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Method of protecting human skin from ultraviolet radiation
| Details |
Inventors: Warner, Jr., Paul L.; Zusi, F. Christopher;
Assignee: Westwood Pharmaceuticals Inc. (Buffalo, NY)
Primary Examiner: Jiles; Henry R.
Assistant Examiner: Ramsuer; R. W.
Attorney, Agent or Firm: Simon; Morton S.
Reaction of 4-nitrophenacyl bromide with morpholine affords the novel intermediate 1-(4-nitrophenyl)-2-morpholinylethanone which when reduced yields the novel sunscreen 1-(4-aminophenyl)-2-morpholinylethanone. |
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DETAILED DESCRIPTION We claim: 1.
A method for protecting human skin from ultraviolet radiation comprising applying to the skin to be protected an effective ultraviolet radiation-absorbing amount of 1-(4-aminophenyl)-2-morpholinylethanone in a vehicle suitable for topical administration.
2.
The method, according to claim 1, wherein the 1-(4-aminophenyl)-2-morpholinylethanone is present in said vehicle in a concentration of from about 1% to about 10% by weight.
Description:
I.
DESCRIPTION This invention relates to compositions for use in filtering ultraviolet radiation to screen out rays that are harmful to mammalian (human or animal) skin or organic materials, thereby protecting against the burning and degrading effects of such radiation.
It is known that electromagnetic radiation emanating from the sun or from a source of ultraviolet light can have a detrimental and deleterious effect on paints, plastics, and other substances.
It is also known that such radiation is harmful and damaging to human skin since radiation in this range of wavelength causes cutaneous sunburn and has been identified as carcinogenic.
It is also acknowledged that certain radiation can directly or indirectly cause an adverse effect or response to the skin and various organs, particularly in connection with the influence of other agents, such as coal tar extracts and various plant extracts.
More particularly, the influence of sunlight or ultraviolet radiation in connection with the use of drugs can result in adverse effects such as edema, hyperpigmentation, vesicle formation, and exaggerated sunburn.
Other skin disorders such as polymorphic light eruptions and erythematosis are significantly exaggerated by exposure to light in this wavelength range.
Electromagnetic radiation within the ultraviolet and visible spectrum incident upon an object can be blocked by a mechanical barrier, for example, by a film of titanium dioxide, or the like, which prevents passage of all radiation regardless of wavelength.
Another method which permits the greater part of the incident radiation to pass through and which takes out only a specified spectral range depends upon the employment of a selective sunscreen agent
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Weight Loss and Supplements 
