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Bicyclic-carbohydrates-as-antiviral-bioactives-for-the-treatment-of-infections-caused-by-the-alphaherpesvirinae-HSV-1-and-HSV-2

Zeaxanthin formulations for human ingestion

This invention discloses zeaxanthin preparations which contain the 3R-3'R stereoisomer of ...

Method of making pure 3R-3'R stereoisomer of zeaxanthin for human ingestion

This invention discloses a method of making a preparation of zeaxanthin which contains the 3R-3'R ...

Low phosphorus animal feed containing 1.alpha.-hydroxylated vitamin D compounds and method of preparing

OF THE PREFERRED EMBODIMENT As used in the description and in the claims, the term hydroxy-...

Polynucleotide molecule from Haematococcus pluvialis encoding a polypeptide having a beta-C-4-oxygenase activity for biotechnological production of (3S, 3'S) astaxanthin and its specific expression in chromoplasts of higher plants

It is a general object of this invention to provide a biotechnological method for production of (3S,...

DNA strands useful for the synthesis of xanthophylls and the process for producing the xanthophylls

What is claimed is: 1. A method for producing a xanthophyll comprising: (a) introducing a DNA ...

Isolation and formulations of nutrient-rich carotenoids

OF THE INVENTION A principal object of the present invention is to provide a pharmacologically and ...

Copolymers of flavanoid tannins and acrylic monomers

OF THE PREFERRED EMBODIMENTS By suitable choice of tannins and comonomers, a wide variety of ...

Method of controlling release of antimicrobial agents in chewing gum

OF THE PREFERRED EMBODIMENTS In the context of this invention, chewing gum refers to chewing gum, ...

Fatigue recovery medicine for changing in hepatic mRNA levels of stress-related genes

Accordingly, an object of the present invention is to solve the foregoing problems by providing a ...

Herbal drug composition for the prevention and treatment of dementia

OF THE INVENTION This invention is explained in more detail as set forth hereunder: This invention ...

Bicyclic carbohydrates as antiviral bioactives for the treatment of infections caused by the alphaherpesvirinae HSV-1 and HSV-2

Details

Inventors: Sas, Benedikt; Van hemel, Johan; Vandenkerckhove, Jan; Peys, Eric; Van Der Eycken, Johan; Van Hoof, Steven;
Assignee: Kemin Pharma Europe B.V.B.A. (Des Moines, IA)
Primary Examiner: Chang; Celia
Assistant Examiner:
Attorney, Agent or Firm: Herink; Kent A. Rosenberg; Daniel A. Harris; Emily E.

Novel bicyclic carbohydrate compounds are effective for the prophylaxis and treatment of diseases caused by infections of the alphaherpesvirinae HSV-1 and HSV-2. The invention includes the compound ##STR00001## wherein X.sub.1, X.sub.2, and X.sub.3 are selected from the group consisting of O, N, and S; wherein Y.sub.1 and Y.sub.2 are selected from the group consisting of O, N, and S; and wherein Z is selected from the group consisting of F, Cl, and Br, as well as analogs, prodrugs and pharmaceutically acceptable salts thereof, together with pharmaceutical compositions for the prophylaxis and treatment of diseases caused by infections of alphaherpesvirinae.

DETAILED DESCRIPTION The invention consists of the novel bicyclic carbohydrate the structure of which is illustrated in FIG.
1 and which is identified herein as Formula A.
Compounds of Formula A have activity against infections caused by the alphaherpesvirinae HSV-1 and HSV-2.

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