|
| Latest patents |
Results: 121-150 of 1119
|
Substituted derivatives of 2-azabicyclo-[3.3.0]octanes
We claim: 1. A compound of the formula I ##STR140## in which n is a whole number between 0 and 3 inclusive; R.sup.1 and R.sup.1', being the same or different, are hydrogen; alkyl or alkenyl having 1-8... Read More
Inventors: Henning, Rainer; Urbach, Hansjorg; Geiger, Rolf; Teetz, Volker; Scholkens, Bernward;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
N-(3,3-diphenylpropyl) aminoethyl esters of 1,4-dihydro-2,6-dimethyl-pyridine-3,5-dicarboxylic acid, compositions and use
OF THE INVENTION More particularly according to the present invention, it will be appreciated that a variety of syntheses are encompassed within the metes and bounds of the process hereinbefore outli... Read More
Inventors: Nardi, Dante; Leonardi, Amedeo; Graziani, Gabriele; Bianchi, Giorgio;, Assignee: Recordati S.A., Chemical and Pharmaceutical Company (Chiasso, CH) |
Pharmaceutical composition for the treatment of high blood pressure
We claim: 1. A pharmaceutical composition containing a synergistically effective amount of: (a) an angiotensin converting enzyme inhibitor, or its physiologically tolerated salt, of formula (III): ##S... Read More
Inventors: Becker, Reinhard; Geiger, Rolf; Henning, Rainer; Teetz, Volker; Urbach, Hansjorg;, Assignee: Hoechst Aktiengesellschaft (Frankfurt am Main, DE) |
Method of treating epithelial disorders
We claim: 1. A method of treating subjects suffering from psoriasis which comprises the systemic administration to said subjects of an effective amount of a compound of formula ##STR26## a pharmaceuti... Read More
Inventors: Van Wauwe, Jean P. F.; Raeymaekers, Alfons H. M.;, Assignee: Janssen Pharmaceutica, N.V. (Beerse, BE) |
Process for preparing carboline derivatives
OF THE INVENTION In accordance with the process of this invention, substantially equimolar amounts of the unsubstituted amine starting material, the acetylenic reagent and formaldehyde are employed i... Read More
Inventors: Welch, Jr., Willard M.;, Assignee: Pfizer Inc. (New York, NY) |
Imidazodiazepine derivatives
What is claimed: 1. A compound of the formula ##STR31## wherein A together with the two carbon atoms denoted as .alpha. and .beta. is selected from the group consisting of ##STR32## the dotted line re... Read More
Inventors: Gerecke, Max; Haefely, Willy; Hunkeler, Walter; Kyburz, Emilio; Mohler, Hanns; Pieri, Lorenzo; Polc, Petar;, Assignee: Hoffman-La Roche Inc. (Nutley, NJ) |
Process for making epsilon-caprolactam
We claim: 1. A process for manufacturing epsilon-caprolactam comprising passing cyclohexanone oxime over a zeolite having a silica to alumina ratio of at least 12 and a Constraint Index of 1 to 12. 2.... Read More
Inventors: Bell, Weldon K.; Chang, Clarence D.;, Assignee: Mobil Oil Corporation (New York, NY) |
1,4-Substituted piperazinyl derivatives useful as psychostimulants
What is claimed is: 1. A compound of formula I, ##STR17## wherein each of R.sub.1 and R.sub.4, which may be the same or different, is hydrogen, halogen of atomic number from 9 to 35, alkyl of 1 to 4 c... Read More
Inventors: Bastian, Jean-Michel;, Assignee: Sandoz Ltd. (Basel, CH) |
Process for the preparation of tablets with retarded liberation of the active agent is predetermined
What we claim is: 1. Process for the preparation of controlled release tablets containing an active agent comprising: (a) granulating the active agent with an organic solvent solution or a water dispe... Read More
Inventors: Sothmann, Gunnar A.; Marttila, Esko V.;, Assignee: Orion-yhtyma Oy (FI) |
Method for the preparation of granulates suited for the production of sustained release coated tablets for oral use
What is claimed is: 1. A process for the preparation of tablets slowly releasing an active principle which consists essentially of preparing a mixture containing said active principle, a slightly swel... Read More
