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| Latest patents |
Results: 991-1020 of 1119
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3-(4-Piperidinyl)-1,2-benzisothiazoles
I claim: 1. A compound of the formula ##STR34## wherein R is hydrogen, loweralkyl, loweralkenyl, cycloalkylloweralkyl, phenylloweralkyl, hydroxy, diloweralkyaminoloweralkyl, cyano, cyanomethyl, ##STR3... Read More
Inventors: Strupczewski, Joseph T.;, Assignee: Hoechst-Roussel Pharmaceuticals (Somerville, NJ) |
Antipsychotic 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles
I claim: 1. A compound of the formula ##STR84## wherein R is hydrogen, loweralkyl, loweralkenyl, lowercycloalkylloweralkyl, ##STR85## cyano, cyanomethyl, formyl, loweralkanoyl, diloweralkylphosphinome... Read More
Inventors: Strupczewski, Joseph T.;, Assignee: Hoechst-Roussel Pharmaceuticals Inc. (Somerville, NJ) |
Imide derivatives and their pharmaceutical use
What is claimed is: 1. A compound of the formula: wherein A is a carbonyl group or a sulfonyl group; B is either one of the formulas: ##STR102## (in which R.sub.1 and R.sub.2 are each a hydrogen atom,... Read More
Inventors: Antoku, Fujio; Yoshigi, Mayumi; Saji, Ikutaro; Ishizumi, Kikuo;, Assignee: Sumitomo Pharmaceuticals Company, Limited (Osaka, JP) |
Psychotropic benzisothiazole derivatives
We claim: 1. The compounds of formula (I) ##STR7## wherein R.sup.1 is hydrogen, hydroxy, cyano, alkyl of 1 to 3 carbon atoms, alkoxy of 1 to 3 carbon atoms, halo or trifluoromethyl; (O) represents opt... Read More
Inventors: Stack, Gary P.; Abou-Gharbia, Magid A.; Golobish, Thomas D.;, Assignee: American Home Products Corporation (New York, NY) |
Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics
OF THE PREFERRED EMBODIMENT The compounds of this invention are useful as antipsychotic drugs and as analgesic agents. The compounds of the invention can contain a variety of different substituents a... Read More
Inventors: Strupczewski, Joseph T.; Helsley, Grover C.; Chiang, Yulin; Bordeau, Kenneth J.; Glamkowski, Edward J.;, Assignee: Hoechst-Roussel Pharmaceuticals, Inc. (Somerville, NJ) |
Substituted 1H-indazole-3-carboxamides
We claim: 1. Compounds of formula 1: ##STR14## wherein R.sub.1 is straight or branched alkyl having 1-4 C-atoms, halogen or cyano; n has the value 0-1; R.sub.2 is hydrogen, (1-6 C)alkyl, (3-6 C)alkeny... Read More
Inventors: Hamminga, Derk; van Wijngaarden, Ineke;, Assignee: Duphar International Research B.V. (Weesp, NL) |
Imidazole and benzimidazole derivatives
OF THE INVENTION In its broadest aspects the present invention relates to the compounds of formula I and to pharmaceutical compositions and methods employing such compounds. The term "aryl", as used ... Read More
Inventors: Poss, Michael A.;, Assignee: E.R. Squibb & Sons, Inc. (Princeton, NJ) |
Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity
We claim: 1. Compounds of general formula ##STR7## wherein R represents hydrogen, (C.sub.1-6)alkyl, cyclopentyl, cyclohexyl, or cycloheptyl; R.sub.1 and R.sub.2 independently represent hydrogen, halog... Read More
Inventors: Alberto, Sala; Benedini, Francesca; Cereda, Roberta; Del Soldato, Piero;, Assignee: Italfarmaco S.P.A. (Milan, IT) |
GABA and L-glutamic acid analogs for antiseizure treatment
OF THE INVENTION In accordance with the present invention, there is provided a series of 3-alkyl-4-aminobutyric acid or 3-alkyl glutamic acid analogs which are useful as anticonvulsants. Illustrative... Read More
Inventors: Silverman, Richard B.; Andruszkiewicz, Ryszard; Yuen, Po-Wai;, Assignee: Northwestern University (Evanston, IL); Warner-Lambert Company (Ann Arbor, MI) |
Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension
What is claimed is: 1. A therapeutic method for treating hypertension, said method comprising administering to a hypertensive patient a therapeutically-effective amount of a compound of Formula I: ##S... Read More
