Polyhalobenzylic disulfooxonium compounds
What is claimed is: 1. A compound of the formula: ##STR86## wherein Hal is a halogen selected from the group consisting of fluorine, chlorine, bromine and iodine; X is a substituent selected from the ... Read More
Inventors: Mark, Victor; Zengierski, Leon R.;, Assignee: Hooker Chemicals & Plastics Corporation (Niagara Falls, NY) |
3-(P-methoxybenzylthio)2-non-oxocarbonylic pyridines
What is claimed is: 1. A compound of the formula: ##SPC5## in which R' is carboxy, COO-lower alkyl or CONH.sub.2.
Description:
This invention relates to a new process of preparing 3-thio... Read More
Inventors: Blank, Benjamin; Gleason, John G.;, Assignee: SmithKline Corporation (Philadelphia, PA) |
Synthesis of 1-substituted isoquinolines
OF THE INVENTION The present invention may be appreciated by reference to the following Reaction Scheme 1: ##STR2## The compound of formula (I) has a double bond between the isoquinoline and benzyl g... Read More
Inventors: Hendrickson, James B.; Rodriguez, Cesar;, Assignee: |
Sulfur-containing bis-imino carbamate compounds, pesticidal composition and use
What is claimed is: 1. A compound of the formula: ##STR23## wherein: n=1 or 2; R, R', R.sub.1, R.sub.2, and R.sub.3 are individually alkyl groups of one to four carbon atoms; R.sub.4 is: piperidino, p... Read More
Inventors: D'Silva, Themistocles D. J.;, Assignee: Union Carbide Corporation (Danbury, CT) |
Dental cream composition
I claim: 1. A dental cream consisting essentially of a vehicle of water and humectant and a gelling agent, from 20 to 75% by weight of a polishing material wherein at least about 95% by weight of said... Read More
Inventors: Barberio, Giacinto G.;, Assignee: |
Intracellular trapping of therapeutics or tracer agents
OF THE INVENTION The present invention basically involves attaching primary amine-containing therapeutic and/or tracer agents to cellobiose to form an intracellularly trappable nonmetabolizable adduc... Read More
Inventors: Pittman, Ray C.;, Assignee: University of California (Berkeley, CA) |
Metallo-substituted naphthalene
It is claimed: 1. Compounds of the formula ##STR4## wherein R is lower alkyl and R.sub.1 and R.sub.2 are lower alkyl, or aralkyl of 7 to about 12 carbon atoms, and M is MgBr. 2. The compounds of claim... Read More
Inventors: Rapoport, Henry; Snyder, Clinton D.;, Assignee: The Regents of the University of California (Berkeley, CA) |
Stabilized pharmaceutical composition and method of producing same
OF THE INVENTION ATP-2Na, which is to be used in the practice of the invention, has the following structure: ##STR1## The main reaction involved in the decomposition of this substance is said to be h... Read More
Inventors: Makino, Tadashi; Doi, Koji;, Assignee: Senju Pharmaceutical Co., Ltd. (Osaka, JP) |
Cephalosporins
What is claimed is: 1. A cephalosporin represented by the following formula or a salt thereof: ##STR557## wherein R.sup.1 represents a hydrogen atom or a carboxyl-protecting group; R.sup.2 represents ... Read More
Inventors: Sadaki, Hiroshi; Narita, Hirokazu; Imaizumi, Hiroyuki; Konishi, Yoshinori; Inaba, Takihiro; Hirakawa, Tatsuo; Taki, Hideo; Tai, Masaru; Watanabe, Yasuo; Saikawa, Isamu;, Assignee: Toyama Chemical Co., Ltd. (Tokyo, JP) |
Bis-(aryloxycarboxylic acid) compounds
We claim: 1. A compound of the formula ##STR5## or a pharmaceutically acceptable salt thereof. 2. A compound of the formula ##STR6## or a pharmaceutically acceptable salt thereof.
