Corosolic acid formulation and its application for weight-loss management and blood sugar balance

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Corosolic acid (2-a-hydroxyursolic acid, CAS# 52213-27-1; Glucosol.
TM.
(trademark of Soft Gel Technologies, Inc.
of Los Angeles, Calif.
) is a triterpenoid with a molecular weight of 743.
63 grams and is a lipophilic, polar compound that is extracted from the leaves of Lagerstroemia Speciosa L.
Lagerstroemia Speciosa L.
is commonly known as Crepe Myrtle and belongs to the botanical family lythraceae.
It is a very common ornamental deciduous tree that grows in the tropical areas of the globe.
Tea preparations from the leaves of Lagerstroemia Speciosa L.
, traditionally have been used for weight-loss and by diabetics to balance blood sugar levels (Murakami et.
al.
, 1993).
Both in-vitro and in-vivo studies on the glucose transporter stimulatory effects of extracts from Lagerstroemia Speciosa L.
, have been described previously, including the identification of Corosolic acid (2-a-hydroxyursolic acid, CAS# 52213-27-1), a triterpenoid, as the active principle of this extract and its hypoglycemic effect (Murakami et.
al.
, 1993; Yamasaki, 1996; De Tommasi N, De Simone W I, Ho F, Sirino G, Cicala C, Pizza C, Hypoglycemic effects of sesquiterpene glycosides and polyhydroxylated triterpenoids of Eriobotrya japonica, Planta Meica, 57, 414, 1991; Garcia, F.
On the Hypoglycemic Effect of Decoction of Lagerstroemia Speciosa leaves (Banaba) Administered Orally.
The Journal of the Philippine Medical Association, 22, #7, 395402, 1940; Garcia, F.
Distribution and Deterioration of Insulin-like Principle in Lagerstroemia Speciosa (Banaba).
Acta Medica Philippina, 99-104; Garcia, F.
, and Melencio-Maglalang, P.
Application of Banabins (A Plantisul Preparation) and S.
B.
Menus to Diabetics.
The Journal of the Philippine Medical Association, 33, #1, 7-16, 1957; Garcia, F.
Criticisms and Answers on Published Articles concerning Banabins or Plantisul Tablets.
The Journal of the Philippine Medical Association, 35, #5, 313-319, 1959; Garcia, L.
, Pojas, F.
Castro, I.
, Venzon, E