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Stable extract of hypericum perforatum L., a method for producing the same, and corresponding pharmaceutical preparations
| Details |
Inventors: Erdelmeier, Clemens; Grethlein, Eckhart; Lang, Friedrich; Oschmann, Rainer; Stumpf, Karl-Heinz;
Assignee: Dr. Willmar Schwabe GmbH & Co. (Karlsruhe, DE)
Primary Examiner: Witz; Jean C.
Assistant Examiner:
Attorney, Agent or Firm: McDonnell Boehnen Hulbert & Berghoff, Sarussi; Steven J.
Disclosed is an improved extract of Hypericum perforatum L. (St. John's wort) containing Hyperforin, in which the Hyperforin is stabilized against decomposition or degradation by means of a stabilizer. |
|
DETAILED DESCRIPTION What is claimed is: 1.
A stable extract of Hypericum perforatum L.
(St.
John's wort) with a Hyperforin content of 0.
1% to 2%, wherein the extract comprises an amount of a stabilizer selected from the group consisting of organic thiol compounds, ascorbic acid, ascorbic acid derivatives, and mixtures thereof effective to stabilize the Hyperforin against decomposition or degradation.
2.
An extract according to claim 1, wherein the stabilizer is present in a concentration of 0.
01% to 5%, based on the extract.
3.
An extract according to claim 1, wherein the stabilizer is present in a concentration of 0.
2% to 1%, based on the extract.
4.
An extract according to claim 1, wherein the stabilizer is cysteine.
5.
An extract according to claim 1, wherein the stabilizer is glutathione.
6.
An extract according to claim 1, wherein the stabilizer is ascorbic acid.
7.
An extract according to claim 1, wherein the stabilizer is a fatty acid ester of ascorbic acid.
8.
In a process for the preparation of a stable extract containing about 0.
1% to 2% Hyperforin wherein Hypericum perforatum L.
plant material is extracted with pharmaceutical inorganic or organic solvents or mixtures thereof, with the proviso that the solvents are not oily extraction agents, the improvement comprising adding a stabilizer selected from the group consisting of organic thiol compounds, ascorbic acid and derivatives thereof, either during or after the preparation of the extract, in an amount sufficient to stabilize the Hyperforin.
9.
A Process according to claim 8, wherein the plant material is fresh plant material.
10.
A Process according to claim 8, wherein the plant material is dried plant material.
11.
A Process according to claim 8, wherein the stabilizer is cysteine.
12.
A Process according to claim 8, wherein the stabilizer is glutathione.
13.
A Process according to claim 8, wherein the stabilizer is asorbic acid.
14.
A Process according to claim 8, wherein the stabilizer is a fatty acid ester of ascorbic acid
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