Descriptio... Read More
Inventors: Cognacq, Jean C.; Lacrampe, Jean;, Assignee: Hexachimie (FR) |
Ester substituted dibiguanides and non-toxic antimicrobial compositions thereof
I claim: 1. A dibiguanide compound free of toxic substances having the structural formula: ##STR7## wherein one of A and B is hydrogen and the other is the ester radical ##STR8## and R is an alkyl gro... Read More
Inventors: Bauman, Robert Andrew;, Assignee: Colgate Palmolive Company (New York, NY) |
Protein binding method
I claim: 1. In a method for determining the concentration of an analyte in a sample wherein the sample is extracted with a substantially water immiscible organic solvent, the solvent removed from the ... Read More
Inventors: Groman, Ernest V.;, Assignee: Baxter Travenol Laboratories, Inc. (Deerfield, IL) |
Method of treating psoriasis of the nails and composition
OF THE PREFERRED EMBODIMENTS In the practice of the present invention, topical steroids such as betamethhasone valerate is sold under the trademark Valisone.RTM. by Schering Corporation, Galloping Hi... Read More
Inventors: Bernstein, Joel E.;, Assignee: |
Film forming composition and uses thereof
We claim: 1. A non-gelling, film-forming composition comprising a stable aqueous solution containing 25% to 40% by weight of partially hydrolysed collagen protein solids having a molecular weight of f... Read More
Inventors: Easton, Ian A.; Glen, James M.; Kieran, Ann G.;, Assignee: Devro, Inc. (Somerville, NJ) |
Useful pro-drug forms of theophylline
OF THE INVENTION Preparation of the compounds of formula (i): using stoichiometric amounts of each reactant, the compounds encompassed within Formula (I) can be prepared by any one of methods "A" thr... Read More
Inventors: Higuchi, Takeru; Bodor, Nicolae S.; Kuo, Yu-Neng;, Assignee: Interx Research Corporation (Lawrence, KS) |
N-(1-substituted-3-pyrrolidinyl)-4-quinolinecarboxamides
OF INVENTION The novel compounds of the invention having the foregoing Formula I are generally characterized by important pharmacological activity and are effective as anti-emetic agents and, as such... Read More
Inventors: Cale, Jr., Albert Duncan;, Assignee: A. H. Robins Company, Incorporated (Richmond, VA) |
Feed compositions containing copper salts of 2-hydroxypyridine-N-oxides
What is claimed is: 1. The method of improving the weight gain and feed efficiency of meat-producing monogastric animals comprising feeding to said animals an effective but nontoxic quantity of a comp... Read More
Inventors: Menon, Govind K.; Sanders, Winfred J.;, Assignee: SmithKline Beckman Corporation (Philadelphia, PA) |
Certain naphthalenyl imidazo compounds and their pharmaceutical use
AND PREFERRED EMBODIMENT The Formulae I and Ia are recognized as being tautomeric structures of one another. The imidazo compounds having the hydrogen atom on one of the imidazo nitrogen atoms (e.g.,... Read More
Inventors: Robertson, David W.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Method of treating patients suffering from chronic pain or chronic cough
OF THE INVENTION The present invention relates to methods of treating a patient in chronic pain or with chronic cough over a prolonged period to provide systemic analgesia or central antitussive effe... Read More
Inventors: Kreek, Mary J.; Fishman, Jack;, Assignee: The Rockefeller University (New York, NY) |
Cerebral vasodilating 20,21-dinoreburnamenine derivatives
OF THE INVENTION Within the compounds of formula I, the hydroxyl and the hydrogen in the 14-position of the molecule each can take either of the two possible positions around the carbon atom to which... Read More
Inventors: Farcilli, Andre; Medici, Italo; Fournex, Robert; Barzaghi, Fernando;, Assignee: Roussel Uclaf (Romainville, FR) |
Piperazinyl-imidazo[1,2-a]pyrazines
OF THE INVENTION The novel and pharmaceutically valuable compound of this invention has the structural formula: ##STR1## or pharmaceutically acceptable salt thereof, wherein: the piperazinyl group ##... Read More
Inventors: Lumma, William C.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
High conversion of C.sub.3 and C.sub.4 olefins to corresponding unsaturated aldehydes and acids with stable molybdenum catalysts
Preparation of the Precursor The precursors employed in preparing the final catalysts of the present invention are prepared employing the chloride ion stabilization step as described in aforesaid par... Read More
Inventors: Daniel, Chelliah;, Assignee: Air Products and Chemicals, Inc. (Allentown, PA) |
6-Halo-5-cyclohexylindan-1-carbohydroxamic acid
We claim: 1. A compound of the formula ##STR19## wherein X represents halogen. 2. The compound as claimed in claim 1, wherein X is chlorine.
