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Topical-composition-for-the-relief-of-pain

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Topical composition for the relief of pain

Details

Inventors: Botknecht, Jonah; Fishman, Robert;
Assignee: Medical Research Industries,Inc. (Davie, FL)
Primary Examiner: Page; Thurman K.
Assistant Examiner: Seidleck; Brian K.
Attorney, Agent or Firm: Schwartz; Robert M., Kauder; Otto S.

Disclosed is a topical composition for relieving pain in a person in need of such relief, consisting essentially of an effective amount of a combination of at least one corticoid analgesic, at least one arylpropionic acid type analgesic, and at least one p-aminobenzoic acid ester type local anesthetic; an amount effective in enhancing the effectiveness in relieving pain of the combination of capsaicin, and an amount effective to increase the transmission thereof of through the skin of at least one phospholipid and at least one polyoxyethylenepolyoxypropylene copolymer.

DETAILED DESCRIPTION What is claimed is: 1.
A topical composition for relieving pain in a person in need of such relief, consisting essentially of an effective amount of a combination of hydrocortisone, ibuprofen, and at least one of lidocaine and benzocaine; an amount of capsaicin effective in enhancing the effectiveness in relieving pain of said combination, and an amount effective to increase the transmission of said combination through the skin of at least one phospholipid and at least one polyoxyethylenepolyoxypropylene copolymer.
2.
A topical composition according to claim 1 in which the phospholipid is lecithin.
3.
A topical composition according to claim 1 in which the concentration of phospholipid is in the range of 5 to 50 milliliters per 100 milliliters of composition.
4.
A topical composition according to claim 1 in which the concentration of polyoxyethylenepolyoxypropylene copolymer is in the range of 2 to 15 milliliters per 100 milliliters of composition.
5.
A topical composition according to claim 1 in which the relative proportions of phospholipid and polyoxyethylenepolyoxypropylene copolymer are in the range of 25:1 to 1:3.
6.
A topical composition according to claim 1 with at least one topically acceptable carrier added, selected from the group consisting of fatty acid alkyl esters having thirteen to thirty-six carbon atoms, ethanol, and water.
7.
A topical composition according to claim 1 which is a cream.
8.
The method of relieving pain of a person in need of such relief, comprising topically administering to said person a topical composition according to claim 1 for a period of time sufficient to achieve relief of pain.
9.
The method of claim 8 in which the quantity of composition administered daily is in the range of 0.
1 to 10 milliliters.
10.
A topical composition according to claim 1 in which the local anesthetic is lidocaine.
11.
A topical composition according to claim 1 in which the local anesthetic is benzocaine.
12.
A topical composition according to claim 1 in which the level of hydrocortisone is in the range from 0

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