 Sparkle linen spray |
| What is claimed is: 1. A liquid composition for providing a sparkling appearance to a surface ... |
|
|
Transdermal drug delivery device
| Details |
Inventors: Campbell, Patricia S.; Eckenhoff, James B.; Place, Virgil A.;
Assignee: ALZA Corporation (Palo Alto, CA)
Primary Examiner: Griffin; Ronald W.
Assistant Examiner:
Attorney, Agent or Firm: Stone; Steve, Mandell; Edward, Precivale; Shelley
A medical device for the transdermal delivery of an active agent through sensitive intact skin is provided. The device comprises a matrix containing the drug having reinforcing means, preferably in the form of a fabric, embedded in the upper surface of the matrix. The matrix is formed of an agent permeable material which is tacky but does not adhesively bond to the skin. The device is sufficiently flexible and deformable that the combination of tackiness, flexibility, and deformation permits the device to be maintained in agent transmitting relationship upon skin at such sensitive areas as the scrotum, labia, breast, or penis, for example. In certain embodiments, the skin distal surface is provided with a layer of an agent impermeable material to reduce transfer of the agent from the patient to others. |
|
DETAILED DESCRIPTION We claim: 1.
A flexible and compliant medical device for the transdermal administration of a biological agent through intact skin at sensitive body locations comprising, in combination: (a) an agent reservoir comprising said agent dispersed through a non-aqueous, nonadhesive polymeric carrier permeable to said agent, said reservoir having a body contacting surface through which said agent is released to the skin and a body distal surface opposite said body contacting surface, the body contacting surface of said reservoir having a tack in the range of about 50-500 g/cm.
sup.
2 at 35.
degree.
C.
; (b) a flexible bonding agent substantially less permeable to said agent than the polymeric carrier forming said reservoir, said bonding agent coating substantially all of said body distal surface of said reservoir; and (c) fibrous reinforcing means imbedded in said bonding means to a depth that does not penetrate through said body contacting surface and does not submerge said reinforcing means in said bonding means, said imbedded fibrous reinforcing means forming the body distal surface of said device; whereby said bonding agent bonds said fibrous reinforcing means to said reservoir, substantially impedes the transfer of said agent from the body distal surface of said device to other surfaces and the body distal surface of said device retains a fibrous texture.
2.
The device of claim 1 wherein said agent is selected from the group consisting of testosterone, progesterone, estradiol, acyclovir, interferon, cortisone and phenolphthalein, cyproterone, LHRH, their active metabolites, and their prodrugs.
3.
A method of transdermal administration of an agent which comprises applying a device according to claim 1 to a body site selected from the group consisting of the scrotum, the labia, the penis or the breast, and maintaining said system in place for an extended period of time.
4.
The device of claim 1 further comprising a removable agent impermeable liner disposed on the body contacting surface to protect the device in storage
|
| Related patents |
|
|
Medicinal plasters
What is claimed is: 1. A medicinal plaster comprising a covering layer, a reservoir layer for an active compound and a detachable protective layer which is substantially ...
|
|
|
Sustained-release transdermal delivery preparations
What we claim is: 1. A sustained-release transdermal delivery preparation which comprises a slow-release microcapsule containing 2-nitroxymethyl-6-chloropyridine or its ...
|
|
|
Transdermal drug delivery device
What is claimed is: 1. A controlled release medical device for delivery of at least one therapeutic agent in a pre-determined delivery rate pattern to a biological ...
|
|
|
Production of beer
What I claim is: 1. A process for improving the filterability of wort or beer comprising treating said wort or beer with xylanase produced by Disporotrichum ...
|
|
|
Slotted splash bars for gas liquid contact apparatus
AND OBJECTS According to the present invention, a splash bar is provided for a cooling tower which includes an elongate, generally flat splash plate section and at least ...
|
|
|
Anti-protozoal treatment
I claim: 1. A method for treating giardial infection of a mammal in need of treatment comprising the administration to said mammal of an effective, non-toxic ...
|
|
|
Method of producing finely divided polymer particles
OF THE INVENTION In the aforementioned suspension polymerization method of the prior art, the viscosity of monomer droplets noticeably increases during the polymerizing ...
|
|
|
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles 1,2-benzisothiazoles
The present invention relates to microencapsulated 1,2-benzazoles and their use in the treatment of warm blooded animals suffering from mental disease. In a preferred ...
|
|
|
Microencapsulated 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
The present invention relates to microencapsulated 1,2-benzazoles and their use in the treatment of warm blooded animals suffering from mental disease. In a preferred ...
|
|
|
Preparation of microparticles having a selected release profile
OF THE PREFERRED EMBODIMENTS Overview The present invention relates to microparticles having a selected release profile for release of the active agent from the ...
|
|
|
Weight Loss and Supplements 
