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| Latest patents |
Results: 211-240 of 1119
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Substituted hydroxy pyridones
What is claimed is: 1. A compound of the formula ##STR8## where R.sub.1 represents lower alkyl or cycloalkyl, R.sub.2 represents hydrogen, halo having an atomic weight of about 19 to 36, lower alkyl o... Read More
Inventors: Nadelson, Jeffrey;, Assignee: Sandoz, Inc. (E. Hanover, NJ) |
Methyl 1-(3,4-dichlorobenzyl)-2,3-dioxoisonipecotate
What is claimed: 1. Methyl 1-(3,4-dichlorobenzyl)-2,3-dioxoisonipecotate.
Description:
This invention is concerned with the chemical compound methyl 1-(3,4-dichlorobenzyl)-2,3-dioxoisoni... Read More
Inventors: Schwan, Thomas J.;, Assignee: Morton-Norwich Products, Inc. (Norwich, NY) |
Tetrazolyl containing naphthyridine 3-carboxamides
We claim: 1. A compound of the formula ##SPC5## or the formula ##SPC6## in which R.sub.1 represents a hydrogen atom, a halogen atom, a C.sub.2 -.sub.6 alkenyl or a C.sub.1 -.sub.6 alkyl group; or a gr... Read More
Inventors: Ellis, Gwynn Pennant; Collins, Ian; Waters, David Martin; Bays, David Edmund;, Assignee: Allen & Hanburys Limited (London, EN) |
Phosphorus-containing squalene synthetase inhibitors, new intermediates and method
What is claimed is: 1. A compound having the structure ##STR41## wherein R.sup.5 is OH or Cl and Q is ##STR42## or a bond; and Z is --(CH.sub.2)n- or -(CH.sub.2)p-CH.dbd.CH-(CH.sub.2)m-, wherein n is ... Read More
Inventors: Biller, Scott A.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Substituted aminoalkylphosphinic acids
We claim: 1. A method of treatment of spinal spasticity, multiple sclerosis, cerebral palsy, trigeminus neuralgia, drug withdrawal syndromes and/or conditions of pain, wherein a GABA.sub.B agonistic e... Read More
Inventors: Hall, Roger G.; Maier, Ludwig; Frostl, Wolfgang;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Process for purifying cyanuric acid
OF THE INVENTION In accordance with the invention, cyanuric acid which contains as a contaminant an enclosed residue of a polar solvent is purified and freed of the polar solvent. The contaminated cy... Read More
Inventors: Den Otter, Marinus J. A. M.; Schouteten, Augustinus P. H.; Hawinkels, Lambertus P. G.;, Assignee: Stamicarbon B.V. (Geleen, NL) |
Process for the recovery of nicotinamide
What is claimed is: 1. A process for the recovery of nicotinamide from the reaction mixture resulting from the aqueous hydrolysis of nicotinonitrile at elevated temperature comprising converting the n... Read More
Inventors: Beschke, Helmut; Friedrich, Heinz; Muller, Klaus-Peter; Schreyer, Gerd;, Assignee: Deutsche Gold- Und Silber-Scheideanstalt vormals Roessler (Frankfurt, DE) |
2-substituted amino-4, 6-di-tertiary-buthyl-5-hydroxy-1, 3-pyrimidines as antiinflammatory agents
OF THE INVENTION "Heteroaromatic ring" means pyridinyl, pyrimidinyl, pyrrolyl, pyrazinyl, triazinyl, oxazolyl, isoxazolyl, pyrazolyl, pyridazinyl, imidazolyl, thiazolyl, isothiazolyl, thiadiazolyl, o... Read More
Inventors: Belliotti, Thomas R.; Connor, David T.; Kostlan, Catherine R.;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Conversion of poly(tetramethylene ether) glycol in aqueous effluent stream to tetrahydrofuran
OF THE INVENTION To obtain practicable levels of depolymerization of PTMEG and the concomitant formation of THF, it is essential that the process be carried out at temperatures of 150.degree.-200.deg... Read More
Inventors: Baker, Melvin Charles;, Assignee: E.I. DuPont de Nemours and Company (Wilmington, DE) |
Dihydroxyacryl
What is claimed is: 1. A terpolymer prepared by the copolymerization of: in major amount, an acrylyl unit of the formula ##STR20## Where R.sub.3 is H, R.sub.5 is H or Ch.sub.3, and R.sub.4 is benzyl, ... Read More
Inventors: Weigel, Paul H.;, Assignee: Board of Regents, University of Texas (Austin, TX) |
