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| Method for chemoprevention of prostate cancer |
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Preparation for reducing cancer symptoms without treating cancer
| Details |
Inventors: Okuda, Hiromichi; Masuno, Hiroshi; Aburada, Masaki; Takeda, Shigefumi; Itoh, Eiko; Matsushita, Moe; Hosoya, Eikichi;
Assignee: Tsumura Juntendo Inc. (Tokyo, JP)
Primary Examiner: Goldberg; Jerome D.
Assistant Examiner: Rollins; John W.
Attorney, Agent or Firm: Ladas & Parry
A composition for reducing cancer symptoms by improving lipid metabolism and eliminating or reducing anorexia in tumor-bearing patients through inhibition of the lipid degradation-promoting action of toxohormone L which comprises an aqueous or aqueous organic solvent extract of one or more crude preparations selected from the group consisting of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix, Hoelen and Glycyrrhizae radix, a method for preparing such a composition, and a method for reducing cancer symptoms using the composition. |
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DETAILED DESCRIPTION We claim: 1.
A composition useful in inhibiting promotion of adipose degradation and anorexia, comprising an effective amount to inhibit promotion of adipose degradation and anorexia of an aqueous extract of a mixed crude preparation consisting of two parts by weight of each of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix and Hoelen, and one part by weight of Glycyrrhizae radix.
2.
A composition according to claim 1, further comprising at least one pharmaceutically acceptable adjuvant or additive.
3.
A method for inhibiting promotion of adipose degradation and anorexia in human cancer patients comprising administering an effective amount to inhibit promotion of adipose degradation and anorexia of a composition containing an aqueous extract of a mixed crude preparation consisting of two parts by weight of each of Astragali radix, Cinnamomi cortex, Rehmanniae radix, Paeoniae radix, Cnidii rhizoma, Atractylodis lanceae rhizoma, Angelicae radix, Ginseng radix and Hoelen and one part by weight of Glycyrrhizae radix to said human patients.
4.
A method according to claim 3, wherein said composition comprises a dry powdered extract and is administered in 2-10 g does three times daily.
Description:
BACKGROUND OF THE INVENTION This invention relates to a drug preparation for reducing cancer symptons without treating cancer.
More particularly, the present invention relates to a drug preparation which improves lipid metabolism and eliminates or reduces anorexia in tumor-bearing patients.
Toxohormone L is an acidic protein with a molecular weight of about 70,000 which is isolated from human ascites hepatoma affecting adipose tissue and is a lipid degradation-promoting factor.
Toxohormone L causes anorexia on injection into the cerebral ventricle of rats and is thought to be a primary factor in adipose decrease in a body suffering from cancerous cachexia (Cancer Res.
41, 284-288 (1981))
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