Penicillins

DETAILED DESCRIPTION We claim: 1.
A penicillin of formula: ##STR24## wherein R.
sup.
2 is hydrogen or a pharmaceutically acceptable salting ion or in vivo hydrolysable ester radical; and R.
sup.
1 is hydrogen, a pharmaceutically acceptable salting ion, or a pharmaceutically acceptable ester forming radical.
2.
A penicillin as claimed in claim 1, wherein R.
sup.
1 is hydrogen, a pharmaceutically acceptable salting ion or C.
sub.
1-6 alkyl, benzyl, phthalidyl, indanyl, phenyl, or mono-, di-, or tri- (C.
sub.
1-6)-alkyl substituted phenyl.
3.
A penicillin as claimed in claim 2, wherein R.
sup.
1 is hydrogen.
4.
An epimer or epimeric mixture of a pencillin of claim 1.
5.
6,.
alpha.
-Methoxy-6,.
beta.
-[D,L-2-carboxy-2-(4-hydroxyph enyl)acetamido]penicillanic acid or a pharmaceutically acceptable salt thereof.
6.
An epimer or epimeric mixture of a penicillin of claim 5.
7.
6,.
alpha.
-Methoxy-6,.
beta.
-[D,L-2-phenoxycarbonyl-2-(4-hy droxy-phenyl)-acetamido]-penicillanic acid or a pharmaceutically acceptable salt thereof.
8.
An epimer or epimeric mixture of a penicillin of claim 7.
9.
An antibacterial composition comprising an antibacterial amount of a compound of claim 1 and a pharmaceutically acceptable carrier or excipient.
10.
An antibacterial composition comprising an antibacterial amount of a compound of claim 1 and a pharmaceutically acceptable carrier or excipient in oral or parenteral dosage form.
11.
An antibacterial composition comprising an antibacterial amount of a compound of claim 1 and a pharmaceutically acceptable carrier or excipient wherein the antibacterial compound constitutes from 10 to 60% by weight of the composition.
12.
A method of treating a bacterial infection in humans and animals which comprises administering to a human or animal in need thereof an antibacterially effective amount of a composition of claim 9.
13.
A method according to claim 12 wherein the bacterial infection is caused by pseudomonas organisms.




Description:
This invention relates to a class of penicillins which have antibacterial activity and are of value in the treatment of infections in animals, including man and poultry, caused by a wide range of Gram-negative organisms