Odorless aromatic dialdehyde disinfecting and sterilizing composition
We claim: 1. An odorless high level disinfecting and sterilizing composition comprising an aqueous solution containing from 0.025 to 2.0 weight percent of phthalaldehyde, wherein said solution has dis... Read More
Inventors: Bruckner, Norman I.; Gordon, Michael D.; Howell, Ronald G.;, Assignee: Surgikos, Inc. (Arlington, TX) |
Amino acid derivatives
OF THE INVENTION The invention in its broad aspects includes substituted acyl derivatives of amino acids having formula I above. The substituted acyl groups refer to the side chains on the carbon bet... Read More
Inventors: Ondetti, Miguel A.; Condon, Michael E.;, Assignee: E. R. Squibb & Sons, Inc. (Princeton, NJ) |
Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
The invention relates to octahydro-1-(.omega.-mercaptoalkanoyl)-1H-indole-2-carboxylic acid compounds having the formula ##STR1## wherein R is hydrogen or lower alkyl; R.sub.1 is hydrogen, lower alky... Read More
Inventors: Hoefle, Milton L.; Bobowski, George;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Amino acid derivatives, methods of preparing said derivatives and antihypertensive drugs containing them
What is claimed as new and desired to be secured by Letters Patent of the United States is: 1. An amino acid derivative represented by the formula: ##STR8## wherein: R.sub.1 and R.sub.2 are the same o... Read More
Inventors: Sakakibara, Shumpei; Yugari, Yasumi; Hashimoto, Shigebumi;, Assignee: Ajinomoto Company Incorporated (Tokyo, JP) |
N-substituted amino acids as intermediates in the preparation of acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
The invention relates to substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid compounds having the formula ##STR1## where R is hydrogen, lower alkyl or aralkyl; R.sub.1 is... Read More
Inventors: Hoefle, Milton L.; Klutchko, Sylvestor;, Assignee: Warner-Lambert Company (Morris Plains, NJ) |
Rat hypothalamic GRF
OF PREFERRED EMBODIMENTS The nomenclature used to define the peptides is that specified by Schroder & Lubke, "The Peptides", Academic Press (1965), wherein in accordance with conventional representat... Read More
Inventors: Spiess, Joachim; Rivier, Jean E. F.; Vale, Jr., Wylie W.;, Assignee: The Salk Institute for Biological Studies (San Diego, CA) |
Esterified 2-amino pyrimidine derivatives
We claim: 1. A pyrimidine derivative selected from the group consisting of compounds having the formula: ##SPC10## and the hydrochloride salts thereof, wherein R.sub.1 and R.sub.2 are hydrogen, lower ... Read More
Inventors: Snell, Brian Kenneth; Ghosh, Ranajit;, Assignee: Imperial Chemical Industries Limited (London, EN) |
1-Ethoxy-3,4-dihydroisoquindines
I claim: 1. 1-(QO)-3-(Y)-4-(Y')-6-(Z)-7-(Z')-3,4-dihydroisoquinoline of the formula ##STR17## wherein Q is methyl, ethyl or propyl; Y is hydrogen or atertiary alkyl of one to four carbon atoms; Y' is ... Read More
Inventors: Diana, Guy D.;, Assignee: Sterling Drug Inc. (New York, NY) |
N-(phenylalkylamino-alkyl)-dihydroisoquinolinones, pharmaceutical compositions and methods employing them
We claim: 1. A compound of the formula ##STR23## wherein R.sub.1, R.sub.2 and R.sub.6 are each hydrogen or alkyl of 1 to 3 carbon atoms; R.sub.3 is alkoxy of 1 to 3 carbon atoms; R.sub.4 is alkoxy of ... Read More
Inventors: Eberlein, Wolfgang; Heider, Joachim; Austel, Volkhard; Dammgen, Jurgen; Kadatz, Rudolf;, Assignee: Boehringer Ingelheim GmbH (Ingelheim am Rhein, DE1) |
Monoazo pigments derived from aminophthalimides and substituted acetoacetarylides or 2-hydroxy-3-naphthoylarylides
What is claimed is: 1. A monoazo pigments compound of the formula ##STR12## wherein X is a group of the formula ##STR13## R is hydrogen or methyl, R.sub.1 and R.sub.2 are hydrogen, chlorine, methyl or... Read More
