Method for chemoprevention of prostate cancer

DETAILED DESCRIPTION This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of administering to a subject an effective dose of an antiestrogen to prevent, prevent recurrence of, and/or suppress or inhibit prostate carcinogenesis.
This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of administering to a subject an effective dose of an antiestrogen which does not cause the formation of DNA adducts, to prevent, prevent recurrence of, and/or suppress or inhibit prostate carcinogenesis.
This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of administering to a subject an effective dose of a chemopreventive agent, toremifene and analogs or metabolites thereof, to prevent, prevent recurrence of, and/or suppress or inhibit prostate carcinogenesis.
The present invention is directed to a method for preventing prostate carcinogenesis with an antiestrogen which does not cause the formation of DNA adducts.
Further, this invention involes administering to a mammalian subject a pharmaceutical preparation of a chemopreventive agent having the formula: ##STR1## wherein R.
sub.
1 and R.
sub.
2, which can be the same or different, are H or OH, R.
sub.
3 is OCH.
sub.
2 CH.
sub.
2 NR.
sub.
4 R.
sub.
5, wherein R.
sub.
4 and R.
sub.
5, which can be the same or different, are H or an alkyl group of 1 to about 4 carbon atoms; and their pharmaceutically acceptable carrier, diluents, salts, esters, or N-oxides, and mixtures thereof.
The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having an elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.