2-oxo-1,3,4-trihydroquinazolinyl derivatives and methods of use

DETAILED DESCRIPTION What is claimed is: 1.
A compound of formula I ##STR00092## wherein A is O or S; wherein D is selected from CR.
sup.
1, CR.
sup.
2, CR.
sup.
3, CR.
sup.
4 and N; wherein E is selected from CR.
sup.
1, CR.
sup.
2, CR.
sup.
3, CR.
sup.
4 and N; wherein F is selected from CR.
sup.
1, CR.
sup.
2, CR.
sup.
3, CR.
sup.
4 and N; wherein G is selected from CR.
sup.
1, CR.
sup.
2, CR.
sup.
3, CR.
sup.
4 and N; wherein J is selected from NR.
sup.
6, S, O, CR.
sup.
1, CR.
sup.
2, CR.
sup.
3 and CR.
sup.
4; wherein K is selected from NR.
sup.
6, S, O, CR.
sup.
1, CR.
sup.
2, CR.
sup.
3 and CR.
sup.
4; wherein L is selected from NR.
sup.
6, S, O, CR.
sup.
1, CR.
sup.
2, CR.
sup.
3 and CR.
sup.
4; wherein Q is selected from H, hydroxy, --N(R.
sup.
5).
sub.
2, --NR.
sup.
5C(O)R.
sup.
5, --(C.
sub.
1 C.
sub.
8)alkyl-OR.
sup.
5, --(C.
sub.
1 C.
sub.
8)alkyl-S(O).
sub.
nR.
sup.
5, ##STR00093## substituted aryl, an unsubstituted or substituted monocyclic or bicyclic, non-aromatic carbocyclic ring, an unsubstituted or substituted monocyclic or bicyclic, heteroaryl and an unsubstituted or substituted monocyclic or bicyclic, non-aromatic heterocyclic ring, wherein the ring is unsubstituted or substituted with one or more groups selected from H, halo, aryl, alkynyl, alkenyl, --OR.
sup.
5, --N(R.
sup.
5).
sub.
2, --(C.
sub.
1 C.
sub.
8)alkyl-N(R.
sup.
5).
sub.
2, --(C.
sub.
1 C.
sub.
8)alkyl-S(O).
sub.
nR.
sup.
5, --N(R.
sup.
5).
sub.
2(C.
sub.
1 C.
sub.
8)alkyl-N(R.
sup.
5).
sub.
2, lower alkoxyalkyl, --S(O).
sub.
nR.
sup.
5, --NR.
sup.
5S(O).
sub.
nR.
sup.
5, cyano, (C.
sub.
1 C.
sub.
8)alkyl, lower cyanoalkyl, lower alkylaminoalkoxy, lower aminoalkoxyalkyl (C.
sub.
3 C.
sub.
10cycloalkyl, nitro, optionally substituted 4 7 membered heterocyclyl, optionally substituted phenoxyalkyl, optionally substituted heterocyclyloxyalkyl, --SO.
sub.
2NR.
sup.
5R.
sup.
5, --NR.
sup.
5SO.
sub.
2R.
sup.
5, --C(O)N(R.
sup.
5).
sub.
2, --CO.
sub.
2R.
sup.
5, --CO.
sub.
2NR.
sup.
5R.
sup.
5, --SO.
sub.
2NHC(O)R.
sup.
5, optionally substituted phenylalkyl, optionally substituted heterocyclylalkyl, --NR.
sup.
5C(O)N(R.
sup.
5).
sub.
2, --NR.
sup.
5C(O)R.
sup.
5, --NR.
sup.
5CO.
sub.
2R