Inventors: Fontanelli, Luciano;, Assignee: Istituto Gentili S.p.A. (Pisa, IT) |
Erythromycin microencapsulated granules
OF THE INVENTION The invention relates to pharmaceutically active microencapsulated granules comprising erythromycin and a binder. Such erythromycin granules are particularly useful in flowable mater... Read More
Inventors: Giannini, Robert P.; Fromm, Susan M.; Suarez, Jose;, Assignee: hiMedics, Inc. (Hollywood, FL) |
Pharmaceutical preparation
We claim: 1. Controlled release preparation comprising a plurality of beads having a soluble component comprising at least 95% weight/weight of a salt of metoprolol which has a solubility of less than... Read More
Inventors: Jonsson, Ulf E.; Sandberg, John A.; Sjogren, John A.;, Assignee: Aktiebolaget Hassle (Molndal, SE) |
Mold apparatus having an outwardly angled seal for encapsulating a glass sheet
The present invention concerns an improved mold apparatus and method for at least partially encapsulating a sheet by forming a window assembly comprising a gasket and a sheet. The present invention ma... Read More
Inventors: Garza, Luis A. A. M.;, Assignee: Vidrio Plano de Mexico, S.A. (MX) |
4,5,6,7-Tetrahydro-thieno[3,2-c]-pyridine derivatives and process for their preparation
Having now described our invention what we claim as new and desire to secure by Letters Patent is: 1. A compound selected from the group consisting of 4,5,6,7-tetrahydro-thieno[3,2-c]-pyridine derivat... Read More
Inventors: Heymes, Alain; Maffrand, Jean-Pierre;, Assignee: Parcor (Paris, FR) |
Process for dimerization, arylation and trifluoromethylation of aromatic and heterocyclic compounds
OF THE INVENTION It has been found in accordance with this invention that aromatic and heterocyclic compounds can be arylated and trifluoromethylated in a convenient manner by thermally decarboxylati... Read More
Inventors: Fields, Ellis K.;, Assignee: Standard Oil Company (Indiana) (Chicago, IL) |
Mercaptoacyldihydropyrazole carboxylic acid derivatives
OF THE INVENTION The compounds of formula I are useful as hypotensive agents. They inhibit the conversion of the decapeptide angiotensin I to angiotensin II and, therefore, are useful in reducing or ... Read More
Inventors: Rovnyak, George C.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Process for preparation 4,5,6,7-tetrahydro-7-oxobenzo-[b]-thiophenes and 1,2,3,4-tetrahydro-4-oxo-1-naphthalenes
I claim: 1. A process for the preparation of a compound of the formula: ##STR13## wherein R.sub.1 and R.sub.2 are each a substituent selected from the group consisting of alkanoyl C.sub.1 -C.sub.7, ha... Read More
Inventors: Strong, Henry L.;, Assignee: American Cyanamid Company (Stamford, CT) |
4-(Substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-dione inhibitors of glycolic acid oxidase
About 70% of all renal calculi contain oxalate as the main component of the matrix. In the majority of patients the condition is associated with a higher than average level of metabolically produced ... Read More
Inventors: Cragoe, Jr., Edward J.; Rooney, Clarence S.; Williams, Haydn W. R.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Method for producing 1-nitroanthraquinone
What is claimed is: 1. A method for producing 1-nitroanthraquinone by nitration of anthraquinone, which comprises reacting anthraquinone at a temperature of 30.degree. to 80.degree. C. with a mixed ac... Read More
Inventors: Fukasawa, Akira; Masaki, Shinzaburo; Serizawa, Norio;, Assignee: Sumitomo Chemical Company, Limited (Osaka, JP) |
N-pyrazinecarbonyl-N'-acylguanidines
What is claimed is: 1. A compound of the formula: ##STR3## wherein R.sup.1 is hydrogen or lower alkyl having 1 to 5 carbon atoms; R.sup.2 is methyl or halogen; R.sup.3 is hydrogen, methyl or halogen; ... Read More
Inventors: Cragoe, Jr., Edward J.; Woltersdorf, Jr., Otto W.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Novel analogs of prostaglandins with 4-oxo-thiazolidinyl nucleus and method of preparation thereof
