Medicinal plasters

Details

Inventors: von Bittera, Miklos;
Assignee: Bayer Aktiengesellschaft (Leverkusen, DE)
Primary Examiner: Rosenbaum; C. Fred
Assistant Examiner: Colosimo; Mark
Attorney, Agent or Firm: Sprung Horn Kramer & Woods

A medicinal plaster comprising a covering layer, a reservior layer for an active compound and a detachable protective layer is disclosed. The covering is a substantially impermeable material comprising a textile sheet-like structure which is longitudinally and transversely elastic and is impregnated or coated with a polymer. Disposed on such a covering layer is a reservior layer comprising 1 to 30% by weight of active compound is an elastomeric mixture comprising a polyisobutylene polymer, a carrier such as a polybutadiene oil or liquid paraffin and a resin such as a polybutadiene oil or liquid paraffin and a resin such as a adhesion-conferring resin. Methods for the formation of such medicinal plaster and the use of such medicinal plaster, especially to apply large dosages of antiinflammatory materials are disclosed.

DETAILED DESCRIPTION What is claimed is: 1.
A medicinal plaster comprising a covering layer, a reservoir layer for an active compound and a detachable protective layer which is substantially impermeable to the active compound, said reservoir layer containing 1 to 30% by weight of an active compound and an elastomer comprising a polyisobutylene polymer, a carrier and a resin, said covering layer being substantially impermeable to said active compound and comprising a textile sheet-like structure which is longitudinally and transversely elastic and is impregnated or coated with a polymer.
2.
A medicinal plaster according to claim 1 wherein said resin is an adhesion-conferring resin.
3.
A medicinal plaster according to claim 2 wherein said carrier is a polybutadiene oil, liquid paraffin or mixture thereof.
4.
A medicinal plaster according to claim 3 wherein said covering layer is impregnated with a polymer.
5.
A medicinal plaster according to claim 3 wherein said covering layer is coated with a polymer.
6.
A medicinal plaster according to claim 1 wherein said polyisobutylene polymer is one having a molecular mass distribution M.
sub.
w /M.
sub.
n of 1.
5 to 3.
5 and a viscosity average of molecular mass of 30,000 to 4,000,000, said active compound is an antiinflammatory agent and said covering layer consists essentially of a textile sheet-like structure which is impermeable to said active compound, is longitudinally and transversely elastic, and is impregnated or coated with a polymer.
7.
A medicinal plaster according to claim 6 wherein said molecular mass distribution M.
sub.
w /M.
sub.
n is 2.
0 to 3.
0.
8.
A medicinal plaster according to claim 6 wherein said polyisobutylene polymer is a polyisobutylene homopolymer.
9.
A medicinal plaster according to claim 6 wherein said polyisobutylene polymer is a polyisobutylene copolymer with 1 to 5 mol percent of a conjugated diene.
10.
A medicinal plaster according to claim 1 wherein said reservoir contains 30 to 60% by weight of polyisobutylene polymer, 30 to 60% by weight of carrier and 2 to 40% by weight of resin in addition to said active compound

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