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Use of male essence to alter female endocrine response
| Details |
Inventors: Cutler, Winnifred B.; Preti, George; Garcia, Celso R.;
Assignee: Trustees of the University of Penn. (Philadelphia, PA)
Primary Examiner: Moezie; F. T.
Assistant Examiner:
Attorney, Agent or Firm:
A novel method for treating a human female is disclosed comprising the step of exposing the nasal region of said female to at least a portion of the axillary secretions of a human male. This exposure is preferably continued in amounts and for a duration which are effective to significantly alter an endocrine related characteristic, such as the menstrual cycle length, of that female. In particular, the portions of male axillary secretions to be exposed to the female preferably comprise one or more compounds such as androstenol, dehydroepiandrosterone, and/or a compound or compounds exhibiting a burnt heavy axiallary-like odor which elutes at about 50 minutes as shown on the FID response curve of FIG. 3B. Studies show that pooled male donor secretions are effective to alter aberrant menstrual cycles, particularly those exhibiting luteal phase defects such that they become presumptively fertile menstrual cycles having durations of about 29.5.+-.3 days. Symptoms of perimenopause, such as hot flashes, night sweats and irregular menstrual cycles, are also treatable using the methods of this invention, which tend to promote female endocrine regularity and longevity. |
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DETAILED DESCRIPTION The present invention provides a novel method for altering and/or regularizing human female endocrine-related characteristics, such as the length of the menstrual cycle.
For example, applicants have discovered that the axillary secretions of males, when exposed to the nasal region of females with a history of aberrant cycle lengths (<26 or> 33 days) tend to induce normal, presumptively fertile menstrual cycles having lengths of about 29.
5.
+-.
3 days.
Applicants have demonstrated that, as compared to controls receiving only solvent (ethanol) applications, woman receiving male axillary extracts experienced more regular cycles, and, based on BBT data, more presumptively fertile cycles.
In accordance with the preferred embodiment of the present invention, the male donor axillary secretions should be exposed to the nasal region of the female for a duration and in amounts effective to significantly alter and/or regularize the expected cycle length of that female.
Such exposure should preferably be accomplished through periodic applications of male donor extract of the axillary secretions of one or more males.
The method is particularly useful in treating woman exhibiting aberrant menstrual cycles which are either monophasic, or which have lengths 26 days or less or 33 days or more.
Menstrual cycles of 26 days or less are often indicative of luteal phase defects which are associated with presumptively infertile cycles.
Accordingly, the present method is particularly adapted for increasing the presumptive fertility of those cycles by exposing a female having a menstrual cycle exhibiting a luteal phase of less than 12 days to the subject male donor axillary secretions for a period of time sufficient to increase the length of the luteal phase of the that menstrual cycle to at least 12, and preferably to about 14-16 days.
In accordance with a further embodiment of the present invention, male axillary secretions or extracts are exposed to the nasal region of perimenopausal women to treat endocrine-related characteristics such as the symptoms of menopause
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