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Composition for the treatment of cutaneous mycosis
| Details |
Inventors: Marrodan, Carlos Alberto;
Assignee:
Primary Examiner: Pak; John
Assistant Examiner:
Attorney, Agent or Firm:
The inventions relates to the use of silica in the formulation of antifungal composition for the treatment of cutaneous mycoses, and method to manufacture an antifungal powder with boric acid and silica. |
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DETAILED DESCRIPTION I claim: 1.
An antifungal powder composition for the treatment of cutaneous mycosis that consists essentially of 70 to 99 weight percent natural quartz and at least one antifungal agent selected from the group consisting of organic antifungal agents and boric acid, and mixtures thereof.
2.
An antifungal powder composition according to claim 1, wherein said antifungal agent is an azole derivative.
3.
An antifungal powder composition according to claim 2, wherein the azole derivative is selected from the group consisting of miconazole, clotrimazole and econazole, and mixtures thereof.
4.
An antifungal powder composition according to claim 1, wherein said antifungal agent is selected from the group consisting of undecylenic acid, haloprog in, clioquinol, tolnaftate and povidone-iodine, and mixtures thereof.
5.
An antifungal powder composition according to claim 1, wherein said antifungal agent is selected from the group consisting of boric acid, tannic acid, salicylic acid and benzoic acid, and mixtures thereof.
6.
A method of preparing an antifungal powder composition comprising the steps of: (a) Preparing a solution that contains between 0.
1 to 5 wt.
% boric acid and 0.
1 to 5 wt.
% tannic acid in a solvent selected from the group consisting of warm distilled water, warm demineralized water and alcohol; (b) Wetting an amount of silica powder (mesh 325) with the same weight amount of said solution to obtain a creamy consistency; and (c) Drying and grinding the dried lumps to a powder to obtain the antifungal powder composition.
Description:
BACKGROUND OF THE INVENTION The present invention relates to the use of silica powder as dispersing agent and filler with antifungal drugs for the treatment of fungal infection of the skin.
The present invention further relates to a method to manufacture an antifungal powder.
Most drugs currently available for the treatment of mycoses have limited efficacy, because they are used in low concentration owing to their high toxicity
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