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| Novel cyclopropane carboxylic acid esters |
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| Process for making granules containing urea as the main component |
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| Cephem derivative |
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Methods useful in the treatment of cardiac arrhythmia using 4-substituted-2-iminoimidazolidine compounds
| Details |
Inventors: Cale, Jr., Albert D.;
Assignee: A. H. Robins Company, Inc. (Richmond, VA)
Primary Examiner: Rosen; Sam
Assistant Examiner:
Attorney, Agent or Firm:
This invention provides a novel class of 2-iminoimidazolidines which include 4-substituted derivatives such as 4-(2-chloroethyl)-1-methyl-2-methylimino-3-phenyl imidazolidine fumarate: ##STR1## This illustrated 4-substituted 2-iminoimidazolidine compound exhibits cardiovascular hypotensive, hypoglycemic (glucose tolerance, and sugar cataract) and anti-inflammatory (pleural effusion) pharmacological activities in test animals. |
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DETAILED DESCRIPTION What is claimed is: 1.
The method for the treatment of cardiac arrhythmia in a patient comprising administering a pharmaceutical carrier and a cardiac arrhythmia inhibiting quantity of a 2-iminoimidazolidine compound corresponding to the formula: ##STR35## wherein R is loweralkyl; R.
sup.
1 is a member selected from hydrogen, loweralkyl, phenyl, loweralkylphenyl, and chlorophenyl; R.
sup.
2 is a member selected from loweralkyl, phenyl, loweralkylphenyl, and chlorophenyl; X is a member selected from amino, diloweralkylamino, di(phenylloweralkyl)amino, 1-piperidino, 1-piperazino, 1-morpholino, and chloro; and n is the integer 1 or 2, or a pharmaceutically acceptable acid addition salt thereof.
2.
The method in accordance with claim 1 wherein the 2-iminoimidazolidine compound is 4-(2-chloroethyl)-1-ethyl-2-imino-3-phenylimidazolidine or a pharmaceutically acceptable acid addition salt thereof.
3.
The method in accordance with claim 1 wherein the 2-iminoimidazolidine compound is 4-(2-chloroethyl)-3-(p-chlorophenyl)-1-ethyl-2-iminoimidazolidine or a pharmaceutically acceptable acid addition salt thereof.
4.
The method in accordance with claim 1 wherein the 2-iminoimidazolidine compound is 4-(2-chloroethyl)-1-ethyl-2-imino-3-(2,6-dimethylphenyl) imidazolidine or a pharmaceutically acceptable acid addition salt thereof.
5.
The method in accordance with claim 1 wherein the 2-iminoimidazolidine compound is 4-(2-chloroethyl)-3-(3-chloro-4-methylphenyl)-1-ethyl-2-iminoimidazolidine or a pharmaceutically acceptable acid addition salt thereof.
6.
The method in accordance with claim 1 wherein the 2-iminoimidazolidine compound is 4-(2-chloroethyl-1,3-dimethyl-2-phenyliminoimidazolidine or a pharmaceutically acceptable acid addition salt thereof.
Description:
BACKGROUND OF THE INVENTION There are a number of organic compounds listed in the chemical literature which contain a 2-iminoimidazolidine nucleus: ##STR2## Among the known compounds are 1-[p-(2-aminoethyl)-phenylsulfonyl]-3-butyl-4-ethyl-2-iminoimidazolidine and 1-cyclohexyl-2-imino-4-methyl-3-(p-tolylsulfonyl)imidazolidine
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