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Topical delivery systems for active agents
| Details |
Inventors: Niemiec, Susan M.; Wang, Jonas C. T.; Wisniewski, Stephen J.; Stenn, Kurt S.; Lu, Gwang Wei;
Assignee: Johnson & Johnson Consumer Companies, Inc. (Skillman, NJ)
Primary Examiner: Criares; Theodore J.
Assistant Examiner: Kim; Jennifer
Attorney, Agent or Firm:
This invention relates to a method for enhancing the transmembrane penetration of benefit agents using a certain non-ionic lipid/surfactant-containing formulation as an enhancing agent, and the compositions used therein. Various active agents, such as anti-dandruff agents, hair growth agents, hair inhibitor agents, anti-acne agents, anti-aging agents, depilatory agents, and depigmentation agents, may be effectively delivered into the skin, hair follicles and sebaceous glands using the compositions of the present invention. |
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DETAILED DESCRIPTION In accordance with the present invention, we have found a composition for enhancing the topical delivery of benefit agents comprising, consisting essentially of, or consisting of, based upon the total weight of the composition,: A.
from about 1 percent to about 10 percent of a nonionic lipid selected from i.
glyceryl monoesters having a fatty acid chain containing from about 3 to about 50 carbon atoms; ii.
glyceryl diesters having a fatty acid chain containing from about 5 carbon atoms to about 25 carbon atoms; iii.
alkoxylated alcohols alkoxylated with ethylene oxide or propylene oxide; iv.
alkoxylated alkyl phenols alkoxylated with ethylene oxide or propylene oxide; v.
alkoxylated acids alkoxylated with ethylene oxide or propylene oxide; vi.
alkoxylated amides alkoxylated with ethylene oxide or propylene oxide; vii.
alkoxylated sugar derivatives alkoxylated with ethylene oxide or propylene oxide; viii.
alkoxylated derivatives of natural oils or waxes alkoxylated with ethylene oxide or propylene oxide; ix.
polyoxyethylene polyoxypropylene block copolymers alkoxylated with ethylene oxide or propylene oxide; x.
polyoxyethylene fatty ethers having a fatty acid chain containing from about 10 carbon atoms to about 18 carbon atoms; xi.
steroids; xii.
fatty acid esters of alcohols where the fatty acid is straight or branched chain having from about 10 carbon atoms to about 20 carbon atoms and the alcohol is straight or branched chain having 1 to 10 carbon atoms; or xiii.
mixtures thereof; B.
from about 75 percent to about 98 percent of a vehicle solution comprised of: 1) a first vehicle component comprised of water or a mixture of water and a hydrophilic compound; and 2) a second vehicle component comprised of an alcohol, a polyol, or mixtures thereof; and C.
an effective amount of the benefit agent(s).
In another embodiment of the present invention, we have found a topical delivery system for active agents comprising, consisting of, or consisting essentially of, based upon the total weight of the delivery system, A
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