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Semi-permeable microcapsule with covalently linked layers and method for producing same
| Details |
Inventors: Leblond, Francois; Halle, Jean-Pierre;
Assignee: Leblond; Francois (Quebec, CA) Halle'; Jean-Pierre (Quebec, CA)
Primary Examiner: Saucier; Sandra E.
Assistant Examiner: Singh; Satyendra K.
Attorney, Agent or Firm: Kaufman; Marc S. Villamar; Carlos R. Nixon Peabody, LLP
The present invention relates to semi-permeable microcapsules, which exhibit an increased resistance to mechanical stresses as well as an increased resistance to chemical degradation. More specifically, this semi-permeable microcapsule has a bead enclosing a material such as living cells, covalently linked to a semi-permeable layer, made of a polycation cross-linking derivative, covering the bead. The present invention is also directed to a pharmaceutical composition comprising the above-mentioned semi-permeable microcapsules. The present invention is also directed to the use of such microcapsule in a method for microencapsulating a beaded material and in a method for treating diabetes in a subject. |
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DETAILED DESCRIPTION An object of the present invention is to provide semi-permeable microcapsules, which satisfy the above-mentioned need.
Accordingly, the present invention relates to semi-permeable microcapsules and the method for producing same.
According to a first aspect, the invention is directed to a semi-permeable microcapsule comprising: a bead suited to enclose a material; and a semi-permeable layer covering the bead, said semi-permeable layer being made of a polycation cross-linking derivative covalently linked to the bead.
In another aspect, the invention is directed to a method for microencapsulating a beaded material.
The method comprises the steps of: a) providing a material enclosed within a bead to obtain a beaded material; b) covering the beaded material with a semi-permeable layer made of a polycation cross-linking derivative, to obtain a product; and c) covalently linking the beaded material to the semi-permeable layer.
In a further aspect, the present invention is directed to a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a plurality of the above-mentioned semi-permeable microcapsules, each one of said microcapsules enclosing a material.
In yet another aspect, the present invention is directed to a method for treating diabetes in a subject.
The method comprises the step of administering to said subject, an effective amount of the above-mentioned pharmaceutical composition.
The invention and its advantages will be better understood upon reading the following non-restrictive description of preferred embodiments thereof, made with references to the accompanying drawings.
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