Inventors: Hanson, Gunnar J.;, Assignee: G. D. Searle & Co. (Chicago, IL) |
Process for the preparation of O-substituted derivatives of (+)-cyanidan-3-01
We claim: 1. A process for the preparation of a (+)-cyanidan-3-ol compound of the formula ##STR4## in which R.sub.1 O represents a protected hydroxy group which is readily hydrolyzed or hydrogenated a... Read More
Inventors: Albert, Alban; Courbat, Pierre; Weith, Andre;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Insecticidal product and preparation thereof
What is claimed is: 1. The enantiomeric pair of isomers represented by (S)-.alpha.-cyano-3-phenoxybenzyl 1R,cis-3-(Z-2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethylcyclopropa ne carboxylate and (... Read More
Inventors: Robson, Michael J.;, Assignee: Imperial Chemical Industries PLC (London, GB2) |
Phenoxy unsaturated carboxylic acid esters and derivatives
What is claimed is: 1. A compound of the formula ##STR26## wherein W is oxygen, R.sup.1 is hydrogen or lower alkyl and each of X and Y is independently selected from hydrogen, bromo, chloro, fluoro, l... Read More
Inventors: Lee, Shy-Fuh;, Assignee: Zoecon Corporation (Palo Alto, CA) |
Furo 3,2-c pyridine derivatives and their use in treating depression and cerebral ischemia
We claim: 1. A compound of the formula ##STR5## wherein R.sub.1 represents a phenyl, halophenyl, methylphenyl, ethylphenyl, methoxyphenyl, trifluoromethylphenyl or naphthyl group, and R.sub.2 represen... Read More
Inventors: Wick, Alexander; Frost, Jonathan; Bertin, Jean;, Assignee: Synthelabo (Paris, FR) |
4-Substituted-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
About 70% of all renal calculi contain oxalate as the main component of the matrix. In the majority of patients the condition is associated with a higher than average level of metabolically produced ... Read More
Inventors: Cragoe, Jr., Edward J.; Rooney, Clarence S.; Williams, Haydn W. R.;, Assignee: Merck & Co., Inc. (Rahway, NJ); Merck Sharp & Dohme (I.A.) Corp. (Rahway, NJ) |
Treatment for osteoporosis
What is claimed is: 1. A method for prevention or treatment of osteoporosis, which comprises administering to a patient in need of such prevention or treatment, as an active ingredient, an effective a... Read More
Inventors: Tsuda, Masao; Sawa, Yoichi; Yamazaki, Iwao;, Assignee: Takeda Chemical Industries, Ltd. (Osaka, JP) |
Acetylene amines and their use as vasodilators and antihypertensives
OF THE INVENTION Compounds of the invention are of the following formula ##STR3## wherein Y is independently alkyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, alkanoyloxy, alkanoylamino, amino,... Read More
Inventors: Carson, John R.;, Assignee: McNeilab, Inc. (Fort Washington, PA) |
Immunostimulant medicine
What is claimed is: 1. A process for stimulating the immunity of a living organism comprising orally or subcutaneously administering to said organism in an amount effective to stimulate immunity an im... Read More
Inventors: Renoux, Gerard E.; Renoux, Micheline;, Assignee: Institut Merieux (FR) |
5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use
OF THE INVENTION In the compounds of the Formula I, the term lower alkyl of from one to six carbons, inclusive, means a straight or branched alkyl group, such as, for example, methyl, ethyl, propyl, ... Read More
Inventors: Hamilton, Harriet W.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Process for the producing .epsilon.-caprolactam from the distillation of cyclohexanone oxime
What we claim is: 1. A process for utilizing the dark brown to black residue which is obtained in the distillation recovery of pure cyclohexanone oxime which comprises introducing cyclohexanone oxime ... Read More
Inventors: Immel, Otto; DE Jager, Andre; Kaiser, Bernd-Ulrich; Schwarz, Hans-Helmut; Starke, Klaus;, Assignee: Bayer Aktiengesellschaft (DE) |
Water-soluble azo dyestuffs containing triazine and 3-azo-2,6-dihydroxypyrid-6-one radicals
