DETAILED DESCRIPTION OF THE INVENTION Cotinine ##STR1## Cotinine has the molecular structure shown above; The physiologically active form is the (-)-isomer, so as used herein, the term "cotinine" includes (-)-cotinine, or the racemic form, (+/-)-cotinine.
The free base, depicted above, can be employed in the practice of the invention, as can the pharmaceutically acceptable salts.
These include the amine-acid addition salts of nontoxic organic acids or inorganic acids, such as the tartarate, fumarate ("scotine"), citrate, maleate, malate, hydrobromide, hydrochloride, sulfate, phosphate and the like.
For example, see F.
Vaitekunas, J.
Amer.
Chem.
Soc.
, 79, 149 (1957).
E.
R.
Bowman et al.
, in J.
Pharmacol.
Exp.
Ther.
, 135, 306 (1962) report the preparation of (-)-cotinine free base from (-)-nicotine.
The preparation and purification of (-)-cotinine fumarate is described by N.
L.
Benowitz et al.
, Clin.
Pharmacol.
Ther.
, 34, 604 (1983).
Also, see P.
Jacob III, et al.
, in Pharmacol.
Biochem.
Behav.
, 30, 249 (1988) for an explanation of the metabolic pathways of nicotine and the formation of this metabolic product are discussed.
Nornicotine ##STR2## Nornicotine has the molecular structure shown above; The physiologically active form is the (-)-isomer, so as used herein, the term "nornicotine" includes (-)-nornicotine, or the racemic form, (+/-)-nornicotine.
The free base, depicted above, can be employed in the practice of the invention, as can the pharmaceutically acceptable salts.
These include the amine-acid addition salts of nontoxic organic acids or inorganic acids, such as the tartarate, fumarate, citrate, maleate, malate, hydrobromide, hydrochloride, sulfate, phosphate and the like.
For example, see P.
Jacob III, et al.
, in Pharmacol.
Biochem.
Behav.
, 30, 249 (1988) for an explanation of the metabolic pathways of nicotine and the formation of this metabolic product are discussed.
Norcotinine ##STR3## Norcotinine has the molecular structure shown above; The physiologically active form is the (-)-isomer, so as used herein, the term "norcotinine" includes (-)-norcotinine, or the racemic form, (+/-)-norcotinine
|
Weight Loss and Supplements 
