 Chlorite in the treatment of neurodegenerative disease |
| The invention features methods of treating a macrophage-associated neurodegenerative disease such ... |
|
| Pharmaceutical composition using albumin as a carrier and process for producing the same |
| I claim: 1. A process for producing a pharmaceutical composition comprising mixing together at high ... |
|
| Stabilized composition of levothyroxine sodium medication and method for its production |
| OF THE INVENTION The present invention discloses a new composition for levothyroxine sodium ... |
|
| Liquisolid systems and methods of preparing same |
| OF THE DRAWINGS FIG. 1 is a schematic outline of steps involved in the preparation of liquisolid ... |
|
| Stabilized medicaments containing thyroid hormones |
| We claim: 1. Stable medicaments containing thyroid hormones, wherein said medicaments comprise ... |
|
| Areca food additives and its foods |
| A series of eatable compounds for preparation areca food additive, which have an excellent effect ... |
|
| Beverage compositions for human consumption |
| OF THE PRESENT INVENTION The present invention is based on a number of new discoveries and ... |
|
|
Herbal-based composition for treating acute and chronic myeloid leukemia
| Details |
Inventors: Bandyopadhyay, Santu; Roy, Keshab Chandra; Ray, Mitali; Banerjee, Goutam; Pal, Bikash Chandra; Biswas, Tanusree; Bhattacharya, Samir;
Assignee: Council of Scientific and Industrial Research (New Delhi, IN)
Primary Examiner: Flood; Michele
Assistant Examiner:
Attorney, Agent or Firm: Fitzpatrick, Cella, Harper & Scinto
A new herbal-based composition and method for treatment of CD33+ acute and chronic myeloid leukemia by Piper betel leaf extracts, and to provide a process for the isolation of active fractions from leaves or any other plant parts of Piper betel to treat CD33+ AML and CML with a simplified method of isolation of active components from all plant parts of Piper betel possessing biological activities relevant to the treatment of CD33+ AML and CML. |
|
DETAILED DESCRIPTION 1.
A method of treating either CD33+ acute myeloid leukemia or CD33+ chronic myeloid leukemia by administering a pharmaceutically effective amount of compound 3-O-p-coumaryl quinic acid to a subject in need thereof.
2.
A method as claimed in claim 1, wherein the compound has 100% activity against CD33+ chronic myeloid leukemia.
3.
A method as claimed in claim 1, wherein the compound has 85% activity against CD33+ chronic myeloid leukemia.
4.
A method as claimed in claim 1, wherein the subject is an animal.
5.
A method as claimed in claim 1, wherein the subject is a human being.
6.
A method as claimed in claim 1, wherein the administering is intravenous.
Description:
FIELD OF INVENTION This invention relates to a herbal based composition for treatment of CD33+ acute and chronic myeloid leukemia by Piper betel leaf extracts, fractions of Piper betel leaf extracts and 3-O-p-coumaryl quinic acid purified from Piper betel leaves extract.
BACKGROUND AND PRIOR ART REFERENCES Mycloid leukemia, both acute (AML) and chronic (CML) are lethal, there is no drug directing towards the destruction of the myeloid cells and these cells poorly respond to chemotherapy, which is always non-specific, thus adversely affecting normal cells.
Unique property of the therapy with Piper betel components is the killing of myeloid cancer cells by recognizing CD33+ marker on the cell membrane, leaving normal cells without getting affected.
Myeloid leukemia is usually subdivided into two groups: Acute Myeloid Leukemia (AML) and Chronic Myeloid Leukemia (CML).
AML is characterized by an increase in the number of myeloid cells in the bone marrow and an arrest in their maturation.
In the United States, the annual incidence of AML is approximately 2.
4 per 100,000 and it increases progressively with age, to a peak of 12.
6 per 100,000 in adults of 65 years age or older.
The CML is a malignant clonal disorder of hematopoietic stem cells.
The median age at presentation is 53 years, but it occurs at all age groups, including children
|
| Related patents |
|
|
Stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20%
We claim: 1. A process for the preparation of stable, pulverulent lycopene formulations, comprising lycopene having a degree of crystallinity of greater than 20%, which ...
|
|
|
Cosmetic compositions with agglomerated substrates
OF PREFERRED EMBODIMENTS Below, the invention is explained in more detail by means of examples. All percentage references relate to weight (mass) unless otherwise ...
|
|
|
Emulsifier-free finely disperse systems of the oil-in-water and water-in-oil type
The invention claimed is: 1. Pickering emulsions, which are finely disperse water-in-oil or oil-in-water systems, comprising (1) an oil phase, (2) an aqueous phase, (3) ...
|
|
|
Isolates of pythium species which are antagonistic to Pythium ultimum
What is claimed is: 1. A biologically pure culture of Pythium isolate N2 having the identifying characteristics of ATCC 20692. 2. A biologically pure culture of Pythium ...
|
|
|
Bacterial substance and pharmaceutical composition thereof
AND PREFERRED EMBODIMENT The term "treatment" used herein is intended to cover all the controls of diseases including prevention, sustention (i.e. prevention of ...
|
|
|
Compounds, compositions, and methods for controlling biofilms
This invention relates to compounds, compositions, and methods for controlling biofilms. "Controlling" a biofilm means disrupting a biofilm and/or preventing biofilm ...
|
|
|
Cosmetic make-up composition containing a fullerene or mixture of fullerenes as a pigmenting agent
I claim: 1. A cosmetic composition in the form of an oil-in-water or water-in-oil emulsion containing an effective amount of fullerene or mixture of fullerenes as a ...
|
|
|
Benzylidenenorcamphor derivatives
What is claimed is: 1. A method for screening the skin or hair from the sun comprising applying to the skin or hair a benzylidenenorcamphor compound of the formula I ##ST...
|
|
|
Cosmetic compositions comprising a film-forming polymer a citric acid ester and a plasticizing agent
We claim: 1. A cosmetic composition for forming a film on skin, eyelashes, eyebrows, hair, or nails comprising: (a) at least one film-forming polymer; (b) at least one ...
|
|
|
Triazine derivatives
What is claimed is: 1. A cosmetic preparation, comprising at least one triazine compound of the formula ##STR60## in which R is halogen; straight-chain or branched C.sub....
|
|
|
Weight Loss and Supplements 