We claim: 1. A monoazo dyestuff of the formula ##SPC11## wherein n is 1 or 2; Y is selected from the group consisting of hydrogen, lower alkyl and CONH.sub.2 ; and X is a cellulose reactive group sele... Read More
Inventors: Berrie, Alistair Howard; Budziarek, Richard;, Assignee: Imperial Chemical Industries Limited (London, EN) |
Keratin fiber dye compounds
What is claimed is: 1. A compound of the formula ##SPC10## wherein R is selected from the group consisting of -alkylaminodialkyl, -alkylmorpholino and -alkylpiperidino and X represents halogen, the al... Read More
Inventors: Kalopissis, Gregoire; Bugaut, Andree; Zorayan, Vahan;, Assignee: L'Oreal (Paris, FR) |
Homoserine derivatives and their use as microbicides
What is claimed is: 1. A homoserine derivative of the formula I ##STR49## wherein R.sub.1 is alkyl of 2 to 6 carbon atoms wich is optionally interrupted by an oxygen or a sulfur atom, 2-furyl, 2-tetra... Read More
Inventors: Kunz, Walter; Eckhardt, Wolfgang; Hubele, Adolf; Riebli, Peter;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Allophanate derivative, fungicidal compositions and use
What is claimed is: 1. An allophanate derivative of the formula ##STR117## in which R.sup.1 represents C.sub.5 -C.sub.10 -cycloalkyl, optionally substituted by C.sub.1 -C.sub.6 -alkyl, or represents C... Read More
Inventors: Fuhrer, Wolfgang; Kuhle, Engelbert; Hanssler, Gerd;, Assignee: Bayer Aktiengesellschaft (Leverkusen, DE) |
N-phenyl-n-alkoxycarbonylalkyl glycinamides, their preparation and the medicaments containing them
What is claimed is: 1. Compounds of formula: ##STR9## in which R.sub.1 represents a hydrogen atom or an alkyl or alkoxycarbonyl group or a phenyl group which is unsubstituted or substituted by at leas... Read More
Inventors: Bourzat, Jean-Dominique; Capet, Marc; Cotrel, Claude; Guyon, Claude; Manfre, Franco; Roussel, Gerard;, Assignee: Rhone-Poulenc Rorer, S.A. (FR) |
Pharmaceutical composition containing 5:6-benzo-alpha-pyrone derivatives and method of use thereof
We claim: 1. A pharmaceutical composition suitable for the treatment of allergies, said composition in the form of a tablet, pill, capsule, cream or paste which comprises a suitable carrier for oral o... Read More
Inventors: Doria, Gianfederico; Giraldi, Pier Nicola; Lauria, Francesco; Corno, Maria Luisa; Sberze, Piero; Tibolla, Marcello;, Assignee: Carlo Erba, S.p.A. (Milan, IT) |
Compositions and methods for cleaning the gums
OF THE INVENTION The silicas that may be used in the composition of the present invention are those silicas that are capable of functioning as thickening agents without causing the composition to hav... Read More
Inventors: Ladas, Athanasios S.; Burnett-Davis, Debbie L.; Sharpe, Ronald J.; Ispentchian, Suzanne H.;, Assignee: Pfizer Inc. (New York, NY) |
Aerosol hair spray composition
OF THE INVENTION The resin employed in this invention is a copolymer of a lower alkyl ester, i.e., a one to four carbon atom alkyl ester, of alkyl vinyl ether-maleic acid copolymer. The copolymer thu... Read More
Inventors: Benson, Alice B.; Hourihan, Joseph C.; Tripathi, Uma;, Assignee: Playtex Beauty Care, Inc. (Stamford, CT) |
Dentifrice compositions
OF THE INVENTION By "safe and effective amount," as used herein, means a sufficient amount to reduce stain and/or plaque/gingivitis without harming the tissues and structures of the oral cavity. By t... Read More
Inventors: Rice, David E.;, Assignee: The Proctor & Gamble Company (Mason, OH) |
Stable high internal phase ratio topical emulsions
I claim: 1. Delivery systems for topical preparations which comprise nonlipoidal media in lipoidal media emulsions in which the nonlipoidal phase is at least 75% of the emulsion, the lipoidal phase co... Read More
Inventors: Cuca, Robert C.;, Assignee: K-V Pharmaceutical Company (St. Louis, MO) |
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Vasodialators 
