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___... |
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Use of amidoamines to treat or prevent acanthamoeba and fungal infections
| Details |
Inventors: Schlitzer, Ronald L.; Dassanayake, Nissanke L.; Rosenthal, Ruth Ann; Buck, Sally L.;
Assignee: Alcon, Inc. (Hunenberg, CH)
Primary Examiner: Carr; Deborah D.
Assistant Examiner:
Attorney, Agent or Firm: Brown; Gregg C.
The use of amidoamines to treat or prevent infections attributable to Acanthamoeba and fungi is described. The amidoamines are highly effective against both Acanthamoeba and fungi, and are less toxic to delicate tissues that may become infected with these types of microorganisms (e.g., the cornea). |
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DETAILED DESCRIPTION What is claimed is: 1.
A method of treating infections attributable to Acanthamoeba, fungi or a combination of Acanthamoeba and fungi, which comprises applying a topical pharmaceutical composition to the affected tissues, said composition comprising an antimicrobial effective amount of a compound of the following formula: R1—(OCH2CH2)m—X—(CH2)n—Y (I) wherein: ##STR11## Y is —N(R3)2 or ##STR12## Z is oxygen or NR4; R1 is C6-C18 saturated or unsaturated alkyl, alkylaryl, or alkoxyaryl; m is zero to 16; n is 2 to 16; R2, R3, and R4 are independently hydrogen, C1-C8 saturated or unsaturated alkyl or hydroxyalkyl, or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable vehicle therefor.
2.
A method according to claim 1, wherein n is 2 to 4, and m is 0 to 5.
3.
A method according to claim 2, wherein R2 is hydrogen or methyl, and R3 is methyl or ethyl.
4.
A method according to claim 1, wherein R1 is heptadec-8-enyl, undecyl, undecenyl, dodecyl, tridecyl, tetradecyl, pentadecyl or heptadecyl, R2 is hydrogen or methyl, R3 is methyl or ethyl, and R4 is hydrogen, methyl or hydroxyethyl.
5.
A method according to claim 1, wherein R1 is tridecyl, m is 0, n is 3, Y is N(R3)2 and R3 is methyl.
6.
A method according to claim 1, wherein the composition further comprises an antimicrobial effective amount of a cationic antiseptic.
7.
A method according to claim 6, wherein the cationic antiseptic is selected from the group consisting of chlorhexidine, PHMB and polyquaternium-1.
8.
A method according to claim 1, wherein the composition is applied to ophthalmic tissues.
9.
A method according to claim 1, wherein the composition is applied to ophthalmic tissues to treat an Acanthamoeba infection.
10.
A method according to claim 5, wherein the composition is applied to ophthalmic tissues.
11.
A method according to claim 5, wherein the composition is applied to ophthalmic tissues to treat an Acanthamoeba infection.
Description:
BACKGROUND OF THE INVENTION The present invention is directed to the use of certain amidoamines to treat or prevent infections attributable to Acanthamoeba, fungi or combinations of these two types of microorganisms
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