Sustained-release transdermal delivery preparations

Details

Inventors: Ueda, Yoshio; Asakura, Sotoo; Murakami, Yoshio; Shimojo, Fumio; Kado, Kazutake;
Assignee: Fujisawa Pharmaceutical Co., Ltd. (Osaka, JP)
Primary Examiner: Page; Thurman K.
Assistant Examiner: Horne; L. R.
Attorney, Agent or Firm: Oblon, Fisher, Spivak, McClelland & Maier

The invention relates to a sustained-release transdermal delivery preparation which comprises a slow-release microcapsule containing 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .beta.-cyclodextrin and a skin-compatible base.

DETAILED DESCRIPTION What we claim is: 1.
A sustained-release transdermal delivery preparation which comprises a slow-release microcapsule containing 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .
beta.
-cyclodextrin and a skin-compatible base.
2.
A sustained-release transdermal delivery preparation of claim 1, which is a dispersion of slow-release microcapsules each composed of 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .
beta.
-cyclodextrin and an encapsulating base in a skin-compatible base.
3.
A sustained-release transdermal delivery preparation of claim 1, which comprises 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .
beta.
-cyclodextrin and a slow-release matrix base.
4.
A sustained-release transdermal delivery preparation of claim 1, which comprises 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .
beta.
-cyclodextrin and an adhesive agent.
5.
A sustained-release transdermal delivery preparation of claim 1, which comprises 2-nitroxymethyl-6-chloropyridine or its occlusion compound with .
beta.
-cyclodextrin and a release control membrane.

Description:
The present invention relates to a sustained-release transdermal delivery preparation containing 2-nitroxymethyl-6-chloropyridine, which is represented by the following chemical formula; ##STR1## or its occlusion compound with .
beta.
-cyclodextrin.
More particularly, the present invention relates to a transdermal delivery preparation rendered long-acting by such means of controlling the rate of release of the active ingredient 2-nitroxymethyl-6-chloropyridine as microencapsulation, interposition of a membrane, dispersion in a polymer matrix and/or dispersion in a suitable gel for the purpose of controlling the blood concentration of said active ingredient at a constant level for an extended time and assuring a sustained efficacy.
2-Nitroxymethyl-6-chloropyridine which is employed in accordance with the invention has vasodilating activity and is of value as a therapeutic agent for vascular disorder

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