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Implantable biocompatible immunoisolatory vehicle for the delivery of selected therapeutic products
| Details |
Inventors: Dionne, Keith E.; Emerich, Dwaine F.; Hoffman, Diane; Sanberg, Paul R.; Christenson, Lisa; Hegre, Orion D.; Scharp, David W.; Lacy, Paul E.; Aebischer, Patrick; Vasconcellos, Alfred V.; Lysaght, Michael J.; Gentile, Frank T.;
Assignee: Neurotech S.A. (Evry, FR)
Primary Examiner: Bawa; Raj
Assistant Examiner:
Attorney, Agent or Firm: Mintz, Levin, Cohn, Ferris, Glovsky and Pope, P.C., Elrifi; Ivor R., Karnakis; Christina V.
An immunoisolatory vehicle for the implantation into an individual of cells which produce a needed product or provide a needed metabolic function. The vehicle is comprised of a core region containing isolated cells and materials sufficient to maintain the cells, and a permselective, biocompatible, peripheral region free of the isolated cells, which immunoisolates the core yet provides for the delivery of the secreted product or metabolic function to the individual. |
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DETAILED DESCRIPTION OF THE INVENTION This invention relates to a biocompatible immunoisolatory vehicle suitable for long-term implantation into individuals.
More particularly, the biocompatible immunoisolatory vehicle of the instant invention comprises (a) a core which contains a biologically active moiety, either suspended in a liquid medium or immobilized within a hydrogel or extracellular matrix, and (b) a surrounding or peripheral region of permselective matrix or membrane (jacket) which does not contain isolated cells, which is biocompatible, and which is sufficient to protect isolated cells if present in the core from immunological attack.
The term "individual" refers to a human or an animal subject.
A "biologically active moiety" is a tissue, cell, or other substance, which is capable of exerting a biologically useful effect upon the body of an individual in whom a vehicle of the present invention containing a biologically active moiety is implanted.
Thus, the term "biologically active moiety" encompasses cells or tissues which secrete or release a biologically active molecule, product or solute; cells or tissues which provide a metabolic capability or function, such as the removal of specific solutes from the bloodstream; or a biologically active molecule or substance such as an enzyme, trophic factor, hormone, or biological response modifier.
When the biologically active moiety within the core of the biocompatible immunoisolatory vehicle comprises cells, the core is constructed to provide a suitable local environment for the continued viability and function of the cells isolated therein.
The instant vehicle can be used to immunoisolate a wide variety of cells or tissues, spanning the range from fully-differentiated, anchorage-dependent cells or primary tissues, through incompletely-differentiated fetal or neonatal tissues, to anchorage-independent transformed cells or cell lines.
Many transformed cells or cell lines are most advantageously isolated within a vehicle having a liquid core
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