Description:
This invention relates to novel ... Read More
Inventors: Noguchi, Shunsaku; Araki, Yoshiaki; Imanishi, Masayuki; Kawai, Kiyohisa;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JA) |
Substituted sulfonimidamides, processes for their preparation, their use as a medicament or diagnostic, and medicament comprising them
What is claimed is: 1. A sulfonimidamide of the formula I ##STR12## in which: at least one of the three substituents R(1 ), R(2) and R(3) is a benzoylguanidine ##STR13## which is unsubstituted or subs... Read More
Inventors: Kleemann, Heinz-Werner; Brendel, Joachim; Schwark, Jan-Robert; Weichert, Andreas; Lang, Hans Jochen; Albus, Udo; Scholz, Wolfgang;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Phototherapy using methylene blue
OF THE INVENTION The thiazine dye methylene blue plus light has been shown to hydroxylate both guanosine and deoxyguanosine to yield 8-OH-guanosine (8-OH-G) and 8-OH-deoxyguanosine (8-OH-dG), respect... Read More
Inventors: Floyd, Robert A.;, Assignee: Oklahoma Medical Research Foundation (Oklahoma City, OK) |
Quinolonecarboxylic acid derivatives and pharmaceutical preparations thereof for treatment of an allergic disease of the respiratory tract
What is claimed is: 1. A quinolone compound of the formula ##STR10## wherein m and n independently are each 1-4; R.sub.1 is hydrogen or alkyl of 1-6 carbon atoms; R.sub.2 is hydrogen, alkanoyl of 1-8 ... Read More
Inventors: Albrecht, Rudolf; Schroder, Eberhard; Bottcher, Irmgard;, Assignee: Schering, Aktiengesellschaft (Berlin and Bergkamen, DE) |
1-alkyl-2-aminotetralin derivatives
We claim: 1. A compound of the formula ##STR32## wherein R.sup.3 the NR.sup.1 R.sup.2 group are in a cis-position to each other and wherein Y is in position 5 and is OH, or R.sup.6 O, whereby and R.su... Read More
Inventors: Arvidsson, Folke L. E.; Carlsson, Per A. E.; Hacksell, Uli A.; Hjorth, John S. M.; Johansson, Anette M.; Lindberg, Per L.;, Assignee: Per Arvid Emil Carlsson (Gothenburg, SE) |
Process and intermediates for preparing compounds having a disubstituted acetylene moiety and retinoic acid-like biological activity
What is claimed is: 1. Compounds of the formula ##STR11## wherein: X is NR' where R' is hydrogen or lower alkyl and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are hydrogen or lower alkyl having 1 ... Read More
Inventors: Chandraratna, Roshantha A. S.;, Assignee: Allergan, Inc. (Irvine, CA) |
Methods for lowering serum cholesterol
This invention provides new methods for lowering serum cholesterol levels, comprising administering a compound of formula (I): ##STR3## wherein: R.sup.1 and R.sup.2 are, independently, --H, --OH, halo... Read More
Inventors: Bryant, Henry U.; Grese, Timothy A.;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
3-(4-Piperidyl)-1,2-benzisoxales
We claim: 1. A compound of the formula ##STR13## wherein R is hydrogen, loweralkyl, loweralkenyl, cycloalkylloweralkyl, phenyloweralkyl, hydroxy, diloweralkylaminoloweralkyl, cyano, cyanomethyl, ##STR... Read More
Inventors: Strupczewski, Joseph T.; Gardner, Beth Ann; Allen, Richard C.;, Assignee: Hoechst-Roussel Pharmaceuticals (Somerville, NJ) |
Vasodialators 
