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Method for preparing film coated pharmaceutical preparations and method for improving properties thereof
| Details |
Inventors: Kokubo, Hiroyasu; Sekigawa, Fujio; Chiba, Tohru; Onda, Yoshiro;
Assignee: Shin-Etsu Chemical Co., Ltd. (Tokyo, JP)
Primary Examiner: Cashion, Jr.; Merrell C.
Assistant Examiner: Horne; Leon R.
Attorney, Agent or Firm: Parkhurst, Wendel & Rossi
Film coated pharmaceutical preparations, which are prepared by overlaying to the outer surface of pharmaceutical preparations, a coating layer comprising at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethylethyl cellulose and cellulose acetate phthalate, are irradiated with light including ultraviolet rays. Whereby film coated pharmaceutical preparations, the coating layer surface of which are excellent in whiteness, are prepared. Moreover, as a content of a white pigment in corporated into the coating layer of such preparations may be reduced, the stability of such preparations can be enhanced without impairing the strength of the coating layer. |
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DETAILED DESCRIPTION What is claimed is: 1.
A method for providing white colored film coated pharmaceutical preparations, said method comprising the steps of providing pharmaceutical preparations having a film coating material containing moisture, and irradiating said film coating with ultra violet rays to partially oxidize the material to a Yellowness Index in the range of about 5.
1 to 9.
8, wherein said film coating material comprises at least one member selected from the group consisting of methyl cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose phthalate, hydroxypropylmethyl cellulose acetate succinate, carboxymethyl cellulose and cellulose acetate phthalate.
2.
The method of claim 1 wherein said ultraviolet rays have a wavelength in the range of 200 nm to 380 nm.
3.
The method of claim 1 wherein said mositure content is at least 0.
3 percent.
4.
The method of claim 1 wherein said moisture content is at least 1.
3 percent.
5.
The method of claim additionally comprising drying during the irradiating.
Description:
BACKGROUND OF THE INVENTION The present invention relates to a method for preparing film coated pharmaceutical preparations composed of a solid drug and a coating layer on the outer surface thereof and a method for improving properties of film coated pharmaceutical preparations likewise comprised of a solid drug and a coating layer on the outer surface thereof, which makes it possible to impart an excellent appearance to the film coated pharmaceutical preparations.
Heretofore, solid drugs such as tablets have been subjected to film coating treatment to form film coated pharmaceutical preparations therefrom.
Such a coated film serves to prevent uncomfortable tastes of drugs from giving out therefrom, as well as to protect effective components of the drugs from causing property change and to control the releasing behaviors of the effective components in the digestive system after an administration thereof.
In view of enhancing the reliability of drugs and the acceptability of their appearance as medicines, it has been desired to impart a snow white and beautiful finish to such a coating layer
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