr... Read More
Inventors: Bender, Wolfgang; Kinast, Gunther; Knorr, Andreas; Stasch, Johannes-Peter;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
Substituted pyridine-2,4-dicarboxylic acid compounds and methods of use thereof
We claim: 1. A substituted pyridine-2,4-dicarboxylic acid derivative of the formula I ##STR36## in which: R.sup.1 denotes alkyl, alkenyl or alkynyl with up to 9 C atoms, the radicals mentioned being o... Read More
Inventors: Baader, Ekkehard; Bickel, Martin; Brocks, Dietrich; Gunzler, Volkmar; Henke, Stephan; Hanauske-Abel, Hartmut;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Thiohydantoin inhibitors of collagen-induced and ADP-induced platelet aggregation
OF THE INVENTION As used herein, the expressions "alkyl", "alkenyl", "alkynyl" and "alkyloxy" are defined to include straight or branched carbon-carbon linkages of 1 to 5 carbon atoms. The term "phar... Read More
Inventors: Baran, John S.; Lindberg, Tom; Mazur, Robert H.; Moorman, Alan E.; Steinman, Doug;, Assignee: G. D. Searle & Co. (Chicago, IL) |
Arginine compounds as ocular hypotensive agents
The present invention addresses one or more of the foregoing problems encountered in controlling ocular hypertension. The invention is concerned with agents that are effective and nontoxic, identified... Read More
Inventors: Varma, Rajender S.; Chiou, George C. Y.;, Assignee: Baylor College of Medicine (Houston, TX) |
Method of isolating restriction fragment deletions in vibrio cholerae and products thereof
OF THE INVENTION The principle of the present invention is the isolation of a Vibrio cholerae vaccine strain specifically altered through recombinant DNA technology to render it avirulent without aff... Read More
Inventors: Kaper, James B.; Levine, Myron M.;, Assignee: Swiss Serum and Vaccine Institute Berne (Berne, CH) |
Protein having cell growth stimulating action, composition thereof and method for producing the same
What is claimed is: 1. A protein having cell growth stimulating activity, said protein selected from those obtained from a culture of a microorganism selected from the group consisting of Staphylococc... Read More
Inventors: Fujii, Setsuro; Chikazawa, Nobumoto; Arima, Teruo; Fukushima, Masakazu;, Assignee: Sanwa Kagaku Kenyusho Co., Ltd. (Nagoya, JP) |
Density element for ruminal delivery device
We claim: 1. A density element for use in a ruminal drug delivery device comprising an agglomeration of high density particles bonded together, said density element having: a) a density of at least 2.... Read More
Inventors: Peery, John R.; Eckenhoff, James B.;, Assignee: Alza Corporation (Palo Alto, CA) |
Aerosol anesthetic compositions
OF THE INVENTION This invention relates to liquid anesthetic compositions in aerosol containers comprising a single phase mixture of a water washable base of benzocaine in a solvent and a propellant.... Read More
Inventors: Lin, Song-Ling; Park, Moo-Kwang;, Assignee: American Home Products Corporation (New York, NY) |
Cyclohexane derivatives
OF THE INVENTION: This invention relates to novel compounds of cyclohexane derivatives, to a process for the preparation these compounds and their uses as selective herbicides. In particularly this i... Read More
Inventors: Sawaki, Mikio; Iwataki, Isao; Hirono, Yoshihiko; Ishikawa, Hisao;, Assignee: Nippon Soda Company, Ltd. (Tokyo, JA) |
Vasodialators 
