Antihypertensive tricyclic isoindole derivatives
OF THE INVENTION The term "lower alkyl" as used herein means straight chain alkyl radicals containing from one to six carbon atoms and branched chain alkyl radicals containing three or four carbon at... Read More
Inventors: Demerson, Christopher A.; Humber, Leslie G.; Ferland, Jean-Marie;, Assignee: American Home Products Corporation (New York, NY) |
Piperidines derivatives and their use as serotonin receptor antagonists
We claim: 1. A compound of the formula: ##STR94## wherein A is hydrogen, OH or (C.sub.1 -C.sub.6) alkoxy: B is selected from the group consisting of: ##STR95## ##STR96## {character pullout}represents ... Read More
Inventors: He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko;, Assignee: Eli Lilly and Company (Indianapolis, IN) |
Pharmaceutical compositions for the treatment of conditions associated with decreased blood flow
OF THE INVENTION The compounds of the present invention, which are selective to the .beta.2 containing nicotinic acetylcholine receptors, include compounds of the Formula I: ##STR1## where X is nitro... Read More
Inventors: Bencherif, Merouane; Lippiello, Patrick Michael;, Assignee: |
Cyclic pro-perfumes having modifiable fragrance raw material alcohol release rates
OF THE INVENTION The present invention relates to cyclic pro-perfumes capable of releasing at least one fragrance raw material alcohol. Surprisingly, the cyclic pro-perfumes of the present invention ... Read More
Inventors: Miracle, Gregory Scot; Price, Kenneth Nathan; Gray, Lon Montgomery;, Assignee: The Procter & Gamble Company (Cincinnati, OH) |
Nursing bottle utilizing air pressure to expel air from disposable liners and methods using same for feeding an infant
Accordingly, it is an object of the present invention to provide nursing bottles, especially intended for human infants or animals, which utilize air pressure to collapse a liner and expel air from th... Read More
Inventors: Ida, Frank; Di Scala, Luciano;, Assignee: |
Oral composition containing particles comprising an active substance
I claim: 1. An oral composition in dry form adapted to be reconstituted in an aqueous carrier, the composition comprising a multiplicity of solid particles which have sizes and shapes such that they n... Read More
Inventors: Ibsen, Lars S.;, Assignee: A/S Alfred Benzon (Copenhagen, DK) |
Nitrosated and nitrosylated .alpha.-adrenergic receptor antagonist compounds, compositions and their uses
OF THE INVENTION The term "lower alkyl" as used herein refers to branched or straight chain alkyl groups comprising one to ten carbon atoms, including methyl, ethyl, propyl, isopropyl, n-butyl, t-but... Read More
Inventors: Garvey, David S.; Schroeder, Joseph D.; Saenz de Tejada, Inigo;, Assignee: NitroMed, Inc. (Bedford, MA) |
Antiproliferative substituted 5-thiapyrimidinone and 5-selenopyrimidinone compounds
What is claimed is: 1. A compound having the formula I ##STR39## wherein: A represents sulfur or selenium; Z represents a substituted or unsubstituted mono- or fused or nonfused poly-carbocyclic or he... Read More
Inventors: Varney, Michael D.; Romines, William H.; Palmer, Cynthia L.; Deal, Judith G.;, Assignee: Agouron Pharmaceuticals, Inc. (La Jolla, CA) |
Microspheres useful for therapeutic vascular occlusions and injectable solutions containing the same
What is claimed is: 1. An injectable solution suitable for the embolization of microspheres, which comprises a microsphere having a diameter ranging between about 10 to about 2000 .mu.m wherein said m... Read More
Inventors: Boschetti, Egisto; Brouard, Michel; Drouet, Ludovic; Girot, Pierre; Laurent, Alexandre; Wassef, Michel;, Assignee: Assistance Publique Hopitaux de Paris (Paris, FR); BioSepra S.A. (Villeneuve-la-Garenne Cedex, FR) |
Therapeutic system for dietary health management
In light of the above described need, it is an object of the present invention to provide a dietary health management system which adequately supplies desired levels of macro- and micronutrients. It i... Read More
