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Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
| Details |
Inventors: Sunshine, Abraham; Laska, Eugene M.; Siegel, Carole E.;
Assignee: Richardson-Vicks, Inc. (Shelton, CT)
Primary Examiner: Friedman; Stanley J.
Assistant Examiner:
Attorney, Agent or Firm: Burns, Doane, Swecker & Mathis
Novel pharmaceutical compositions of matter are provided comprising analgesic/non-steroidal anti-inflammatory drugs and diphenhydramine and methods of using said compositions to elicit an enhanced analgesic and/or anti-inflammatory response in mammalian organisms in need of such treatment. |
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DETAILED DESCRIPTION What is claimed is: 1.
A method for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism (i) an analgesically and anti-inflammatorily effective amount of mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid or tolfenamic acid, or a pharmaceutically acceptable salt thereof; and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine.
2.
The method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of mefenamic acid.
3.
The method as defined by claim 1, wherein the component (i) comprises analgesically and anti-inflammatorily effective amount of meclofenamic acid.
4.
The method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of flufenamic acid.
5.
The method as defined by claim 1, wherein the component (i) comprises an analgesically and anti-inflammatorily effective amount of niflumic acid.
6.
The method as defined by claim 1, wherein the component (i) comprises and analgesically and anti-inflammatorily effective amount of tolfenamic acid.
7.
The method as defined by claim 1, comprising from about 125 mg of component (i).
8.
The method as defined by claim 1, comprising from about 12.
5 mg to 50 mg diphenhydramine.
9.
The method as defined by claim 8, comprising from about 25 mg to 50 mg of diphenhydramine.
10.
The method as defined by claim 1, wherein said composition is administered orally.
11.
The method as defined by claim 1, wherein said component (i) is administered daily in divided doses.
12.
The method as defined by claim 1, wherein said composition is administered orally at bedtime as an analgesically and anti-inflammatory effective nighttime sleep aid.
13.
A pharmaceutical composition of matter for eliciting an enhanced analgesic and anti-inflammatory response in a mammalian organism, said composition comprising: (i) an analgesically and anti-inflammatorily effective amount of mefenamic acid, meclofenamic acid, flufenamic acid, niflumic acid or tolfenamic acid, or a pharmaceutically acceptable salt thereof; and (ii) an analgesically and anti-inflammatorily potentiating amount of diphenhydramine
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