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| Method of disinfecting water |
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| Transdermal therapeutic formulation containing a limonene |
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| Method for removing contaminants from water with the addition of oil droplets |
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| Blood type methods and dietary supplements |
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| Beauty method |
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Over-coated chewing gum formulations including tableted center
| Details |
Inventors: Ream, Ronald L.; Corriveau, Christine L.; Graff, Gwendolyn; Matulewicz, Leonard;
Assignee: Wm. Wrigley, Jr. Company (Chicago, IL)
Primary Examiner: Page; Thurman K.
Assistant Examiner: Howard; S.
Attorney, Agent or Firm: Bell, Boyd & Llyod LLC
Methods and products for delivering a medicament or agent to an individual are provided as well as methods for producing the product. The product includes a coating having a medicament or agent. The medicament or agent is present within the coating that surrounds a tableted gum center (the water soluble portion and a water insoluble base portion). By chewing the gum, the medicament or agent is released from the product. Continuing to chew the chewing gum creates a pressure within the buccal cavity forcing the agent or medicament directly into the systemic system of the individual through the oral mucosa contained in the buccal cavity. This greatly enhances the absorption of the drug into the systemic system as well as the bioavailability of the drug within the system. |
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DETAILED DESCRIPTION OF THE PRESENTLY PREFERRED EMBODIMENTS The present invention provides improved methods for delivering medicaments and other agents to an individual as well as improved products including such medicaments or agents and methods for producing same.
Pursuant to the present invention, a medicament or agent is contained in a coating that surrounds a tableted gum center formulation.
As used herein "tableted" means that a gum center is provided that has a precise size (within an acceptable range) depending on the medicament or agent and shape.
Thus allows an accurate control of the coating as well as allows one to create products having specific sizes and shapes.
The coating comprises at least 50% by weight of the entire chewing gum product.
As the chewing gum is chewed, the medicament or agent is released into the saliva.
During continual chewing, the medicament or agent in the saliva is then forced through the oral mucosa in the buccal cavity due to the pressure created by the chewing.
The oral mucosa has a thin epithelium and a rich vascularity.
Thus, the oral mucosa favors drug absorption.
In contrast to a typically orally ingested drug, wherein the solution is in contact too briefly for absorption to be appreciable through the oral mucosa, it is believed that during chewing, the agent and/or medicament remains in the buccal cavity and is forced through the oral mucosa.
Also it has been surprisingly found that an increase in the absorption of the drug is achieved as well as an increase in the bioavailability of the drug as compared to typical oral administration.
It has been found that the drug or agent is absorbed much quicker than if it was swallowed as in a typical oral administration.
Indeed, the absorption approaches that of a parenteral administration, and bioavailability is also much greater than oral administration.
Referring to FIG.
1, an embodiment of the chewing gum composition 10 of the present invention is illustrated.
As illustrated, the chewing gum composition 10 includes a tableted gum center 12
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Weight Loss and Supplements 