What is claimed is: 1. The compound of the formula ##STR41## wherein R is carboxy, a carboxy salt, or derivatized carboxy; A is selected from the group consisting of methylene and oxygen; Y is selecte... Read More
Inventors: Smith, Robert L.; Lee, Ta-Jyh; Cragoe, Jr., Edward J.;, Assignee: Merck & Co., Inc. (Rahway, NJ) |
Methylation of de-A steroids
We claim: 1. In a process wherein a de A-steroid of the formula ##STR6## wherein R' is a ketalized 3-oxobutyl; 3-chloro-2-butenyl; 3-methyl-3-butenyl; 3-(lower alkoxy)-2-butenyl; 3-(lower alkoxy)-3-bu... Read More
Inventors: Buchschacher, Paul; Furst, Andor; Labler, Ludwig; Meier, Werner; Scott, John William;, Assignee: Hoffmann-La Roche, Inc. (Nutley, NJ) |
Antibiotic LL-E19085
OF THE INVENTION The antibacterial agents LL-E19085.alpha., LL-E19085.beta., LL-E19085.gamma., LL-E19085.zeta. and LL-E19085.eta. are produced by aerobic fermentation of microbial culture LL-E19085 w... Read More
Inventors: Carter, Guy T.; Goodman, Joseph J.; Labeda, David P.;, Assignee: American Cyanamid Company (Wayne, NJ) |
Amino-substituted imidazo[1,2-a:3,4-a']diquinolin-15-ium salts compositions and method of use
What is claimed is: 1. A compound having the formula I: ##STR45## wherein R.sub.1 is hydrogen, lower alkyl, C.sub.4 -C.sub.6 cycloalkyl, di(lower alkyl)amino, 1-azetidinyl, 1-pyrrolidinyl, 1-piperidin... Read More
Inventors: Capps, David B.; Angelo, Mario M.; Culbertson, Townley P.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Process for producing benzonitrile
What is claimed is: 1. A process for producing benzonitrile comprising reacting toluene with ammonia at a temperature within the range of from 340.degree. to 480.degree. C in the presence of oxygen or... Read More
Inventors: Rizaev, Ramiz Gasan Kuli ogly; Mekhtiev, Soltan Dzhafarovich; Magerramova, Zemfira Jusif kyzy; Sheinin, Viktor Efimovich; Mirataev, Mirabdulla Mirakhmed ogly; Guseinov, Idris Aslan ogly;, Assignee: |
Percutaneous absorption type pharmaceutical preparation of isosorbide dinitrate or pentaerythritol tetranitrate in pressure-sensitive laminate
OF THE INVENTION Polymers having a glass transition temperature (Tg) (measured using a differential scanning colorimeter) of less than -70.degree. C. are not suitable for use in the invention in that... Read More
Inventors: Otsuka, Saburo; Yoshikawa, Toshiyuki; Tokuda, Shoichi; Ito, Yuuseke;, Assignee: Nitto Electric Industrial Co., Ltd. (Osaka, JP); Toa Eiyo Ltd. (Tokyo, JP) |
Waterproof sunscreen compositions
What I claim is: 1. A water-proof sunscreen composition comprising: A. from about 15% to about 90% by weight of a monohydric alcohol; B. from about 0.1% to about 40% by weight of a water-insoluble pol... Read More
Inventors: Palinczar, Victor;, Assignee: |
4-Hydroxy-2-benzimidazoline-thione compounds and pharmaceutical compositions containing them
What is claimed is: 1. 4-Hydroxy-2-benzimidazoline-thione compound of the formula ##STR8## wherein R is lower alkyl of up to 6 carbon atoms; R.sub.1 and R.sub.2, which can be the same or different, ar... Read More
Inventors: Ross, Carl H.; Friebe, Walter-Gunar; Kampe, Wolfgang; Bartsch, Wolfgang; Roesch, Egon;, Assignee: Boehringer Mannheim GmbH (Mannheim, DE) |
Insecticidal combinations
I claim: 1. An insecticidal composition containing as active ingredient a combination of (a) 3,4-dihydro-2-(2-pyropynyl)isocarbostyril, and (b) a pyrethroid of the formula ##STR3## wherein R is hydrog... Read More
Inventors: Sanborn, James R.;, Assignee: Shell Oil Company (Houston, TX) |
Method for the separation and recovery of furfural and organic volatile acids, such as acetic acid and formic acid, from the process of preparation of furfural
What I claim is: 1. A method for the separation and recovery of furfural and volatile organic acids from a vapor mixture containing water, methanol, furfural and volatile organic acids, the vapor mixt... Read More
Inventors: Puurunen, Juhani;, Assignee: |
|
Vasodialators 
