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Substance P-Saporin (SP-SAP) conjugates and methods of use thereof
| Details |
Inventors: Lappi, Douglas A.; Wiley, Ronald G.;
Assignee: Advanced Targeting Systems, Inc. (San Diego, CA)
Primary Examiner: Tsang; Cecilia
Assistant Examiner: Borin; Michael
Attorney, Agent or Firm: Phillips; Peter J.
This invention provides a conjugate comprising Substance P, and analogs thereof, and Saporin. This invention provides a method of reducing the perception of pain by a subject comprising administering to the subject an effective dose of the pharmaceutical composition of the conjugate comprising Substance P, and analogs thereof, and Saporin, so as to reduce the perception of pain by the subject. This invention provides a method of selectively destroying NK-1 receptor expressing cells in a subject comprising administering to the subject an effective dose of the conjugate comprising Substance P, and analogs thereof, and Saporin so as to selectively destroy NK-1 receptor expressing cells. Lastly, this invention provides a method for treating a NK-1 receptor associated disorder in a subject, which comprises administering to the subject an amount of the pharmaceutical composition comprising Substance P, and analogs thereof, and Saporin thereby treating the disorder associated with the NK-1 receptor. |
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DETAILED DESCRIPTION OF THE INVENTION This invention provides a conjugate comprising Substance P and Saporin (SP-SAP).
In one embodiment the conjugate comprises an analog of Substance P.
In another embodiment the conjugate comprises an analog of Saporin.
This invention provides a conjugate comprising a Substance P analog having the amino acid sequence CYGGGGGGGRPKPQQFFSarLMet(O.
sub.
2)-amide (SEQ ID No.
1) and Saporin (SSP-SAP).
This invention provides a conjugate comprising a Substance P analog having the amino acid sequence at the N-terminus CYGGGGGGGRPKPQQFFGLM-amide (SEQ ID No.
2) and Saporin (NTE-SAP).
This invention provides a conjugate comprising Substance P and a ribosome-inactivating protein.
This invention provides a conjugate comprising a Substance P analog having the amino acid sequence CYGGGGGGGRPKPQQFFSarLMet(O.
sub.
2)-amide and a ribosome-inactivating protein.
In one embodiment the ribosome-inactivating protein is ricin A chain, gelonin, pokeweed antiviral protein, diphtheria toxin or pseudomonas aeruginosa toxin or fragments thereof.
This invention provides a conjugate comprising a Substance P analog having the amino acid sequence CYGGGGGGGRPKPQQFFGLM-amide and a ribosome-inactivating protein.
In one embodiment the ribosome-inactivating protein is ricin A chain, gelonin, pokeweed antiviral protein, diphtheria toxin or pseudomonas aeruginosa toxin or fragments thereof.
Substance P can be attached to Saporin through a chemical bond, or the composition can be prepared as a chimera using techniques of recombinant DNA.
The conjugate can be used to treat Substance P, or an analog thereof, mediated pathophysiological conditions by specifically targeting cells having Substance P, or an analog thereof, receptors and inhibiting proliferation of or causing death of such cells.
Additionally, the conjugate can be used to target cytotoxic agents into cells having Substance P, or an analog thereof, receptors to inhibit the proliferation of such cells.
Saporin and Saporin derivatives are known to the skilled in the art
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Weight Loss and Supplements 
