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| Method of treating livestock footbath solutions |
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| Process for preparing reduced alcoholic spirits and the product produced therefrom |
| OF THE PREFERRED EMBODIMENT In the process disclosed herein, a batch of distilled spirits at ... |
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| Nicotine metabolites and nicotine dependence |
| OF THE INVENTION Cotinine ##STR1## Cotinine has the molecular structure shown above; The ... |
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Method of causing the reduction of physiological and/or subjective reactivity to stress in humans being subjected to stress conditions
| Details |
Inventors: Warren, Craig B.; Munteanu, Marina A.; Schwartz, Gary E.; Benaim, Carlos; Walter, Jr., Henry G.; Leight, Ronald S.; Withycombe, Donald A.; Mookherjee, Braja D.; Trenkle, Robert W.;
Assignee: International Flavors & Fragrances Inc. (New York, NY); Yale University (New Haven, CT)
Primary Examiner: Rose; Shep K.
Assistant Examiner:
Attorney, Agent or Firm:
Described is a method for reducing physiological and/or subjective reactivity to stress in humans being subjected to stress conditions. The method consists of administering to such humans an effective amount of a physiological and/or subjective stress reactivity-reducing substance selected from the group consisting of: (i) Nutmeg Oil; (ii) Mace Extract; (iii) Neroli Oil; (iv) Valerian Oil; (v) Myristicin; (vi) Isoelemicin; and (vii) Elemicin. Administration is through inhalation or transdermally using one or more of the above ingredients alone or in a suitable composition such as ethanol and/or a perfume composition, cologne or perfumed article (e.g., air freshener or deodorant stick). Also described is a method for detecting the reduction of physiological and/or subjective reactivity to stress in a human. |
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DETAILED DESCRIPTION OF THE INVENTION Our invention necessarily also involves a method for detecting physiological and/or subjective reactivity to stress in a human comprising testing a human likely to exhibit physiological and/or subjective reactivity by: (i) measuring the initial blood pressure and mood of said human; then (ii) administering stress to said human by means of application of a stressor; (iii) simultaneously measuring blood pressure change and mood change resulting from the application of said stress to said human; thereafter (iv) administering a postulated stress reactivity-reducing substance to said human; and (v) simultaneously measuring the blood pressure change and mood change in said human resulting from the application of said postulated stress reactivity-reducing substance during the application of said stressor to said human.
As has already been pointed out, our invention is directed to a method for causing the reduction of physiological and/or subjective reactivity to stress in a human being subjected to stress conditions which comprises administering to said human an effective amount of a substance which may be one or a mixture of: Nutmeg oil; Mace extract; Neroli oil; Valerian oil; Myristicin having the structure: ##STR6## Elemicin having the structure: ##STR7## and/or Isoelemicin having the structure: ##STR8## taken alone or taken further together with a carrier which may be a perfumed article or cologne and/or ethanol.
Insofar as the nutmeg oil, mace extract, neroli oil and valerian oil are concerned, the various varieties of such materials are useful in the practice of our invention.
Thus, for example, Nutmeg Oil East Indian or Nutmeg Oil West Indian are useful in the practice of our invention.
Standard commercial mace extract is useful in our invention as is the more highly purified form thereof.
Commercial valerian oil is useful in the practice of our invention as is the refined version, doubly distilled valerian oil.
In addition, naturally occurring or synthetically produced myristicin, elemicin and isoelemicin are useful in the practice of our invention
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