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 Anti-protozoal treatment

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Inventors: Miller, Richard L.;
Assignee: Burroughs Wellcome Co. (Research Triangle Park, NC)
Primary Examiner: Robinson; Allen J.
Assistant Examiner:
Attorney, Agent or Firm: Brown; Donald

3'-Azido-3'-deoxythymidine is disclosed as an effective treatment for giardiasis.

DETAILED DESCRIPTION I claim: 1.
A method for treating giardial infection of a mammal in need of treatment comprising the administration to said mammal of an effective, non-toxic antigiardial amount of a compound of formula (I) ##STR3## or a pharmaceutically acceptable salt thereof.
2.
A method according to claim 1 wherein said mammal is a human being.
3.
A method according to claim 1 wherein said compound is administered in association with a pharmaceutically acceptable carrier therefor.
4.
A method according to claim 3 wherein said compound is in a form suitable for oral, rectal or parenteral administration.
5.
A method according to claim 4 wherein said compound is in unit dosage form.
6.
A method according to claim 1 which comprises the administration to said mammal of from 1 to 100 mg per kg of body weight per day of said compound.
7.
A method according to claim 6 wherein from 2 to 50 mg per kg of body weight per day of said compound is administered to said mammal.
8.
A method according to claim 6 wherein from 3 to 40 mg per kg of body weight per day of said compound is administered to said mammal.
9.
A method for treating giardial infection of a mammal in need of said treatment thereof comprising the administration of said mammal of an effective, non-toxic antigiardial amount of a compound of formula (I) ##STR4## or its 5'-mono-, 5'-di-, or 5'-triphosphate or a pharmaceutically acceptable salt thereof.
10.
A method according to claim 9 wherein said mammal is a human being.
11.
A method according to claim 9 wherein said 5'-monophosphate is administered.
12.
A method of treating a Giardia lamblia infection in a human suffering from same which comprises internally administering an effective Giardia lamblia treatment amount of the compound 3.
sup.
1 -azido-3.
sup.
1 -deoxythymidine or a pharmaceutically acceptable salt thereof to said human.
13.
The method of claim 12 in which a tablet or capsule containing the compound or salt is orally administered.
14.
The method of claim 12 in which an injectable preparation containing the compound or salt is parenterally adminstered



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