 Inhibitor of absorption of digestion product of food and drink |
| OF THE INVENTION The following examples are to explain this invention in detail, not to limit its ... |
|
| Hydantoin derivatives for treating complications of diabetes |
| OF PREFERRED EMBODIMENTS The invention will now be further explained with reference to M... |
|
| Oral composition |
| OF THE INVENTION Although the present invention is described below with reference to examples, the ... |
|
| Formulation for administration of steroid compounds |
| OF THE INVENTION By 5.beta. steroid is meant .alpha. ET, .beta. ET, and ED. In addition certain ... |
|
| Geldanamycin derivatives and antitumor drug |
| OF THE PREFERRED EMBODIMENTS The Geldanamycin derivatives having the formula (I) can be produced ... |
|
| Method and compositions for inhibiting protein kinases |
| We claim: 1. A method for inhibiting a protein kinase, which comprises: contacting a composition ... |
|
|
N-substituted pseudo-aminosugars, their production and use
| Details |
Inventors: Horii, Satoshi; Kameda, Yukihiko; Fukase, Hiroshi;
Assignee: Takeda Chemical Industries, Inc. (Osaka, JP)
Primary Examiner: Hines; Robert V.
Assistant Examiner:
Attorney, Agent or Firm: Wegner & Bretschneider
A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use. These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A compound of the formula: ##STR35## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms which may be substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or a phenyl which may be substituted by hydroxyl, lower alkoxy, lower alkyl or halogen group.
2.
A compound of the formula ##STR36## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms which may be substituted by hydroxyl, phenoxy, cyclohexyl or phenyl which may be substituted with hydroxyl, lower alkoxy, lower alkyl or halogen.
3.
A compound as claimed in claim 1, wherein A is a chain hydrocarbon of 1 to 6 carbon atoms which may be substituted by hydroxyl or phenyl group optionally substituted by halogen.
4.
A compound as claimed in claim 3, namely N-(1,3-dihydroxy-2-propyl)valiolamine.
5.
A compound as claimed in claim 1 or 3, namely N-(.
beta.
-hydroxyphenethyl)valiolamine.
Description:
The present invention relates to N-substituted Pseudo-aminosugars having an inhibitory activity against glucoside hydrolase, to processes for producing the same, and to .
alpha.
-glucosidase inhibitors containing the above-mentioned derivatives.
The present inventors previously isolated as a constituent of validamycin, an antibiotic, the compound of the formula ##STR2## , which was named "valienamine" (Y.
Kameda and S.
Horii; Journal of the Chemical Society; Chemical Communications, 1972, 746 to 747), and reported that valienamine possesses an action of suppressing the function of .
alpha.
-glucoside hydrolase (Y.
Kameda et al.
, Journal of Antibiotics 33, 1575 to 1576 (1980)).
In recent years, various compounds having valienamine moiety, which exhibit .
alpha.
-glycosidase inhibitory activity, are reported e.
g.
"Acarbose" in U.
S.
Pat.
No.
4,062,950, "Trestatin A, B and C" in German laid open patent application No.
2,905,649 but their actions to suppress the function of .
alpha.
-glucoside hydrolase are unsatisfactory.
The present inventors investigated an
|
| Related patents |
|
|
Thiolactam-n-acetic acid derivatives
We claim: 1. A compound of the formula: ##STR11## wherein, R.sup.1 and R.sup.2 are, the same or different, hydrogen, a halogen, a lower alkyl, a cycloalkyl having 3....
|
|
|
Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient
I claim: 1. A rhodanine derivative represented by the general formula: ##STR13## wherein R.sup.11 represents a hydrogen atom; R.sup.22 represents: (1) a 5- to 10-...
|
|
|
Fuel supply systems
We claim: 1. A liquid fuel pump arrangement for delivering liquid fuel to an engine comprising a liquid-ring pump including a motor-driven bladed impeller rotor which is ...
|
|
|
Heterocyclic oxophthalazinyl acetic acids
OF THE INVENTION The numbering system of the compounds of formula I is as shown: ##STR5## The term "(C.sub.1 -C.sub.4)alkyl" whenever used in the definitions of R.sub.1 ...
|
|
|
Spiro-isoquinoline-pyrrolidines and analogs thereof useful as aldose reductase inhibitors
We claim: 1. The compounds of structural formula (I) ##STR5## wherein R.sup.1 and R.sup.2 are independently hydrogen, alkyl containining 1 to 6 carbon atoms, halogen, ...
|
|
|
Novel alpha-glucosidase inhibitor, pradimicin Q
OF THE INVENTION One aspect of the present invention provides the compound pradimicin Q and its pharmaceutically acceptable base salts. "Pharmaceutically acceptable ...
|
|
|
.alpha.-glucosidase inhibitors
What is claimed is: 1. 1-deoxy nojirimycin derivatives of the formula ##STR5## and the pharmaceutically acceptable acid addition salts thereof wherein n is zero, 1 or 2 ...
|
|
|
Oxetanones
OF THE INVENTION As used herein, the term "alkyl" denotes a straight or branched chain alkyl containing the number of carbon atoms designated. Examples of C.sub.1 -C....
|
|
|
Process for the preparation of .alpha.-glucosidase inhibitor, pradimicin Q
OF THE INVENTION One aspect of the present invention provides the compound pradimicin Q and its pharmaceutically acceptable base salts. "Pharmaceutically acceptable ...
|
|
|
Pyridopyrimidine derivatives, pharmaceutical compositions containing them and process for preparing same
We claim: 1. A compound of the Formula (I) ##STR7## wherein R is a C.sub.1 to C.sub.12 alkyl group substituted by C.sub.1 to C.sub.4 alkoxycarbonyl, a C.sub.3 to C.sub.9 ...
|
|
|
Weight Loss and Supplements 
