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| Nitroglycerin-containing polymeric matrix for sustained release on topical application |
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Hollow porous ceramic carrier for embedding in patient for sustained medicament release and method of preparation thereof
| Details |
Inventors: Hakamatsuka, Yasuharu; Irie, Hiroyuki; Horie, Gen;
Assignee: Olympus Optical Co., Ltd. (Tokyo, JP)
Primary Examiner: Bawa; Raj
Assistant Examiner:
Attorney, Agent or Firm: Frishauf, Holz, Goodman, Langer & Chick, P.C.
An improved porous ceramic body to be embedded in a patient for sustained release of a medicament, and a method of making the ceramic body is provided. To control the release of the medicament, the pores of the ceramic body decrease in diameter from the inner surface to the outer surface of the body whereby the pore diameter is substantially proportional to the distance from the outer surface of the carrier. First, raw ceramic slurry is made from the blend of .beta.-TCP, deflocculating agent, and water. Next, using a syringe the ceramic slurry is supplied to the internal region of a solvent-absorbable mold from an aperture along the inner wall surface. Then, the ceramic slurry is quickly dehydrated before thinly adhering itself onto the inner wall surface of the mold. Therefore, a preformed body having a hollow is obtained. Next, after fully being dried, the dried preformed body is fired at 1,050.degree. C. for an hour before eventually yielding a spherical carrier for use in sustained release preparation. Substantially, the carrier is composed of a porous ceramic body which having the hollow for retaining the medicament and permits permeation of the medicament. The pore diameter corresponding to the peak value of the distribution thereof decreases toward to the outer periphery of the preformed body and yet, width of the distribution of the pore diameter becomes narrower. |
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DETAILED DESCRIPTION The primary object of the invention is to provide a novel carrier for use in sustained release preparation, which is capable of selectively providing an optimum amount of a medicament to the affected part for a long period of time after being buried in the patient's body.
Another object of the invention is to provide a novel carrier for use in sustained release preparation, which is capable of stably maintaining the sustained release characteristic of a medicament without varying it at all.
Another object of the invention is to provide a novel method for manufacturing a carrier for sustained release preparation to permit manufacturers to easily produce the carrier.
Specifically, the invention provides a novel carrier for use in sustained release preparation, which comprises a porous ceramic body having a cavity for retaining a medicament and which controls release of the medicament.
The porous ceramic body is capsule-shaped and has pores extending inwardly of the outer periphery thereof, each of which has a diameter substantially proportional to the distance from a outer periphery of the porous ceramic body.
Furthermore the present invention provides a novel carrier for use in sustained release preparation, which comprises a porous ceramic body having a hollow for retaining a medicament and which controls release of the medicament, wherein the porous ceramic body is capsule-shaped and has pores, and has a pore rate which decrease toward to the outer periphery of the porous ceramic body.
Furthermore, the present invention provides a novel method for manufacturing a carrier for use in sustained release preparation, which carrier comprises a porous ceramic body having a hollow for retaining a medicament and controls release of the medicament.
The method comprises a step of preparing a raw material ceramics slurry, a step of preparing a preformed body containing a hollow by causing the raw material ceramic slurry to adhere on an inner wall surface of a solvent-absorbable mold, a step of firing the preformed body, thereby obtaining the porous ceramic body is capsule-shaped and has pores, each of which has a diameter substantially proportional to the distance from a outer periphery of the porous ceramic body
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