Inventors: Khoo, Chor San Heng; MacNair, R. David;, Assignee: Campbell Soup Company (Camden, NJ) |
Composition for the prevention and/or treatment of osteoporosis and alterations due to menopause syndrome
What is claimed is: 1. A composition, which comprises: a) propionyl L-carnitine or a pharmacologically acceptable salt thereof; and b) 4',5,7-trihydroxyisoflavone, each being present in an amount effe... Read More
Inventors: Cavazza, Claudio;, Assignee: Sigma-Tau Healthscience S.p.A. (Pomezia, IT) |
Pharmaceutical composition containing diltiazem and angiotensin-converting enzyme inhibitor
What is claimed is: 1. A pharmaceutical composition containing a combination of 10-360 mg of diltiazem and 1-100 mg of an angiotensin-converting enzyme inhibitor, enalapril useful for the treatment of... Read More
Inventors: Cavero, Icilio; Elkik, Francois; Hicks, Peter; Muller, Jean-Claude;, Assignee: Synthelabo (Paris, FR) |
1-bolizazepin-2,5-diones
What we claim is: 1. A method for the treatment of stroke, hypoglycemia, ischemic attack or anoxia comprising administering to a mammal in need of such treatment an effective amount of a compound of f... Read More
Inventors: Harris, Gregory D.; Chapdelaine, Marc J.; Jackson, Paul F.;, Assignee: Zeneca Limited (London, GB2) |
Fungicidal compositions and methods for production thereof
What is claimed is: 1. A particulate composition comprising one or more components selected from dithiocarbamates and bisdithiocarbamoyl disulfides and a moisture content of from about 2.5 to about 20... Read More
Inventors: Guo, Yili;, Assignee: Rohm and Haas Company (Philadelphia, PA) |
Controlled release polypeptide compositions and methods of treating inflammatory bowel disease
OF THE INVENTION The invention described herein is directed to pharmaceutical compositions that provide for the controlled release of an active ingredient in the gastrointestinal cavity of a patient.... Read More
Inventors: Gombotz, Wayne R.; Wee, SiowFong;, Assignee: Immunex Corporation (Seattle, WA) |
Dispersion polymers for ethylene quench water clarification
We claim: 1. A method of removing emulsified oil from ethylene quench water, the method comprising the step of treating the oil-containing water with an effective amount of a dispersion of a water-sol... Read More
Inventors: Byrne, Norman E.; Williams, Belinda K.; Fisher, Sherri L.;, Assignee: Nalco Chemical Company (Naperville, IL) |
Corneal angiogenesis inhibitor
What is claimed is: 1. A method for treating corneal neovasculariztion which comprises: administering an effective amount of interferon .beta. for treating corneal neovascularization by inhibiting the... Read More
Inventors: Sone, Saburo; Kajita, Akemi; Satoh, Yu-ichiro;, Assignee: Toray Industries, Inc. (Tokyo, JP) |
Methods and formulations for use in treating oophorectomized women
OF THE INVENTION Pursuant to the present invention, the regimen comprises a slow-release (or depot) formulation which is effective for an extended period of time. Depending on the composition and mod... Read More
Inventors: Pike, Malcolm C.; Spicer, Darcy V.;, Assignee: University of Southern California (Los Angeles, CA) |
Treatment of sexual dysfunction in certain patient groups
OF THE INVENTION The present invention relates to methods for the treatment of sexual dysfunction in males and females (including but not limited to erectile dysfunction in males) in particular treat... Read More
Inventors: Cutler, Neal R.;, Assignee: Cutler; Neal R. (Los Angeles, CA) |
***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST*** *** NO IMAGES AVAILABLE*** Compositions, methods and devices for the transdermal delivery of drugs
OF THE INVENTION The present invention provides compositions comprising (i) a gelling agent consisting of methylcellulose or at least one natural gum, or a mixture thereof; (ii) at least one natural ... Read More
