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Home Weight Loss and Supplements Antidiabetic-3-4-5-trihydroxypiperidines

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 Antidiabetic 3,4,5-trihydroxypiperidines

Details
Inventors: Junge, Bodo; Krause, Hans P.; Muller, Lutz; Puls, Walter;
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Primary Examiner: Schwartz; Richard A.
Assistant Examiner:
Attorney, Agent or Firm: Sprung Horn Kramer & Woods

The invention includes certain 3,4,5-trihydroxypiperidine compounds, methods for their preparation, compositions containing said 3,4,5-trihydroxypiperidine compounds and methods for the use of said compounds and compositions. The subject matter of the invention is useful against diabetes, hyperlipaemia and adiposity as well as in animal nutrition.

DETAILED DESCRIPTION What is claimed is: 1.
A compound of the formula ##STR264## in which R.
sub.
1 is C.
sub.
5 -C.
sub.
30 alkyl, C.
sub.
2 -C.
sub.
18 alkenyl, C.
sub.
2 -C.
sub.
18 alkinyl, C.
sub.
3 -C.
sub.
8 cycloalkyl, C.
sub.
3 -C.
sub.
8 cycloalkenyl, C.
sub.
3 -C.
sub.
8 -cycloalkinyl, phenyl (a), C.
sub.
1 -C.
sub.
2 and C.
sub.
7 -C.
sub.
30 alkyl substituted by phenyl (b) or substituted C.
sub.
1 -C.
sub.
4 -alkyl said C.
sub.
5 -C.
sub.
30 alkyl, cycloalkyl, cycloalkenyl and cycloalkinyl being unsubstituted or substituted by hydroxy, C.
sub.
1 -C.
sub.
4 -alkoxy, acyloxy, amino, mono- C.
sub.
1 -C.
sub.
4 alkylamino, di-C.
sub.
1 -C.
sub.
4 alkylamino, acylamino, mercapto, C.
sub.
1 -C.
sub.
4 alkylthio, halogen, C.
sub.
1 -C.
sub.
4 alkylcarbonyl, carboxyl nitro, cyano, formyl, sulfo, a heterocyclic radical derived from a hexose or pentose, attached to the alkyl moiety directly via a ring atom or via an --O--, --S-- or --NH-bridge or naphthyl said phenyl (a) being unsubstituted or substituted by C.
sub.
1 to C.
sub.
10 alkyl, C.
sub.
1 to C.
sub.
10 chloroalkyl, C.
sub.
1 to C.
sub.
10 nitroalkyl, C.
sub.
1 to C.
sub.
10 cyanoalkyl, C.
sub.
1 to C.
sub.
10 alkenyl, hydroxyl, C.
sub.
1 to C.
sub.
4 alkoxy, amino, mono-C.
sub.
1 to C.
sub.
4 alkylamino, di-C.
sub.
1 -C.
sub.
4 alkylamino, mercapto, C.
sub.
1 -C.
sub.
4 alkylthio, carboxyl, C.
sub.
1 -C.
sub.
4 carbalkoxy, sulfo, C.
sub.
1 -C.
sub.
4 alkylsulfonyl, phenylsulfonyl, aminosulfonyl, C.
sub.
1 -C.
sub.
4 alkylaminosulfonyl, di-C.
sub.
1 -C.
sub.
4 alkylaminosulfonyl, nitro, cyano, formyl, C.
sub.
1 -C.
sub.
4 alkylcarbonylamino, C.
sub.
1 -C.
sub.
4 alkylcarbonyl, benzoyl, benzylcarbonyl or phenylethylcarbonyl; said substituted C.
sub.
1 -C.
sub.
4 alkyl being substituted by hydroxy, C.
sub.
1 -C.
sub.
4 -alkoxy, acyloxy, amino, mono- C.
sub.
1 -C.
sub.
4 alkylamino, di-C.
sub.
1 -C.
sub.
4 alkylamino, acylamino, mercapto, C.
sub.
1 -C.
sub.
4 alkylthio, halogen, C.
sub.
1 - C.
sub.
4 alkylcarbonyl, carboxyl nitro, cyano, formyl, sulfo, a heterocyclic radical derived from a hexose or pentose, attached to the alkyl moiety directly via a ring atom or via an --O--, --S-- or --NH--bridge or naphthyl, said acyl being derived from an aliphatic carboxylic acid having from 1 to 7 C-atoms, a phenyl carboxylic acid, unsubstituted or substituted by carboxy, hydroxy, halogen, C



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