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1,3,5 trisubstituted pyrazole compounds for treatment of inflammation
| Details |
Inventors: Talley, John J.; Rogier, Jr., Donald J.;
Assignee: G.D. Searle & Co. (Skokie, IL)
Primary Examiner: Raymond; Richard L.
Assistant Examiner:
Attorney, Agent or Firm: Bulock; Joseph W., Keane; J. Timothy
A class of 1,3,5-triaryl or heteroaryl pyrazoles is described for the treatment of inflammation, including treatment of pain and disorders such as arthritis. Compounds of particular interest are of Formula I ##STR1## wherein R.sup.1 is lower alkylsulfonyl or sulfamyl; wherein R.sup.2 is aryl or heteroaryl; wherein R.sup.2 is optionally substituted at substitutable positions with one or more radicals selected from halo, lower alkoxy, lower alkyl, nitro, lower alkylthio, amino, lower haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; wherein R.sup.3 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, alkoxycarbonyl, amino, acyl, acylamino, halo and alkylsulfonylamino; wherein R.sup.4 is aryl or heteroaryl; wherein R.sup.4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkoxy, lower alkyl, nitro, lower alkylthio, amino, lower haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; provided R.sup.2 and R.sup.4 cannot be phenyl or substituted triazole, when R.sup.1 is sulfamyl; further provided R.sup.2 cannot be 4-methoxyphenyl or 4-methylphenyl when R.sup.4 is 4-methoxyphenyl or 4-methylphenyl and when R.sup.1 is sulfamyl; and further provided that R.sup.2 cannot be tetrazole when R.sup.4 is fluorophenyl, and when R.sup.1 is methylsulfonyl; or a pharmaceutically-acceptable salt thereof. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A compound of Formula I ##STR7## wherein R.
sup.
1 is alkylsulfonyl or sulfamyl; wherein R.
sup.
2 is aryl; wherein R.
sup.
2 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkoxy, alkyl, nitro, alkylthio, amino, haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; wherein R.
sup.
3 is selected from hydrido, alkyl, haloalkyl, cyano, carboxyl, alkoxycarbonyl, amino, acyl, acylamino, halo and alkylsulfonylamino; and wherein R.
sup.
4 is aryl; wherein R.
sup.
4 is optionally substituted at a substitutable position with one or more radicals selected from halo, alkoxy, alkyl, nitro, alkylthio, amino, haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; provided at least one of R.
sup.
2 and R.
sup.
4 cannot be phenyl when R.
sup.
1 is sulfamyl; and further provided R.
sup.
2 cannot be 4-methoxyphenyl or 4-methylphenyl when R.
sup.
4 is 4-methoxyphenyl or 4-methylphenyl, and when R.
sup.
1 is sulfamyl; or a pharmaceutically-acceptable salt thereof.
2.
Compound of claim 1 wherein R.
sup.
1 is lower alkylsulfonyl or sulfamyl; wherein R.
sup.
2 is aryl; wherein R.
sup.
2 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkoxy, lower alkyl, nitro, lower alkylthio, amino, lower haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; wherein R.
sup.
3 is selected from hydrido, lower alkyl, lower haloalkyl, cyano, carboxyl, alkoxycarbonyl, amino, acyl, acylamino, halo and alkylsulfonylamino; and wherein R.
sup.
4 is aryl; wherein R.
sup.
4 is optionally substituted at a substitutable position with one or more radicals selected from halo, lower alkoxy, lower alkyl, nitro, lower alkylthio, amino, lower haloalkyl, hydroxyl, carboxyl, N-monoalkylamino, N,N-dialkylamino, cyano, alkoxycarbonyl and acylamino; provided at least one of R.
sup.
2 and R
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