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Method-of-inhibiting-aldose-reductase-activity

.alpha.-glucosidase inhibitors

What is claimed is: 1. 1-deoxy nojirimycin derivatives of the formula ##STR5## and the ...

Oxetanones

OF THE INVENTION As used herein, the term "alkyl" denotes a straight or branched chain alkyl ...

Process for the preparation of .alpha.-glucosidase inhibitor, pradimicin Q

OF THE INVENTION One aspect of the present invention provides the compound pradimicin Q and its ...

Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same

We claim: 1. A compound of the Formula (I) ##STR7## wherein R is a C.sub.1 to C.sub.12 alkyl group ...

Inhibitor of absorption of digestion product of food and drink

OF THE INVENTION The following examples are to explain this invention in detail, not to limit its ...

Hydantoin derivatives for treating complications of diabetes

OF PREFERRED EMBODIMENTS The invention will now be further explained with reference to M...

Oral composition

OF THE INVENTION Although the present invention is described below with reference to examples, the ...

Formulation for administration of steroid compounds

OF THE INVENTION By 5.beta. steroid is meant .alpha. ET, .beta. ET, and ED. In addition certain ...

Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals

OF THE PREFERRED EMBODIMENTS The term "melanocortin receptor" as used herein refers to proteins ...

Methods for regulating levels of zinc, cadmium and calcium in humans and for diagnosing, or screening for the risk of developing, diseases associated with abnormal levels of cadmium, zinc and calcium in body fluids and tissues

OF THE INVENTION It is known that stallions have low fertility (e.g. unsuccessful equine in vitro ...

Method of inhibiting aldose reductase activity

Details

Inventors: York, Jr., Billie M.;
Assignee: Alcon Laboratories, Inc. (Fort Worth, TX)
Primary Examiner: Schenkman; Leonard
Assistant Examiner:
Attorney, Agent or Firm: Fitch, Even, Tabin & Flannery

Inhibition of aldose reductase activity with tetracyclic spiro-hydantoins.

DETAILED DESCRIPTION What is claimed is: 1.
A method for treating diabetic complications in mammals comprising administering an effective amount of spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione or pharmaceutically acceptable salt thereof having the formula ##STR24## where x=H, F, Cl, Br, I, SCH.
sub.
3, S(O)CH.
sub.
3, S(O.
sub.
2)CH.
sub.
3, OCH.
sub.
3 and CH.
sub.
3, y=H, F, Cl, Br, I, SCH.
sub.
3, S(O)CH.
sub.
3, S(O.
sub.
2)CH.
sub.
3, OCH.
sub.
3 and CH.
sub.
3, and z=H, F, Cl, Br, I, OCH.
sub.
3 and CH.
sub.
3.
2.
A method as recited in claim 1 wherein said complication is diabetic cataract.
3.
A method as recited in claim 1 wherein said complication is neuropathy.
4.
A method as recited in claim 1 wherein said complication is retinopathy.
5.
A method as recited in claim 1 wherein said complication is nephropathy.
6.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR25## 7.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula.
##STR26## 8.
A method in accordance with claims 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR27## 9.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR28## 10.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR29## 11.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR30## 12.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR31## 13.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR32## 14.
A method in accordance with claims 1, 2, 3, 4 or 5 wherein said spiro-(fluoren-9,4'-imidazolidine)-2',5'-dione has the formula ##STR33## 15

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