Inventors: Cseh, Georg; Hari, Stefan;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Method of labeling complex metal chelates with radioactive metal isotopes
What I claim is: 1. A method of labeling a complex metal chelate compound with a radioactive metal isotope, comprising the steps of; a. providing a radioactive metal isotope dopant and a complex metal... Read More
Inventors: Nath, Amar;, Assignee: Drexel University (Philadelphia, PA) |
Process for the manufacture of 1,4-disubstituted bicyclic or tricyclic compounds and new 1,4-disubstituted bicyclic compounds
What I claim is: 1. A process for the manufacture of bicyclic or tricyclic compounds of formula ##STR57## wherein R.sub.1.sup.v ' represents hydrogen, halogen, alkyl, alkoxy, carboxy, sulpho, --SO.sub... Read More
Inventors: Guglielmetti, Leonardo;, Assignee: Ciba-Geigy Corporation (Ardsley, NY) |
Process for the manufacture of an N-hydroxyalkylcarbazole
What is claimed is: 1. The process for manufacturer of an N-hydroxyalkylcarbazole of the formula ##STR7## wherein R is H, CH.sub.3 or C.sub.2 H.sub.5 and n is a number from 0 to 4 which comprises reac... Read More
Inventors: Tappe, Horst;, Assignee: Cassella Aktiengesellschaft (Frankfurt (M) Fechenheim, DE) |
10-Piperazino-4H-thieno[2,3-c] [1]benzazepines
I claim: 1. A compound of formula I, ##SPC11## where R.sub.1 is hydrogen, halogen, or alkyl, alkoxy or alkylthio of 1 to 4 carbon atoms, or trifluoromethyl, and R.sub.2 is hydrogen, or alkyl, hydroxya... Read More
Inventors: Hunziker, Fritz;, Assignee: Sandoz Ltd. (Basel, CH) |
Certain muscle relaxant 3-methyl-2-benzofuran acetamides
OF THE INVENTION This invention relates to novel benzo[b]furan derivatives represented by the general formula (I): ##STR2## (wherein R.sub.1 represents an alkyl group having 1-4 carbon atoms, an alko... Read More
Inventors: Takizawa, Hiroshi; Enomoto, Yutaka; Oiji, Yoshimasa; Hirayama, Tatsuyuki; Hashimoto, Tamotu;, Assignee: Kyowa Hakko Kogyo Co., Ltd. (Tokyo, JP) |
Vincamine derivatives, their preparation and therapeutical use
What I claim is: 1. A process for preparing a compound of the formula ##STR3## in which: R.sub.1 represents a chlorine atom in the 10-position R.sub.2 and R.sub.3 represent together an additional carb... Read More
Inventors: Hannart, Jean A. A. J.;, Assignee: Omnichem Societe Anonyme (Brussels, BE) |
Substituted 1,3-dihydrospiro(isobenzofuran)s
We claim: 1. A compound of the formula ##SPC4## in which R is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, trifluoromethyl, halogen, hydroxy, or methylenedioxy; R.sub.1 is hy... Read More
Inventors: Bauer, Victor J.; Kosley, Jr., Raymond W.;, Assignee: American Hoechst Corporation (Bridgewater, NJ) |
5-[1-Hydroxy-2-(substituted-amino)]alkyl-8-substituted-carbostyril and -3,4-dihydrocarbostyril derivatives
OF THE INVENTION The term "alkyl" as used herein for R.sup.1, R.sup.2 R.sup.3, R.sup.4 and R.sup.5 means a straight or branched chain alkyl group having 1 to 4 carbon atoms, and includes, for example... Read More
Inventors: Nakagawa, Kazuyuki; Yoshizaki, Shiro; Tanimura, Kaoru; Tamara, Shigeharu;, Assignee: Otsuka Pharmaceutical Company Limited (Tokyo, JA) |
2,3-Dihydro-3-oxo-5H-pyrido[3,4-b][1,4]-benzothiazine-4-carbonitriles
What is claimed is: 1. A compound of the formula ##STR21## wherein R represents hydrogen or a straight-chain alkyl containing 1 to 3 carbon atoms; R' and R" each represent hydrogen or straight-chain o... Read More
Inventors: Chorvat, Robert J.;, Assignee: G. D. Searle & Co. (Skokie, IL) |
1,4-Dithiino pyrazine tetracarbonitriles
What is claimed is: 1. A compound selected from the group consisting of 1,4-dithiino(2,3-b)pyrazine-2,3,6,7-tetracarbonitrile and 1,4-dithiino(2,3-b) (5,6-b')dipyrazine-2,3,7,8-tetracarbonitrile. 2. T... Read More
Inventors: Mixan, Craig E.; Pews, R. Garth;, Assignee: The Dow Chemical Company (Midland, MI) |
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Vasodialators 