Inventors: Schmirler, Dennis Lee; Portman, Edward Malcolm; Christensen, Michael S.;, Assignee: |
Treatment of sexual dysfunction in certain patient groups
OF THE INVENTION The present invention relates to methods for the treatment of sexual dysfunction in males and females (including but not limited to erectile dysfunction in males) in particular treat... Read More
Inventors: Cutler, Neal R.;, Assignee: Cutler; Neal R. (Los Angeles, CA) |
Methods of inducing analgesia or anesthesia and treating or preventing ischemic injury of tissues in general
This invention is therefore aimed at solving the above-mentioned shortcoming of adenosinergic approaches, while obtaining either analgesic (anesthetic) or protective effects, thus providing similar or... Read More
Inventors: Miyamoto, Tadaomi; Miyamoto, Koho;, Assignee: Meddiss, Incorporated (Fukuoka, JP) |
Oil composition
What is claimed is: 1. An oil composition, comprising about 0.1 to 59.8% by weight of a triglyceride, about 40 to 99.7% by weight of a diglyceride, about 0.1 to 10% by weight of a monoglyceride, and a... Read More
Inventors: Koike, Shin; Hosoya, Naoki; Yasumasu, Takeshi;, Assignee: Kao Corporation (Tokyo, JP) |
Blocking agents of EDRF effect or formation for the treatment of shock
We claim: 1. A therapeutical composition of matter for the treatment by perfusion of shock states comprising as an essential ingredient therein an effective amount of a compound of the formula: ##STR3... Read More
Inventors: Braquet, Pierre; Chabrier de Lassauniere, Pierre-Etienne; Guillon, Jean-Michel; Auguet, Michel;, Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques (FR) |
Use of polyamines as ionic-channel regulating agents
OF THE PREFERRED EMBODIMENTS The disclosure of any and all cited documents including literature and patent application is incorporated by reference in its entirety. It is understood that in the prese... Read More
Inventors: Cherksey, Bruce D.; Llinas, Rodolfo R.; Sugimori, Mutsuyuki;, Assignee: New York University (New York, NY) |
Inhibitor of ceramidase
It is a general object of the invention to provide a method of selecting compounds that cause intracellular accumulation of ceramide. It is a specific object of the invention to provide a method of id... Read More
Inventors: Hannun, Yusuf A.; Bielawska, Alicja; McKay, Charles;, Assignee: Duke University (Durham, NC) |
Treatment of bone disorders with adrenomedullin
OF THE INVENTION It is believed that one skilled in the art can, based on the description herein, utilize the present invention to its fullest extent. The following specific embodiments are, therefor... Read More
Inventors: Coy, David H.; Cornish, Jillian; Reid, Ian Reginald; Cooper, Garth James Smith;, Assignee: Auckland UniServices Limited (Auckland, NZ); The Administrators of The Tulane Educational Fund (New Orleans, LA) |
99MTC(III) myocardial imaging agents and method of use
OF THE INVENTION The technetium compounds of the present invention which have been found most useful as myocardial imaging agents in humans comprise hexadentate technetium complexes having an overall... Read More
Inventors: Woulfe, Steven R.; Deutsch, Edward A.; Dyszlewski, Mary M.; Neumann, William L.;, Assignee: Mallinckrodt Medical, Inc. (St. Louis, MO) |
1,4-dihydro-4-oxo-3-quinoline derivatives as selectively toxic mammalian antibacterial agents
OF THE INVENTION Compounds of the formula I may be prepared as illustrated in the following reaction scheme. ##STR6## Referring to the above reaction scheme, compounds of the formula I, wherein Q is ... Read More
Inventors: McGuirk, Paul R.;, Assignee: Pfizer Inc. (New York, NY) |
Vaginal sponge delivery system
These and other objects of the invention are achieved in a product which broadly comprises (a) a sealed, air-tight package, enclosing therein (b) a sponge impregnated with the liquid containing an eff... Read More
Inventors: Myhling, John;, Assignee: Gynetech Laboratories, Ltd. (New York, NY) |
Vasodialators 
