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Home Weight Loss and Supplements Composition-for-external-application-containing-a-beta-1-6-branched-beta-1-3-glucan

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 Composition for external application containing a .beta.-1,6-branched-.beta.-1,3-glucan

Details
Inventors: Park, Kyung Mok; Park, Byung Hwa; So, Sung; Kim, Mu Sung; Kim, Jung Su; Kim, Young Taek; Lee, Sung Gu; Lee, Dong Chul;
Assignee: Pacific Corporation (Seoul, KR)
Primary Examiner: Saucier; Sandra E.
Assistant Examiner: Afremova; Vera
Attorney, Agent or Firm: Foley & Lardner

Disclosed herein is a process for liquid cultivating Schizophyllum commune Fr. for isolation of .beta.-1,6-branched-.beta.-1,3-glucan and a composition for external application containing .beta.-1,6-branched-.beta.-1,3-glucan as an active ingredient, which can defer skin aging, impart skin whitening effect and cure skin damage effectively.

DETAILED DESCRIPTION OF THE INVENTION Schizophyllum commune Fr.
is woody rotting fungi belonging to Agaricales Tricholomataceae Schizophyllum of basidiomycetes in classification by Singer R.
(The Agaricales in modern taxonomy, 1975) and excretes .
beta.
-1,6-branched-.
beta.
-1,3-glucan to the extracellular.
It may be obtained in wild and identified by the following morphology or taxonomic characteristics: Its fruiting body has a size of 1.
0.
about.
3.
0 cm with no stipe and a shell-like shape with longitudinal gills and hair-densed edge The gill is white, but turns light grey or light purplish brown when it becomes ripe.
Its flesh tends to shrivel, but to revive by absorbing moisture.
The spore print is white.
And, the spore has a cylindrical shape with a size of 4.
times.
1.
5 .
mu.
m.
about.
6.
times.
2 .
mu.
m and is smooth and white.
The Schizophyllum commune Fr.
is scattered in a cluster on dead tree or stub of hardwood.
Its regimen and shape are described in more detail in "Illustrated Book of Korean Fungus"(Sam soon KIM et al.
, YooPoong Press, 1990) and "The Agaricales in modern taxonomy"(Singer, R.
, 1975).
.
beta.
type glucose bonds such as .
beta.
-1,3-bond, .
beta.
-1,4-bond, .
beta.
-1,6-bond are generally named as .
beta.
-glucan without specific distinction.
But, actually, the bond type is very various depending on its origin, so as to have different physical or chemical properties and biological function.
That is to say, .
beta.
-glucan, depending on its origin, has different composition of constituent sugars, branch degree, molecular weight or 3-D structure.
For example, the .
beta.
-glucan of Ganoderma licidum is mainly isolated from the cell wall and minorly from the extracellular and has a bond of glucose, mannose and galactose.
The .
beta.
-glucan of Coriolus versicolor is mainly isolated from the cell wall and has .
beta.
-1,3-bond and .
beta.
-1,4-bond.
The .
beta.
-glucan of Lentinus edodes is isolated from the cell wall and is .
beta.
-1,6-branched-.
beta.
-1,3-glucan having two .
beta.
-1,6-bonds branched to every five



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