 Method for administering scopolamine transdermally |
| The invention is a method for administering scopolamine base transdermally to inhibit emesis and ... |
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| Process for producing film |
| What I claim is: 1. A process for the preparation of a pharmaceutical composition in the form of a ... |
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| Nitroglycerin-containing polymeric matrix for sustained release on topical application |
| OF THE INVENTION According to the present invention, it has now been found that important ... |
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| Coil shaping apparatus |
| I claim: 1. A shaper for coils for larger electrical machines, which coils comprise loops of ... |
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| Ointment applicator |
| OF THE PREFERRED EMBODIMENT Referring to the drawing, a medication ointment applicator bandage 10 ... |
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| Patch |
| On the other hand, this invention provides a patch having good transdermal property by using a ... |
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| Transdermal drug delivery device |
| We claim: 1. A flexible and compliant medical device for the transdermal administration of a ... |
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| Medicinal plasters |
| What is claimed is: 1. A medicinal plaster comprising a covering layer, a reservoir layer for an ... |
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| Sustained-release transdermal delivery preparations |
| What we claim is: 1. A sustained-release transdermal delivery preparation which comprises a slow-... |
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| Transdermal drug delivery device |
| What is claimed is: 1. A controlled release medical device for delivery of at least one therapeutic ... |
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Polyoxyethylene derivatives as antipruritic ectoparasiticide
| Details |
Inventors: Lover, Myron J.; Singer, Arnold J.; Lynch, Donald M.; Rhodes, III, William E.;
Assignee: Block Drug Co., Inc. (Jersey City, NJ)
Primary Examiner:
Assistant Examiner:
Attorney, Agent or Firm:
Certain ethoxylates have been found to exhibit concurrent activities of particular merit in the treatment of ectoparasitic infestations. |
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DETAILED DESCRIPTION We claim: 1.
A method of controlling ectoparasites or their ova which comprises applying to a human or animal host in need of such control, an effective toxic amount of at least one derivative of polyoxyethylene having an HLB of about 2.
5-13.
5, said derivative being an alkyl ester containing 12 to 24 carbon atoms thereof.
2.
The method of claim 1 wherein said ester moiety contains 12 to 20 carbon atoms.
3.
The method of claim 1 wherein said derivative is employed in combination with an inert pharmaceutically acceptable carrier.
4.
The method of claim 3 wherein said carrier is an aqueous carrier.
5.
The method of claim 1 wherein said derivative is polyoxyethylene (2) oleate, polyoxyethylene (2) laurate of HLB 7.
4 or polyoxyethylene (8) dilaurate.
6.
The method of claim 1 wherein said ectoparasite is lice.
Description:
BACKGROUND OF THE INVENTION Ectoparasites such as lice and mites cause pruritus or pain in their animal or human hosts.
Therapy which simply kills the parasite leaves the host with subcutaneous or intradermal residues which continue to itch for significant time periods after the infestation is extinguished.
Furthermore, scratching during and after the episode frequently leads to painful excoriation.
It has now been found that certain ethoxylates exhibit insecticidal and/or ovicidal activity.
The same boundaries which delimit the insecticidal properties also include compositions which have a valuable degree of topical anesthetic performance.
Although chemically unrelated to any of the conventional anesthetic configurations, these ethoxylates demonstrate topical pharmacologic properties which can be variously characterized as analgesic, anesthetic or antiprurtic.
V.
B.
Wigglesworth (Journal of Experimental Biology, 21, 3, 4 p.
97 (1945)) in a study of transpiration through insect cuticles, reported on the moisture loss of Rhodnius nymphs following treatment with various surfactants.
He observed that the ethoxylates of ring compounds had very little action, and that the eight mole ethoxylate of cetyl alcohol was the most effective surfactant be tested, the nymphs losing 48% of body weight in 24 hours
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