Pharmaceutical dental formulation for topical application of metronidazole benzoate, chlorhexidine gluconate and local anesthetic

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to the pharmaceutical dental gel formulation for topical application in the form of aqueous gel suitable for the treatment of periodontal diseases.
The present formulation comprises of Metronidazole benzoate, chlorhexidine gluconate (20% solution), the active ingredient is incorporated in the dental gel formulations of the present invention in an amount of about 0.
5 to 3.
0% and 0.
2 to 2 percent by the weight respectively, preferably from about 1% of active metronidazole and 0.
25% active chlorhexidine by weight respectively.
The concentration of local anesthetic, especially lidocaine may fluctuate between 0.
5 to 2 weight % in terms of lidocaine hydrochloride.
The addition of a local anesthetic is not undesired also for medical reasons, for the prevention of dental pain.
Preferred concentration is 0.
5%.
Just like the lidocaine most of the local anesthetics are slightly basic substances forming salts with acids such as hydrochloride.
The local anesthetics are expediently used in the form of their hydrochloride salt.
Local anesthetics of the kind of lidocaine are, in particular, etidocaine, benzocaine.
The concentration of benzocaine as a local anesthetic may fluctuate in the range of 1 to 20%, however preferred concentration is 7.
5%.
As indicated hereinabove, the medium for the active ingredient comprises a mixture of water and propylene glycol.
Propylene glycol concentration fluctuates between 5 to 80%.
Preferred concentration is 5% by weight based on the total weight of the said composition.
Other medium can be used in this specification refers to Glycerin, Polyethylene glycols, but preferred is propylene glycol.
The carboxyvinyl polymer used, as the gelling agent in the present invention is a hydrophilic polymer obtained by the polymerization of acrylic acid as the principal component.
Preferred molecular weight of the polymer is in the range of 4.
times.
10.
sup.
6.
Polymer present in the composition is in the range of 0.
2 to 7% by weight based on the total weight of the said composition