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| Method for chemoprevention of prostate cancer |
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| Placental alkaline phosphatase to control diabetes |
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| Process for producing malt alcoholic drink |
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| Delivery of controlled-release system (s) |
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| Composition for the treatment of cutaneous mycosis |
| I claim: 1. An antifungal powder composition for the treatment of cutaneous mycosis that consists ... |
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Topical anti-inflammatory composition and method
| Details |
Inventors: Crandall, Wilson T.;
Assignee:
Primary Examiner: Wityshyn; Michael G.
Assistant Examiner: Lankford; L. Blaine
Attorney, Agent or Firm: Jones & Askew
The present invention comprises compositions and methods that are useful for topically treating inflammation caused by a wide variety of diseases. The compositions comprise an effective amount of a proteolytic enzyme, such as bromelain, in combination with capsaicin in a pharmaceutically acceptable carrier. |
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DETAILED DESCRIPTION The present invention is a composition and method for topically treating inflammation caused by a wide variety of causes including, but not limited to, arthritis, bursitis, sprains, muscle strains, bruises, and hematomas.
The present invention is a composition containing bromelain and capsaicin.
The composition further comprises n-decylmethyl sulfoxide and/or lecithin organogel as agents to increase the transport of bromelain across the skin.
Generally, the composition of the present invention comprises bromelain (PCAA, Kinghurst, Houston, Tex.
) at a concentration of between approximately 0.
5% and 40% by weight, with a preferred concentration of between approximately 10% and 25% by weight, with the most preferred concentration of approximately 15% by weight.
It should be understood that other proteolytic enzymes can be used in the present invention, including but not limited to, collagenase, gelatinase, and elastase.
The anti-inflammatory composition of the present invention also contains capsaicin.
The capsaicin can be either naturally occurring capsaicin oleo resin (PCAA, Kinghurst, Houston, Tex.
) which is commonly extracted from cayenne pepper with an organic solvent such as ether or can be synthetic capsaicin, trans-8-methyl-vanillyl-6-nonenamide (PCAA 10925 Kinghurst, Houston, Tex.
).
The capsaicin is present in the transdermal anti-inflammatory of the present invention at a concentration of between approximately 0.
01% and 0.
1% by weight, with a preferred concentration of between approximately 0.
015% and 0.
09% by weight, with the most preferred concentration of approximately 0.
025% by weight.
The present invention also includes a pharmaceutically acceptable penetrating agent.
A preferred penetrating agent is n-decylmethyl sulfoxide.
n-Decylmethyl sulfoxide has been described as an agent that is useful in facilitating the delivery of small molecules transdermally (see Hoo-Kyun, C.
, et al.
"Transdermal delivery of bioactive peptides: The Effect of n-Decylmethyl Sulfoxide, pH, and Inhibitors on Enkephalin Metabolism and Transport", Pharm
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Weight Loss and Supplements 
